51560-21-5

Basic information

• Product Name: 1,4-DIIODO-2,5-DIMETHOXYBENZENE
• Synonyms: 1,4-DIIODO-2,5-DIMETHOXYBENZENE;2,5-DIIODO-1,4-DIMETHOXYBENZENE;2,5-DIMETHOXY-1,4-DIIODOBENZENE;Benzene, 1,4-diiodo-2,5-dimethoxy-;2,5-Diiodo-1,4-dimethoxybenzene 2,5-Dimethoxy-1,4-diiodobenzene;1,4-diiodo-2,5-bis(methoxy)benzene
• CAS NO: 51560-21-5
• Molecular Formula: C₈H₈I₂O₂
• Molecular Weight: 389.96
• Mol File: 51560-21-5.mol
• Article Data: 8

Chemical Properties

• Melting Point: 171 °C
• Boiling Point: 382.9 °C at 760 mmHg
• Flash Point: 185.4 °C
• Appearance: /
• Density: 2.147 g/cm³
• Vapor Pressure: 1.01E-05mmHg at 25°C
• Refractive Index: 1.64
• Storage Temp.: 2-8°C(protect from light)
• CAS DataBase Reference: 1,4-DIIODO-2,5-DIMETHOXYBENZENE(CAS DataBase Reference)
• NIST Chemistry Reference: 1,4-DIIODO-2,5-DIMETHOXYBENZENE(51560-21-5)
• EPA Substance Registry System: 1,4-DIIODO-2,5-DIMETHOXYBENZENE(51560-21-5)

Safety Data

• Hazard Codes: Xi
• Statements: R36/37/38:Irritating to eyes, respiratory system and skin.
• Safety Statements: S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.; S37/39:Wear suitable g
• Hazardous Substances Data: 51560-21-5(Hazardous Substances Data)

Usage

General Description

1,4-DIIODO-2,5-DIMETHOXYBENZENE is a chemical compound with the molecular formula C8H8I2O2. It belongs to the class of organic compounds known as dihalobenzenes, which are aromatic compounds containing two halogen atoms bonded to a benzene ring. 1,4-DIIODO-2,5-DIMETHOXYBENZENE is a derivative of dimethoxybenzene and contains two iodine atoms substituted on the 1 and 4 positions of the benzene ring. It is primarily used in organic synthesis, particularly in the preparation of pharmaceuticals, agrochemicals, and other fine chemicals. Its unique structure and properties make it a valuable building block in the production of various chemical compounds. Additionally, it is important to handle this compound carefully, as iodine-containing chemicals can be toxic and hazardous if not used properly.

InChI:InChI=1/C8H8I2O2/c1-11-7-3-6(10)8(12-2)4-5(7)9/h3-4H,1-2H3

Upstream product

• 25245-35-6 1-iodo-2,4-dimethoxybenzene 
• 150-78-7 1,4-dimethoxybezene 
• 3899-91-0 4-methoxyphenyl p-toluenesulfonate 
• 98279-45-9 3-iodo-4-methoxyphenol 
• 186134-37-2 3-iodo-4-methoxyphenyl 4-methylbenzenesulfonate 
• 91-16-7 1,2-dimethoxybenzene 
• 102-56-7 2,5-dimethoxyaniline 

Downstream Products

• 78889-40-4 1,4-Dimethoxy-2,5-bis-(4-nitro-phenylethynyl)-benzene 
• 78889-43-7 2,5-bis(3'-N-morpholino-1'-propynyl)-1,4-dimethoxybenzene 
• 78889-39-1 2,5-bis(3'-hydroxy-3'-methyl-1'-butynyl)-1,4-dimethoxybenzene 
• 6301-35-5 1-iodo-2,5-dimethoxy-4-nitro-benzene 
• 842120-12-1 1-hydroxy-2,5-diiodo-4-methoxybenzene 
• 357396-86-2 4-(hexyloxy)-2,5-diiodophenol 
• 911307-60-3 2,5-diiodo-4-octyloxyphenol 
• 1001907-79-4 1,4-bis-{4-[β-(dimethylsilanyl)vinyl]styryl}-2,5-dimethoxybenzene 
• 637036-63-6 [2-(4-Hexyloxy-2,5-diiodo-phenoxy)-ethyl]-methyl-{4-[(E)-2-(4-nitro-phenyl)-vinyl]-phenyl}-amine 

Relevant articles and documents

Practical electrochemical iodination of aromatic compounds

A practical method for electrochemical iodination of aromatic compounds was developed. The method involves the generation of I+ by electrochemical oxidation of I2 in CH3CN using H 2SO4 as supporting electrolyte followed by the reaction with aromatic compounds. The para/ortho selectivity for the reaction of mono-substituted benzenes was significantly improved using dimethoxyethane as cosolvent in the second step. The reaction with highly reactive aromatic compounds led to the formation of significant amounts of diiodo compounds in a macrobatch reactor. This problem was solved by fast 1:1 mixing of I+ with an aromatic compound using a microflow system consisting of a T-shaped micromixer and a microtube reactor.

PROCESS FOR PRODUCING AROMATIC IODINE COMPOUND

A process for producing an aromatic iodine compound. It has advantages of ease of handling and high safety. By the process, the reaction product having an excellent color tone can be produced in a high yield. The process for aromatic iodine compound production is characterized by introducing an aromatic compound and an active iodizing agent into a flow-through type reactor equipped with a high-speed mixer to continuously replace hydrogen atoms of the aromatic nucleus of the aromatic compound with iodine atoms.

A facile synthesis of 1,4-dialkoxy-2,5-diiodobenzenes: reaction of dialkoxybenzenes with iodine monochloride in alcoholic solvents

A facile synthesis of 1,4-dialkoxy-2,5-diiodobenzenes via diiodination of the corresponding dialkoxybenzenes with iodine monochloride has been developed. Employment of ah alcoholic solvent as a reaction medium is crucial for attaining a high yield; the reaction in a nonalcoholic solvent usually resulted in a poor yield. The diiodobenzene derivatives are useful intermediates in the synthesis of such advanced materiais as soluble phenylenevinylene polymers anal dialkoxy derivatives of 7,7,8,8-tetracyanoquinodimethane.