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52457-99-5

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52457-99-5 Usage

Description

N-(2-propanoylphenyl)acetamide, also known as propionylphenylacetamide, is an organic compound with the chemical formula C11H13NO2. It is a white crystalline powder that is commonly used as an analgesic and antipyretic medication. This chemical is a derivative of acetanilide and is often used as a pain reliever and fever reducer. It works by inhibiting the production of prostaglandins, which are responsible for pain and inflammation. N-(2-propanoylphenyl)acetamide is also known for its mild sedative effects and is commonly found in over-the-counter medications to treat mild to moderate pain. However, it is important to use this chemical under the guidance of a healthcare professional to avoid any potential side effects.

Uses

Used in Pharmaceutical Industry:
N-(2-propanoylphenyl)acetamide is used as an analgesic and antipyretic agent for its ability to relieve pain and reduce fever. It is effective in treating mild to moderate pain and fever by inhibiting the production of prostaglandins, which are responsible for these symptoms.
Used in Over-the-Counter Medications:
N-(2-propanoylphenyl)acetamide is used as an active ingredient in over-the-counter medications to provide relief from mild to moderate pain and fever. Its mild sedative effects also contribute to its popularity in these products.

Check Digit Verification of cas no

The CAS Registry Mumber 52457-99-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,2,4,5 and 7 respectively; the second part has 2 digits, 9 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 52457-99:
(7*5)+(6*2)+(5*4)+(4*5)+(3*7)+(2*9)+(1*9)=135
135 % 10 = 5
So 52457-99-5 is a valid CAS Registry Number.
InChI:InChI=1/C11H13NO2/c1-3-11(14)9-6-4-5-7-10(9)12-8(2)13/h4-7H,3H2,1-2H3,(H,12,13)

52457-99-5Relevant articles and documents

INHIBITORS OF ENL/AF9 YEATS

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, (2021/06/26)

Methods and compositions for treating leukemia are disclosed. Acylated 6-aminoindoles, acylated 6-aminopyrrolopyridines and acylated 3-aminopyrrolo[3,2-c]pyridazines of the following formula inhibit ENL/AF9 YEATS and are therefore useful for treating leukemia.

FUSED BICYCLIC HETEROAROMATIC DERIVATIVES AS MODULATORS OF TNF ACTIVITY

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, (2015/06/25)

A series of substituted heteroaromatic compounds containing two fused six- membered rings,tivity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and ne

2-Arylaminopyrimidine derivatives as PLK inhibitors

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Page/Page column 51, (2010/02/14)

Anilino-pyrimidine and 1,2,4-triazine compounds (1) are new. Anilino-pyrimidine and 1,2,4-triazine compounds of formula (1), their tautomers, racemates, enantiomers and/or diastereomers and acid-addition salts are new. X : NR 1a>, O or S; Y : CH or N; Z : hydrogen, halo, (halo)1-3C alkyl, 2-3C alkenyl, 2-3C alkynyl, formyl, 1-3C (halo)alkylcarbonyl, 2-3C alkenyl-, 2-3C alkynyl-carbonyl or pseudohalo; A : (hetero)aryl group (i) or (ii); R a> - R f>e.g. hydrogen, halo or nitro; R 1> and R 1a>hydrogen or methyl; R 2>e.g. Cl, Br, I, OR 6>; R 3>e.g. -CONR 1>-L-Q 3-Q 4-R 9>, -NR 1>-CO-L-Q 3-Q 4-R 9>; R 4>e.g. OR 6>, COR 6>, CONR 6>R 7>, NR 6>R 7>, NR 6>COR 7>, NR 6>SO 2R 7>, N=CR 6>R 7>, SR 6>, SOR 6>, SO 2R 6>, SO 2NR 6>R 7> or pseudohalogen, or any of 1-8C alkyl, 2-10C alkenyl or alkynyl, 3-8C cycloalkyl, (hetero)aryl or heterocyclyl; R 5>hydrogen, halo, trifluoromethyl, 1-3C alkyl or OR 6>; R 6>, R 7>e.g. hydrogen or any of 1-5C alkyl, 2-5C alkenyl or alkynyl, 3-10C cycloalkyl, (hetero)aryl or heterocyclyl; L : e.g. bond or residue of 1-16C alkyl, 2-16C alkenyl or alkynyl, 3-10C cycloalkyl, (hetero)aryl or heterocyclyl; Q 3 and Q 4bond or a mono- or bi-cyclic heterocyclyl, optionally substituted by one or more of Me, Et, halo, amino, hydroxy or pseudohalo; R 9>as L but not a bond; and T : N, O or S. Full definitions are given in the DEFINITIONS (Full Definitions) field. [Image] [Image] ACTIVITY : Cytostatic; Antiinflammatory; Immunosuppressive; Virucide; Anti-HIV; Dermatological; Nootropic; Neuroprotective; Nephrotropic; Vulnerary; Antibacterial; Fungicide; Antiparasitic; Antipsoriatic; Osteopathic; Cardiovascular-Gen; Vasotropic; Gastrointestinal-Gen. MECHANISM OF ACTION : Kinase inhibitor; Polo-like kinase (PLK) inhibitor. In a trial, (1) was found to have EC 50 against recombinant human PLK1 of below 5, generally 1 mu M. No results for specific compounds were given.

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