5302-39-6Relevant articles and documents
Gadolinium containing photochromic micelles as potential magnetic resonance imaging traceable drug carriers
Heta, Yushi,Kumaki, Kentaro,Hifumi, Hiroki,Citterio, Daniel,Tanimoto, Akihiro,Suzuki, Koji
, p. 876 - 883 (2012)
Novel photochromic amphipathic molecules, KMR-AZn (Gd-DTPA-AZCn), composed of hydrophilic Gd-DTPA and hydrophobic alkylated azobenzene were prepared. In aqueous environment, KMR-AZn indicated self-assembly. The resulting aggregates were demonstrated to be able to include a hydrophobic drug substitute (hydrophobic fluorescent dye) into the internal core, and to release the included compound upon photoirradiation within 10 min through the influence of azobenzene photoisomerization. This micellar MRI contrast agent exhibited three- to four-fold higher r1 relaxivity (r1 = 14.5-16.5 mm -1 s-1, 0.47 T at 40°C) than the widely applied small molecule contrast agent Gd-DTPA (Magnevistr1 = 4.1 mm-1 s-1, 0.47 T at 40°C). This dual functionality of encapsulated compound release and increased MR imaging contrast indicates that KMR-AZn is a potential candidate for application as a lipid-based MRI-traceable drug carrier.
Photoswitchable Antagonists for a Precise Spatiotemporal Control of β2-Adrenoceptors
Duran-Corbera, Anna,Catena, Juanlo,Otero-Vi?as, Marta,Llebaria, Amadeu,Rovira, Xavier
, p. 8458 - 8470 (2020/09/22)
β2-Adrenoceptors (β2-AR) are prototypical G-protein-coupled receptors and important pharmacological targets with relevant roles in physiological processes and diseases. Herein, we introduce Photoazolol-1-3, a series of photoswitchable azobenzene β2-AR ant
Synthesis and properties of phthalonitriles with an azo chromophore and related phthalocyanines
Tikhomirova,Badaukaite,Kulinich,Shaposhnikov
, p. 116 - 123 (2013/04/23)
The 4-R-phenylazophenoxyphthalonitriles were synthesized by the reaction of 4-bromophthalonitrile with 4-R-phenylazophenols and were used to obtain tetra-R-phenylazophenoxyphthalocyanines and their metal complexes. The effect of substituents on the spectr