521985-03-5

Basic information

• Product Name: 3,4,5,6-tetrahydro-2H-[1,2]bipyrazinyl-5'-carboxylic acid methyl ester
• Synonyms: 3,4,5,6-tetrahydro-2H-[1,2]bipyrazinyl-5'-carboxylic acid methyl ester
• CAS NO: 521985-03-5
• Molecular Weight: 222.247
• Mol File: 521985-03-5.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 418.6±45.0 °C(Predicted)
• Density: 1.220±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 3,4,5,6-tetrahydro-2H-[1,2]bipyrazinyl-5'-carboxylic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 3,4,5,6-tetrahydro-2H-[1,2]bipyrazinyl-5'-carboxylic acid methyl ester(521985-03-5)
• EPA Substance Registry System: 3,4,5,6-tetrahydro-2H-[1,2]bipyrazinyl-5'-carboxylic acid methyl ester(521985-03-5)

Safety Data

• Hazardous Substances Data: 521985-03-5(Hazardous Substances Data)

Upstream product

• 110-85-0 piperazine 
• 33332-25-1 methyl 5-chloropyrazine-2-carboxylate 

Downstream Products

• 521985-04-6 5-{4-[(1,5-dimethyl-2-phenyl-1H-indol-3-yl)carbonyl]piperazin-1-yl}-2-(carbomethoxy)pyrazine 
• 521985-08-0 methyl 5-{4-[(5-methyl-6-phenyl-5H-pyrrolo[2,3-b]pyrazin-7-yl)carbonyl]piperazin-1-yl}pyrazine-2-carboxylate 
• 521985-15-9 methyl 5-{4-[(1-methyl-2-phenyl-1H-pyrrolo[3,2-b]pyridin-3-yl)carbonyl]piperazin-1-yl}pyrazine-2-carboxylate 

Relevant articles and documents

AMIDE DERIVATIVES AND DRUGS

The present invention provides an amide derivative represented by the following formula [1]: wherein n represents 0 or 1; X represents CR4 or N; Y represents CR6 or N; Z represents CR7 or N; R1 and R2 may be the same or different and each represents hydrogen, optionally substituted alkyl, acyl, optionally substituted aryl, or an optionally substituted aromatic heterocyclic group; R4, R5, R6 and R7 may be the same or different and each represents hydrogen, halogen, hydroxy, amino, alkyl, haloalkyl, alkoxy, monoalkylamino, dialkylamino, arylalkyl, cyano, or nitro; and R3 represents optionally substituted alkylamino, optionally substituted arylamino, or optionally substituted cyclic amino, or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition comprising them as an active ingredient. The compound of the present invention is useful as a TGF-β inhibitor.