53170-19-7Relevant articles and documents
Deuterated substituted butenamide and preparation method and application thereof
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Paragraph 0181-0183, (2021/10/13)
The invention belongs to the field of medicines, and particularly relates to deuterated substituted butenamide and a preparation method and application thereof. The deuterated substituted butenamide is prepared from the intermediate compound shown V. Compared with the prior art, the deuterated substituted butenamide is used. The deuterated substituted butane acetamide - N - oxide has a good anti-cancer effect, and the application prospect of the medicine is increased for anti-cancer treatment drugs. , The deuterated substituted butanamide and the deuterated substituted butane acetamide - N - oxide are prepared by the process, the operation is simple, the purity is high, the three wastes are few, and the process is environment-friendly and friendly.
A practical synthesis of deuterated methylamine and dimethylamine
Liu, Zhaogang,Ren, Xiangyu,Wang, Peng
, p. 265 - 268 (2020/11/30)
In recent years, several deuterated drugs have entered clinical trials and have been approved for use. Deuterated methylamine and dimethylamine as important intermediates play significant roles in the preparation of deuterated drugs. In this study, we have developed a new method to prepare deuterated methylamine and dimethylamine. This method employs Boc-benzylamine as the starting material and TsOCD3 as the deuterated methylation reagent. Our method gives relatively high yields and involves simple purifications, which provide a favourable supplement for the development and synthesis of deuterated drugs in the future.
Method for synthesizing deuterated dimethylamine salt with deuterated methanol
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Paragraph 0025-0026; 0031-0032, (2020/07/12)
The invention discloses a method for synthesizing a deuterated dimethylamine salt by using deuterated methanol. The method comprises the following steps: (1) carrying out a reaction on a compound 1 with a sulfonyl chloride compound to obtain a compound 2; (2) carrying out a reaction on the compound 2 with R2-NH2 to obtain a compound 3; and (3) carrying out a reaction on the compound 3 with an acidto obtain the deuterated dimethylamine salt. The preparation method provided by the invention is simple and efficient, and has a good industrial application prospect.