52092-47-4 Usage
Description
5-Chloro-2-nitropyridine is an organic compound that serves as a crucial intermediate in the synthesis of various organic and pharmaceutical compounds. It is characterized by its unique molecular structure, which features a chlorine atom at the 5th position and a nitro group at the 2nd position on a pyridine ring. 5-Chloro-2-nitropyridine is known for its reactivity and versatility in chemical reactions, making it a valuable component in the development of new molecules with potential applications in various fields.
Uses
Used in Organic Synthesis:
5-Chloro-2-nitropyridine is used as an organic synthesis intermediate for the creation of a wide range of chemical compounds. Its unique structure allows for various functional group transformations, enabling the synthesis of complex molecules with diverse properties and applications.
Used in Pharmaceutical Intermediates:
In the pharmaceutical industry, 5-Chloro-2-nitropyridine is utilized as a key intermediate in the development of new drugs. Its reactivity and structural diversity make it an essential component in the design and synthesis of novel therapeutic agents, particularly those targeting specific biological pathways or receptors.
Used in Laboratory Research and Development:
5-Chloro-2-nitropyridine is also employed in laboratory research and development processes, where it is used to explore new reaction pathways, optimize synthetic routes, and develop innovative methodologies for the synthesis of complex organic and pharmaceutical compounds.
Used in Chemical Production Process:
In the chemical production process, 5-Chloro-2-nitropyridine plays a vital role in the large-scale synthesis of various organic and pharmaceutical compounds. Its use in this context helps to streamline the production process, improve yields, and enhance the overall efficiency of the manufacturing process.
Synthesis
To concentrated H2SO4 (50 ml) was added 30 % H2O2 (25mL) at 0 °C and a solution of 5-chloropyridin-2-amine (5.0 g, 39 mmol) in concentrated H2SO4 (20 mL) was added at 0 °C. The mixture was stirred for 20 hours at room temperature. The mixture was poured into ice water under vigorously stirring and the resulting solid was filtered. The solid was recrystallized from ethanol to give 5-chloro-2-nitropyridine. 5-chloro-2-nitropyridine. MS m/z 159 (M+ 1)+.
Check Digit Verification of cas no
The CAS Registry Mumber 52092-47-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,2,0,9 and 2 respectively; the second part has 2 digits, 4 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 52092-47:
(7*5)+(6*2)+(5*0)+(4*9)+(3*2)+(2*4)+(1*7)=104
104 % 10 = 4
So 52092-47-4 is a valid CAS Registry Number.
InChI:InChI=1/C5H3ClN2O2/c6-4-1-2-5(7-3-4)8(9)10/h1-3H
52092-47-4Relevant articles and documents
INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL
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Paragraph 0217, (2016/09/26)
no abstract published
INHIBITORS OF RENAL OUTER MEDULLARY POTASSIUM CHANNEL
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Page/Page column 64, (2015/07/15)
Novel spirocyclic compounds of formula I: and pharmaceutically acceptable salts thereof are disclosed as inhibitors of the ROMK (Kir1.1) channel. The compounds may be used as diuretic and/or natriuretic agents and for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension, heart failure and chronic kidney disease and conditions associated with excessive salt and water retention. Pharmaceutical compositions and methods of treatment are also included.
Amide compounds and medications containing the same technical field
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Page/Page column 145, (2010/02/10)
The present invention provides to a novel compound having an ACAT inhibiting activity. The present invention relates to compounds represented by formula (I) wherein represents an optionally substituted divalent residue such as benzene, pyridine, cyclohexane or naphthalene, or a group,Het represents a 5- to 8-membered, substituted or unsubstituted heterocyclic group containing at least one heteroatom selected from the group consisting of a nitrogen atom, an oxygen atom and a sulfur atom, such as a monocyclic group, a polycyclic group or a group of a fused ring,X represents —NH—, an oxygen atom or a sulfur atom,Y represents —NR4—, an oxygen atom, a sulfur atom, a sulfoxide or a sulfone,Z represents a single bond or —NR5—,R4 represents a hydrogen atom, a lower alkyl group, an aryl group or an optionally substituted silyl lower alkyl group,R5 represents a hydrogen atom, a lower alkyl group, an aryl group or an optionally substituted silyl lower alkyl group, andn is integer of from 1 to 15, or salts or solvates thereof, and a pharmaceutical composition containing at one of these compounds.
