5255-17-4 Usage
Description
3BETA-HYDROXY-DELTA5-CHOLENIC ACID, also known as Cholic Acid, is a monohydroxy bile acid derived from the oxidation of cholesterol. It plays a crucial role in the metabolism of primary bile acids, such as lithocholic acid and chenodeoxycholic acid, in humans. Cholic Acid is formed through the 7α-hydroxylation of 27-hydroxycholesterol and serves as a precursor in the biosynthesis of chenodeoxycholic acid. Its levels are elevated in patients with neonatal liver disease and those with intrahepatic and extrahepatic cholestasis.
Uses
Used in Pharmaceutical Industry:
3BETA-HYDROXY-DELTA5-CHOLENIC ACID is used as a therapeutic agent for treating various liver-related conditions, such as neonatal liver disease and cholestasis. Its application is based on its role in bile acid metabolism and its ability to alleviate symptoms associated with these conditions.
Used in Diagnostics:
In the medical field, 3BETA-HYDROXY-DELTA5-CHOLENIC ACID is used as a diagnostic marker to identify and monitor the progression of liver diseases, particularly in newborns and infants. The increased levels of this bile acid in patients with liver disorders help healthcare professionals in diagnosing and managing these conditions effectively.
Used in Research:
3BETA-HYDROXY-DELTA5-CHOLENIC ACID is also utilized in scientific research to study the metabolism of bile acids and their role in various physiological processes. This knowledge contributes to the development of new therapeutic strategies and a better understanding of liver function and related diseases.
Check Digit Verification of cas no
The CAS Registry Mumber 5255-17-4 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 5,2,5 and 5 respectively; the second part has 2 digits, 1 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 5255-17:
(6*5)+(5*2)+(4*5)+(3*5)+(2*1)+(1*7)=84
84 % 10 = 4
So 5255-17-4 is a valid CAS Registry Number.
InChI:InChI=1/C24H40O6/c1-12(4-7-21(29)30)14-5-6-15-22-16(10-20(28)24(14,15)3)23(2)11-19(27)17(25)8-13(23)9-18(22)26/h12-20,22,25-28H,4-11H2,1-3H3,(H,29,30)
5255-17-4Relevant articles and documents
Marine and semi-synthetic hydroxysteroids as new scaffolds for pregnane X receptor modulation
Sepe, Valentina,Di Leva, Francesco Saverio,D'Amore, Claudio,Festa, Carmen,De Marino, Simona,Renga, Barbara,D'Auria, Maria Valeria,Novellino, Ettore,Limongelli, Vittorio,D'Souza, Lisette,Majik, Mahesh,Zampella, Angela,Fiorucci, Stefano
, p. 3091 - 3115 (2014/07/08)
In recent years many sterols with unusual structures and promising biological profiles have been identified from marine sources. Here we report the isolation of a series of 24-alkylated-hydroxysteroids from the soft coral Sinularia kavarattiensis, acting as pregnane X receptor (PXR) modulators. Starting from this scaffold a number of derivatives were prepared and evaluated for their ability to activate the PXR by assessing transactivation and quantifying gene expression. Our study reveals that ergost-5-en-3β-ol (4) induces PXR transactivation in HepG2 cells and stimulates the expression of the PXR target gene CYP3A4. To shed light on the molecular basis of the interaction between these ligands and PXR, we investigated, through docking simulations, the binding mechanism of the most potent compound of the series, 4, to the PXR. Our findings provide useful functional and structural information to guide further investigations and drug design.
An efficient synthesis of cholanic acids from 20-ketopregnanes
Fukumoto,Suzuki,Nemoto,et al.
, p. 3701 - 3704 (2007/10/02)
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