53054-07-2

Basic information

• Product Name: NOHA
• Synonyms: N-OMEGA-HYDROXYL-L-ARGININE, DIHYDROCHLORIDE;NOHA;NG-HYDROXY-L-ARGININE;NW-HYDROXYL-L-ARGININE, DIHYDROCHLORIDE;NOMEGA-Hydroxy-L-arginine;5-[[Amino(hydroxyamino)methylene]amino]-L-norvaline;5-[[Imino(hydroxyamino)methyl]amino]-L-norvaline;Nω-Hydroxy-L-arginine
• CAS NO: 53054-07-2
• Molecular Formula: C₆H₁₄N₄O₃
• Molecular Weight: 263.12
• Mol File: 53054-07-2.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 441.4°Cat760mmHg
• Flash Point: 220.8°C
• Appearance: /
• Density: 1.53g/cm³
• Vapor Pressure: 1.2E-09mmHg at 25°C
• Refractive Index: 1.604
• PKA: 2.49±0.24(Predicted)
• CAS DataBase Reference: NOHA(CAS DataBase Reference)
• NIST Chemistry Reference: NOHA(53054-07-2)
• EPA Substance Registry System: NOHA(53054-07-2)

Safety Data

• Hazardous Substances Data: 53054-07-2(Hazardous Substances Data)

Usage

Description

N-hydroxy-L-arginine (NOHA) is an organic chemical compound that plays a crucial role in the biosynthesis of nitric oxide, a vital cellular signaling molecule in the human body. It is generated by the enzyme nitric oxide synthase (NOS) from the amino acid L-arginine. NOHA functions as a potent inhibitor of Arginase, an enzyme responsible for breaking down L-arginine, thus enhancing the bioavailability of L-arginine for nitric oxide synthesis. However, it is noteworthy that NOHA can also inhibit nitric oxide production under certain conditions.

Uses

Used in Pharmaceutical Industry:
NOHA is used as a therapeutic agent for the regulation of nitric oxide levels in the body. Its ability to inhibit Arginase helps maintain the availability of L-arginine, which is essential for the synthesis of nitric oxide. This makes NOHA a potential candidate for the treatment of conditions where nitric oxide levels are critical, such as cardiovascular diseases and immune responses.
Used in Research Applications:
NOHA is used as a research tool to study the role of nitric oxide in various biological processes. By inhibiting Arginase, NOHA can help researchers understand the effects of nitric oxide on cell signaling, inflammation, and other physiological functions. This can contribute to the development of new therapeutic strategies targeting nitric oxide pathways.
Used in Drug Delivery Systems:
NOHA can be incorporated into drug delivery systems to enhance the bioavailability and efficacy of nitric oxide. By improving the delivery of L-arginine, NOHA can potentially increase the production of nitric oxide, which may be beneficial in treating conditions where nitric oxide levels are compromised. This application can be particularly useful in the development of targeted therapies for specific diseases or conditions.

InChI:InChI=1/C6H14N4O3/c7-4(5(11)12)2-1-3-9-6(8)10-13/h4,13H,1-3,7H2,(H,11,12)(H3,8,9,10)/t4-/m0/s1

Upstream product

• 133374-43-3 N^α-(tert-butyloxycarbonyl)-N^ω-hydroxy-L-arginine tert-butyl ester 
• 3304-51-6 N-carboxybenzyl-L-ornithine 
• 133374-42-2 N^α-(tert-butoxycarbonyl)-N^δ-cyano-L-ornithine tert-butyl ester 
• 53054-01-6 (S)-2-amino-5-(((benzyloxy)carbonyl)amino)pentanoic acid tert-butyl ester 
• 53054-02-7 N_α-(1,1-dimethylethoxycarbonyl)-N_δ-(phenylmethoxycarbonyl)-L-ornithine 1,1-dimethylethyl ester 
• 53054-03-8 tert-butyl (2S)-5-amino-2-[(2-methylpropan-2-yl)oxycarbonylamino]pentanoate 

Downstream Products

• 372-75-8 Citrulline 
• 10024-97-2 dinitrogen monoxide 

Relevant articles and documents

Synthesis and bioactivity of N(ω)-hydroxyarginine: A possible intermediate in the biosynthesis of nitric oxide from arginine [1]

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