5329-12-4

Basic information

• Product Name: 2,4,6-Trichlorophenylhydrazine
• Synonyms: 2,4,6-Trichlorohydrazinobenzene;Hydrazine, (2,4,6-trichlorophenyl)-;Hydrazine,(2,4,6-trichlorophenyl)-;2,4,6-TRICHLOROPHENYLHYDRAZINE;2,4,6-TRICHLORPHENYLHYDRAZINE;AKOS BBS-00004217;2,4,6-Trichlorophenylhydrazine,98%;2,4,6-Trichloropheny
• CAS NO: 5329-12-4
• Molecular Formula: C₆H₅Cl₃N₂
• Molecular Weight: 211.48
• EINECS: 226-217-2
• Product Categories: FINE Chemical & INTERMEDIATES;Aromatic Hydrazides, Hydrazines, Hydrazones and Oximes;Phenylhydrazine
• Mol File: 5329-12-4.mol
• Article Data: 4

Chemical Properties

• Melting Point: 140-142 °C(lit.)
• Boiling Point: 343.65°C (rough estimate)
• Flash Point: 119.2 °C
• Appearance: /
• Density: 1.6776 (rough estimate)
• Vapor Pressure: 0.00574mmHg at 25°C
• Refractive Index: 1.6000 (estimate)
• Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
• Solubility: benzene: 0.1 g/mL, clear
• PKA: 3.80±0.33(Predicted)
• Water Solubility: Soluble in acetone. Insoluble in water.
• BRN: 1841962
• CAS DataBase Reference: 2,4,6-Trichlorophenylhydrazine(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4,6-Trichlorophenylhydrazine(5329-12-4)
• EPA Substance Registry System: 2,4,6-Trichlorophenylhydrazine(5329-12-4)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 36/37/38-20/21/22
• Safety Statements: 26-36-36/37
• RIDADR: UN2811
• WGK Germany: 3
• TSCA: Yes
• HazardClass: 6.1
• PackingGroup: III
• Hazardous Substances Data: 5329-12-4(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2,4,6-Trichlorophenylhydrazine is used as a pharmaceutical intermediate for the synthesis of various drugs. Its chemical properties make it a valuable building block in the development of new pharmaceutical compounds, contributing to the creation of medications with specific therapeutic effects.
As a chemical intermediate, 2,4,6-Trichlorophenylhydrazine plays a crucial role in the production of different pharmaceuticals, enhancing the range of available treatments and contributing to advancements in the healthcare sector.

InChI:InChI=1/C6H5Cl3N2.H2O4S/c7-3-1-4(8)6(11-10)5(9)2-3;1-5(2,3)4/h1-2,11H,10H2;(H2,1,2,3,4)

Upstream product

• 34684-21-4 2-chlorosulfonylbenzoyl chloride 
• 6461-76-3 1,2-benzenedisulfonyl dichloride 
• 13097-10-4 3-anilino-2-thioxo-1,3-thiazolidin-4-one 
• 3019-33-8 3-anilino-imidazolidine-2,4-dione 
• 64-17-5 ethanol 
• 588-64-7 benzaldehyde phenylhydrazone 
• 6958-44-7 benzaldehyde N-(2,4,6-trichlorophenyl)hydrazone 
• 25939-05-3 N-(2,4,6-trichloro)phenylbenzhydrazidoyl chloride 
• 18708-70-8 2,4,6-trichloronitrobenzene 
• 67-56-1 methanol 
• 104891-98-7 3-Amino-3-(2,4,6-trichlor-phenylazo)propensaeuremethylester 
• 872265-83-3 N-chloro-N'-(2,4,6-trichloro-phenyl)-urea 
• 141-52-6 sodium ethanolate 

Downstream Products

• 6958-44-7 benzaldehyde N-(2,4,6-trichlorophenyl)hydrazone 
• 202274-75-7 4-nitro-benzoic acid-[N'-(2,4,6-trichloro-phenyl)-hydrazide] 
• 712303-93-0 4-methoxy-benzoic acid N'-(2,4,6-trichloro-phenyl)-hydrazide 
• 35693-92-6 2,4,6-trichlorobiphenyl 
• 156636-81-6 1-Phenylpropanone (2,4,6-trichlorophenyl)hydrazone 
• 143643-87-2 butan-2-one (2,4,6-trichlorophenyl)hydrazone 

Relevant articles and documents

Process for producing chlorophenylhydrazine compounds

A process for producing a chlorohenylhydrazine compound is disclosed, which comprises chlorinating at least one hydrogen atom on the phenyl nucleus in a beta-imidated phenylhydrazine compound and subsequently hydrolyzing the chlorinated compound. Said chlorophenylhydrazine compound is useful as starting material for the production of herbicide, insecticide and photographic coupler is produced in high yield and low cost.

Preparation of 2,4,6-trichlorophenylhydrazine

Disclosed is a process for the preparation of 2,4,6-trichlorophenylhydrazine by chlorinating the reaction product of phenylhydrazine and a dicarboxylic anhydride to obtain an N-(2,4,6-trichloroanilino)dicarboximide which is reacted with a base capable of liberating 2,4,6-trichlorophenylhydrazine therefrom.

New Azoolefines and their Acidic Cleavage to Aryldiimines

3-Amino-1-aryl-3',3'-dimethyl-pyrazolin-4-spiro-2'-oxiran-5-ones (3a-c) undergo ring opening with methoxide forming methyl 3-amino-3-arylazo-propenoates (5a-c). 5a-c are cleaved under acidic conditions.The main products of the cleavage of 5c with methanolic hydrochloric acid are nitrogen, 2,4,6-trichloro-benzene (6), 2,4,6-trichloro-aniline (9) and 2,4,6-trichloro-phenylhydrazine (10).Intermediates of the cleavage of 5 are aryldiimines trapped with benzaldehyde as the corresponding benzhydrazides (12a,b).