53417-18-8

Basic information

• Product Name: 1H-Isoindole-1,3(2H)-dione, 5,5'-carbonylbis[2-(4-hydroxyphenyl)-
• CAS NO: 53417-18-8
• Molecular Formula: C29H16N2O7
• Molecular Weight: 504.455
• Mol File: 53417-18-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1H-Isoindole-1,3(2H)-dione, 5,5'-carbonylbis[2-(4-hydroxyphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Isoindole-1,3(2H)-dione, 5,5'-carbonylbis[2-(4-hydroxyphenyl)-(53417-18-8)
• EPA Substance Registry System: 1H-Isoindole-1,3(2H)-dione, 5,5'-carbonylbis[2-(4-hydroxyphenyl)-(53417-18-8)

Safety Data

• Hazardous Substances Data: 53417-18-8(Hazardous Substances Data)

Upstream product

• 123-30-8 4-amino-phenol 
• 2421-28-5 dianhydride of benzophenone-3,4,3',4'-tetracarboxy acid 

Relevant articles and documents

Evaluation of biological properties of 3,3′,4,4′-benzophenonetetracarboxylic dianhydride derivatives and their ability to inhibit hexokinase activity

This investigation has explored the properties of 3,3′,4,4′-benzophenonetetracarboxylic dianhydride (BDTA) derivatives with regard to their being prospective inhibitors of hexokinase II (HKII). A pluripotent embryonic carcinoma cell line P19 (ECC), was used as the biological target for newly generated potential inhibitors of HKII. The results obtained from Virtual High-Throughput Screening (VHTS), molecular modeling and biological activity studies showed BDTA to be a promising leading structure with a good binding score and simplest functionalization. The inhibitory effect was measured after 72?h incubation. Of selected BDTA derivatives, the most active was compound 3b, containing 3-hydroxyphenyl moiety in the para position, being able at 100?μM to decrease the mass of differentiated P19dCs cells by 30%, changing both the mitochondrial transmembrane potential and reactive oxygen species level. Under these conditions, only compound 3b had the ability to decrease hexokinase activity in a dose-dependent manner.

New copoly(ether-imide-sulfone) oligomers having pendant ionic groups

New copoly(ether-imide-sulfone) oligomers have been synthesized by solution polycondensation reaction of bis(pchlorophenyl)sulfone with various imide bisphenols and 2,2-bis(4-hydroxyphenyl)-propane (Bisphenol A). The Williamson polyetherification procedur