5349-17-7 Usage
Description
4-(Bromoacetyl)pyridine hydrobromide is an organic compound that serves as an important intermediate in the synthesis of various chemical and pharmaceutical products. It is characterized by its bromine atom attached to an acetyl group, which is in turn connected to a pyridine ring. This unique structure allows it to participate in a range of chemical reactions, making it a versatile building block in the field of organic chemistry.
Uses
Used in Pharmaceutical Industry:
4-(Bromoacetyl)pyridine hydrobromide is used as a synthetic intermediate for the development of novel drugs. Its ability to form covalent bonds with target proteins makes it a valuable component in the design and synthesis of potent, selective, and orally bioavailable inhibitors.
Used in the Design and Synthesis of Imidazole Inhibitors:
In the context of p38 mitogen-activated protein kinase (p38 MAPK) inhibitors, 4-(Bromoacetyl)pyridine hydrobromide plays a crucial role in the preparation of 2-Phenyl-4-(4-pyridyl)imidazole. 4-(Bromoacetyl)pyridine hydrobromide has been identified as a potent and selective inhibitor of p38 MAPK, which is a key enzyme involved in various cellular processes, including inflammation and cell growth. By targeting this enzyme, 2-Phenyl-4-(4-pyridyl)imidazole has the potential to be a therapeutic agent for treating conditions such as rheumatoid arthritis, inflammatory bowel disease, and certain types of cancer.
Check Digit Verification of cas no
The CAS Registry Mumber 5349-17-7 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 5,3,4 and 9 respectively; the second part has 2 digits, 1 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 5349-17:
(6*5)+(5*3)+(4*4)+(3*9)+(2*1)+(1*7)=97
97 % 10 = 7
So 5349-17-7 is a valid CAS Registry Number.
InChI:InChI=1/C7H6BrNO.BrH/c8-5-7(10)6-1-3-9-4-2-6;/h1-4H,5H2;1H
5349-17-7Relevant articles and documents
SUBSTITUTED PYRAZOLO[4,3-b]PYRIDINES AND THEIR USE AS GLUN2B RECEPTOR MODULATORS
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Paragraph 0263; 0264; 0265; 0266, (2020/12/25)
Substituted pyrazolo[4,3-b]pyridines as GluN2B receptor ligands. Such compounds may be used in GluN2B receptor modulation and in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by GluN2B receptor activity.
HETEROARYL SUBSTITUTED BETA-HYDROXYETHYLAMINES FOR USE IN TREATING HYPERGLYCAEMIA
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Page/Page column 54-55, (2019/04/11)
There is herein provided a compound of formula (I) or a pharmaceutically acceptable salt thereof,wherein the ring containing Q1to Q5, and the groups R1, R2 and R3, have meanings as provided in the description.
Preparation method of 4-(bromoacetyl) pyridine hydrobromide
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Paragraph 0026; 0027; 0028; 0029, (2017/08/28)
The invention relates to the technical field of synthesis of medical intermediates, in particular to a preparation method of 4-(bromoacetyl) pyridine hydrobromide of a ceftaroline fosamil intermediate. The method comprises the following steps that 4-acetyl pyridine is used as a raw material, ester is used as a solvent and NBS serves as a bromination reagent to obtain the 4-(bromoacetyl) pyridine hydrobromide through reaction. The preparation method is mild in reaction condition, high in yield, high in safety, green, environmentally friendly, low in cost and suitable for industrial production.