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5355-48-6

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  • Card-20(22)-enolide, 3-[(O-4-O-acetyl-2,6-dideoxy-beta-d-ribo-hexopyranosyl-(1→4)-O-2,6-dideoxy-beta-d-ribo-hexopyranosyl-(1→4)-2,6-dideoxy-beta-d-ribo-hexopyranosyl)oxy]-12,14-dihydroxy-, (3beta,5b

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  • Card-20(22)-enolide,3-[(O-4-O-acetyl-2,6-dideoxy-b-D-ribo-hexopyranosyl-(1®4)-O-2,6-dideoxy-b-D-ribo-hexopyranosyl-(1®4)-2,6-dideoxy-b-D-ribo-hexopyranosyl)oxy]-12,14-dihydroxy-, (3b,5b,12b)-

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5355-48-6 Usage

Chemical Properties

White Solid

Originator

Novodigal ,Asta Medica Arzneimittel

Uses

Digoxin derivative, a cardiotonic glycosides

Manufacturing Process

Dried crude product of the partial acetylation of digoxin (42 g) prepared from digitalis - is dissolved under reflux in acetone (480 ml) and n-hexane (2400 ml) is added to the solution with stirring. Fine crystals, which begin to separate immediately, are left at room temperature for 5 hours, then they are filtered with suction, washed with n-hexane and dried in vacuum at 40°C, yielding 32 g of crude β-acetyldigoxin (product 1). Product 1 (31 g) is dissolved under reflux in chloroform (500 ml) and toluene (2500 ml) is added thereto with stirring. The crystals, which separate after standing for 6 hours at room temperature, are filtered, washed with toluene and ether and dried in vacuum yielding 29 g of β-acetyldigoxin (product 2). MP: 249°-251°C. The filtrate, which results from the separation of product 1, is evaparated to dryness in vacuum. The residue, which mainly contains unreacted digoxin, is purified by recrystallization from pyridine/ether/water (3.5:5:40) and repeatedly acetylated. It can then be recycled to produce more β- acetyldigoxin. The filtrate resulting from the separation of product 2 is evaporated to dryness. The resulting residue contains the di- and polyacetyl derivatives of digoxin, which are deacetylated to digoxin in a known manner and later is returned to a further acetylation process and can then be recycled to produce more β-acetyldigoxin. Beta-Acetyldigoxin may be prepared from digoxin, acetic acid and dicyclohexylcarbodiimide using the last one as a condensing agent.

Therapeutic Function

Cardiotonic

Check Digit Verification of cas no

The CAS Registry Mumber 5355-48-6 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 5,3,5 and 5 respectively; the second part has 2 digits, 4 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 5355-48:
(6*5)+(5*3)+(4*5)+(3*5)+(2*4)+(1*8)=96
96 % 10 = 6
So 5355-48-6 is a valid CAS Registry Number.

5355-48-6 Well-known Company Product Price

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  • Sigma-Aldrich

  • (Y0000565)  β-Acetyldigoxin  European Pharmacopoeia (EP) Reference Standard

  • 5355-48-6

  • Y0000565

  • 1,880.19CNY

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  • Sigma-Aldrich

  • (Y0000642)  β-Acetyldigoxin for peak identification  European Pharmacopoeia (EP) Reference Standard

  • 5355-48-6

  • Y0000642

  • 1,880.19CNY

  • Detail

5355-48-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name β-ACETYLDIGOXIN

1.2 Other means of identification

Product number -
Other names Cardioreg

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:5355-48-6 SDS

5355-48-6Relevant articles and documents

Catalyst recognition of cis-1,2-diols enables site-selective functionalization of complex molecules

Sun, Xixi,Lee, Hyelee,Lee, Sunggi,Tan, Kian L.

, p. 790 - 795 (2013/09/23)

Carbohydrates and natural products serve essential roles in nature, and also provide core scaffolds for pharmaceutical agents and vaccines. However, the inherent complexity of these molecules imposes significant synthetic hurdles for their selective functionalization and derivatization. Nature has, in part, addressed these issues by employing enzymes that are able to orient and activate substrates within a chiral pocket, which increases dramatically both the rate and selectivity of organic transformations. In this article we show that similar proximity effects can be utilized in the context of synthetic catalysts to achieve general and predictable site-selective functionalization of complex molecules. Unlike enzymes, our catalysts apply a single reversible covalent bond to recognize and bind to specific functional group displays within substrates. By combining this unique binding selectivity and asymmetric catalysis, we are able to modify the less reactive axial positions within monosaccharides and natural products.

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