526182-94-5 Usage
Description
Piperidine, 2-[2-(trifluoromethyl)phenyl]-, also known as 2-(2-(Trifluoromethyl)phenyl)piperidine, is an organic compound with the CAS number 526182-94-5. It is characterized by its unique molecular structure, which features a piperidine ring with a trifluoromethyl-substituted phenyl group attached to it. Piperidine, 2-[2-(trifluoromethyl)phenyl]is known for its potential applications in various fields, particularly in organic synthesis.
Uses
Used in Organic Synthesis:
Piperidine, 2-[2-(trifluoromethyl)phenyl]is used as an intermediate in the synthesis of various organic compounds. Its unique structure allows it to serve as a building block for the development of new molecules with specific properties and applications. The trifluoromethyl group in its structure imparts valuable characteristics to the synthesized compounds, making it a versatile component in organic chemistry.
Check Digit Verification of cas no
The CAS Registry Mumber 526182-94-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 5,2,6,1,8 and 2 respectively; the second part has 2 digits, 9 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 526182-94:
(8*5)+(7*2)+(6*6)+(5*1)+(4*8)+(3*2)+(2*9)+(1*4)=155
155 % 10 = 5
So 526182-94-5 is a valid CAS Registry Number.
InChI:InChI=1/C12H14F3N/c13-12(14,15)10-6-2-1-5-9(10)11-7-3-4-8-16-11/h1-2,5-6,11,16H,3-4,7-8H2
526182-94-5Relevant articles and documents
Using the competing enantioselective conversion method to assign the absolute configuration of cyclic amines with BODE’s acylation reagents
Dooley, Charles J.,Burtea, Alexander,Mitilian, Christina,Dao, Wendy T.,Qu, Bo,Salzameda, Nicholas T.,Rychnovsky, Scott D.
, p. 10750 - 10759 (2020/10/02)
The competing enantioselective conversion (CEC) method is a quick and reliable means to determine absolute configuration. Previously, Bode’s chiral acylated hydroxamic acids were used to determine the stereochemistry of primary amines, as well as cyclic and acyclic secondary amines. The enantioselective acylation has been evaluated for 4-, 5-, and 6-membered cyclic secondary amines, including medicinally relevant compounds. The limitations of the method were studied through computational analysis and experimental results. Piperidines with substituents at the 2-position did not behave well unless the axial conformer was energetically accessible, which is consistent with the transition state geometries proposed by Bode and Kozlowski. Control experiments were performed to investigate the cause of degrading selectivity under the CEC reaction conditions. The present study expands the scope of the CEC method for secondary amines and provides a better understanding of the reaction profile.
