52-49-3 Usage
Description
Benzhexol hydrochloride, also known as Trihexyphenidyl hydrochloride, is a white solid that functions as an anticholinergic tertiary amine. It is an antagonist of M1 muscarinic acetylcholine receptors and has pharmacological actions and side effects that qualitatively resemble the belladonna alkaloids. Benzhexol hydrochloride is approximately half as active as atropine as an antispasmodic but is claimed to have milder side effects.
Uses
Used in Parkinsonism Treatment:
Benzhexol hydrochloride is used as an antiparkinsonian agent for treating parkinsonism and the extrapyramidal side effects of anti-psychotic drugs. It provides relief from the mental depression often associated with parkinsonism and improves abnormal movement in a mouse model of L-3,4-dihydroxyphenylalanine (L-DOPA) responsive dystonia (DRD).
Used in Anticholinergic Applications:
Benzhexol hydrochloride is used as an anticholinergic agent for its ability to inhibit contractions induced by acetylcholine in guinea pig ileum and to prevent oxotremorine-induced tremors and physostigmine-induced mortality in mice. It selectively binds to rat M1 receptors in cerebral cortex over rat M2 receptors in heart tissue, making it a useful compound in the treatment of various conditions related to the muscarinic acetylcholine receptors.
Therapeutic Function
Antiparkinsonian
Safety Profile
Poison by ingestion,intraperitoneal, intravenous, and subcutaneous routes. Ananticholinergic agent which causes human psychotropiceffects. Human systemic effects by ingestion: distortedperceptions, eye effects, hallucinations, toxic psychosis.When he
Check Digit Verification of cas no
The CAS Registry Mumber 52-49-3 includes 5 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 2 digits, 5 and 2 respectively; the second part has 2 digits, 4 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 52-49:
(4*5)+(3*2)+(2*4)+(1*9)=43
43 % 10 = 3
So 52-49-3 is a valid CAS Registry Number.
InChI:InChI=1/C20H31NO.2ClH/c22-20(18-10-4-1-5-11-18,19-12-6-2-7-13-19)14-17-21-15-8-3-9-16-21;;/h1,4-5,10-11,19,22H,2-3,6-9,12-17H2;2*1H
52-49-3Relevant articles and documents
Synthetic method of diphenhydrazide hydrochloride
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Paragraph 0015-0019, (2020/11/22)
The invention discloses a synthetic method of diphenhydrazide hydrochloride, and researches find that the yield of a diphenhydrazide hydrochloride crude product is more than 85% by using a mixed solvent of methyl tert-butyl ether and ethylene glycol dimethyl ether and adjusting specific parameters and an operation method of a production process at the same time. The purity of the crude diphenhydrazol hydrochloride product is greater than 98%. According to the method, the yield and quality of diphenhydrazide hydrochloride are greatly improved, the production is safer, and the industrializationis facilitated.
Aryl-cycloalkyl-alkanolamines for treatment of neurotoxic injury
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, (2008/06/13)
Compounds, compositions and methods of treatment are described to control brain damage associated with anoxia or ischemia which typically follows such conditions as stroke, cardiac arrest or perinatal asphyxia. The treatment includes administration of an aryl-cycloalkyl-alkanolamine compound as an antagonist to inhibit excitotoxic actions at major neuronal excitatory amino acid receptor sites.
