5216-25-1 Usage
Description
4-Chlorobenzotrichloride, also known as p-Chlorobenzotrichloride, is an organochloride compound that exists as a clear, colorless liquid. It is characterized by its flammable nature and is widely utilized in various applications due to its unique chemical properties.
Uses
4-Chlorobenzotrichloride is used as a reactant in the field of organic synthesis for its versatile chemical properties, which allow it to participate in a range of reactions and contribute to the formation of different compounds.
Used in Chemical Synthesis:
4-Chlorobenzotrichloride is used as a building block in the chemical synthesis industry for the production of various organic compounds. Its reactivity and stability make it a valuable component in the synthesis of pharmaceuticals, agrochemicals, and other specialty chemicals.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 4-Chlorobenzotrichloride is used as an intermediate in the synthesis of various drugs. Its unique structure allows for the development of new drug candidates with potential therapeutic applications.
Used in Agrochemical Industry:
4-Chlorobenzotrichloride is also utilized in the agrochemical industry for the synthesis of pesticides and other crop protection agents. Its chemical properties enable the creation of compounds that can effectively control pests and diseases in agriculture.
Air & Water Reactions
Insoluble in water.
Reactivity Profile
Simple aromatic halogenated organic compounds, such as 4-Chlorobenzotrichloride , are very unreactive. Reactivity generally decreases with increased degree of substitution of halogen for hydrogen atoms. Materials in this group may be incompatible with strong oxidizing and reducing agents. Also, they may be incompatible with many amines, nitrides, azo/diazo compounds, alkali metals, and epoxides.
Health Hazard
ACUTE/CHRONIC HAZARDS: Corrosive; Lachrymator.
Fire Hazard
Flash point data for 4-Chlorobenzotrichloride are not available, however, 4-Chlorobenzotrichloride is probably combustible.
Flammability and Explosibility
Notclassified
Safety Profile
Suspected carcinogen.
A poison by inhalation. Moderately toxic by
ingestion and skin contact. When heated to
decomposition it emits toxic vapors of Cl-.
Potential Exposure
Used in agrochemicals manufacture as
an intermediate; reaction with HF yields chlorobenzotrifluoride as a major intermediate for several pesticides;
for making pharmaceuticals; UV absorbers, and dyestuffs.
This chemical is manufactured in high volume (exceeds 1
million pounds per annum) in the United States.
Incompatibilities
A halogenated aromatic compound.
Hydrolyzes to hydrochloric acid and benzoic acid in all
forms of moisture. Incompatible with strong oxidizers
(chlorates, nitrates, peroxides, permanganates, perchlorates,
chlorine, bromine, fluorine, etc.); contact may cause fires
or explosions. Keep away from reducing agents, alkaline
materials, strong acids, strong bases, amines, nitrides, azo/
diazo compounds, alkali metals, and epoxides.
Check Digit Verification of cas no
The CAS Registry Mumber 5216-25-1 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 5,2,1 and 6 respectively; the second part has 2 digits, 2 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 5216-25:
(6*5)+(5*2)+(4*1)+(3*6)+(2*2)+(1*5)=71
71 % 10 = 1
So 5216-25-1 is a valid CAS Registry Number.
InChI:InChI=1/C7H4Cl4/c8-6-3-1-5(2-4-6)7(9,10)11/h1-4H
5216-25-1Relevant articles and documents
Novel synthetic method of halogenated aromatic hydrocarbon
-
Paragraph 0017; 0021; 0025; 0029, (2020/01/25)
The invention discloses a novel synthetic method of halogenated aromatic hydrocarbon, wherein p-chlorotoluene is used as a raw material, copper chloride or cuprous chloride is used as a catalyst, andp-chlorobenzotrifluoride is synthesized through two steps of chlorination and fluorination. Compared with the method in the prior art, the method of the invention has the following characteristics that raw materials are subjected to heating dehydration treatment in a dehydration kettle, so that the chlorination side reactions are few, the product purity is high, the grading chlorination device does not need to be additionally arranged, the technological process is simple, and the operation is convenient; and by adding the catalyst in batches in the chlorination process, the use efficiency of the catalyst is improved, so that the emission of the byproducts and the waste gas generated by the chlorination reaction in production is greatly reduced, and the emission of pollutants in the production process is reduced.
Synthesis method of 4-chlorobenzotrifluoride
-
Paragraph 0020; 0024; 0028; 0032, (2019/12/02)
The invention discloses a synthetic method of 4-chlorobenzotrifluoride. P-chlorotoluene is used as a raw material, and 4-chlorobenzotrifluoride is synthesized through two steps of chlorination and fluorination. Compared with the prior art, the raw materials are subjected to heating dehydration treatment in the dehydration kettle, chlorination side reactions are few, the product purity is high, a graded chlorination device does not need to be added, the technological process is simple, and operation is convenient; according to the chlorination process, a mode of adding the catalyst in batches is adopted, so that the use efficiency of the catalyst is improved, the emission of byproducts and waste gas generated by chlorination reaction in production is greatly reduced, and the emission of pollutants in the production process is reduced.
PhPOCl2as a potent catalyst for chlorination reaction of phenols with PCl5
Wu, Jiang,Zhou, Junpeng,Shi, Yalei,Zhu, Jintao
supporting information, p. 1619 - 1624 (2016/10/09)
Phenols are easily converted to the corresponding aryl chlorides by using phosphorus pentachloride (PCl5) and a catalytic amount of phenylphosphonic dichloride (PhPOCl2), which is a new efficient method for synthesis of aryl chloride in good yields.
