52072-37-4

Basic information

• Product Name: α-hexyl deoxybenzoin
• Synonyms: α-hexyl deoxybenzoin
• CAS NO: 52072-37-4
• Molecular Weight: 280.41
• Mol File: 52072-37-4.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: α-hexyl deoxybenzoin(CAS DataBase Reference)
• NIST Chemistry Reference: α-hexyl deoxybenzoin(52072-37-4)
• EPA Substance Registry System: α-hexyl deoxybenzoin(52072-37-4)

Safety Data

• Hazardous Substances Data: 52072-37-4(Hazardous Substances Data)

Upstream product

• 451-40-1 phenyl benzyl ketone 
• 111-27-3 hexan-1-ol 
• 38821-25-9 α-octyl deoxybenzoin 
• 638-45-9 1-Iodohexane 
• 21383-02-8 α-propyl deoxybenzoin 
• 1418731-62-0 (R)-α-octyl deoxybenzoin 
• 1418731-60-8 (R)-α-propyl deoxybenzoin 
• 1418731-59-5 C₂₂H₃₀O 
• 1032819-01-4 (1R,2R)-1,2-diphenylpentan-1-ol 
• 93790-54-6 [2-(4-iodophenoxy)ethyl]dimethylamine 

Downstream Products

• 2042-85-5 1,2-diphenylpropan-1-one 
• 7693-84-7 (1R,2R)-1,2-diphenyl-propan-1-ol 
• 1418731-58-4 C₂₀H₂₆O 
• 1418731-59-5 C₂₂H₃₀O 
• 58751-83-0 1,2-diphenylpropan-1-one 
• 1418731-61-9 (R)-α-hexyl deoxybenzoin 
• 1418731-62-0 (R)-α-octyl deoxybenzoin 
• 29492-95-3 6,7-diphenyl-dodecane 
• 451-40-1 phenyl benzyl ketone 
• 1857-74-5 2,3-diphenylbutane 
• 134-81-6 benzil 
• 18220-90-1 4-ethylbenzophenone 
• 38821-25-9 α-octyl deoxybenzoin 

Relevant articles and documents

NNN pincer Ru(II)-complex-catalyzed α-alkylation of ketones with alcohols

A series of novel ruthenium(II) complexes supported by a symmetrical NNN ligand were prepared and fully characterized. These complexes exhibited good performance in transfer hydrogenation to form new C-C bonds using alcohols as the alkylating agents, generating water as the only byproduct. A broad range of substrates, including (hetero)aryl- or alkyl-ketones and alcohols, were well tolerated under the optimized conditions. Notably, α-substituted methylene ketones were also investigated, which afforded α-branched steric hindrance products. A potential application of α-alkylation of methylene acetone to synthesize donepezil was demonstrated, which provided the desired product in 83% yield. Finally, this catalytic system could be applied to a one-pot double alkylation procedure with sequential addition of two different alcohols. The current protocol is featured with several characteristics, including a broad substrate scope, low catalyst (0.50 mol %) loadings, and environmental benignity.

Carbolithiation of diphenylacetylene as a stereoselective route to (Z)-tamoxifen and related tetrasubstituted olefins

(Chemical Equation Presented) Carbolithiation of diphenylacetylene can be exploited to generate (E)-1-lithio-1,2-diphenylalkyl-1-enes which can be reacted in situ with triisopropylborate to stereoselectively provide (E)-1,2-diphenyl-1-alkylene boronic acids. These tetrasubstituted vinylboronic acids served as versatile intermediates for the generation of tetrasubstituted olefins with retention of stereochemistry. The application of this method for the stereoselective synthesis of (Z)-tamoxifen and related analogues is described.