51544-78-6

Basic information

• Product Name: Z-3-bromo-1-cyano-1-propene
• CAS NO: 51544-78-6
• Molecular Weight: 145.986
• Mol File: 51544-78-6.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Z-3-bromo-1-cyano-1-propene(CAS DataBase Reference)
• NIST Chemistry Reference: Z-3-bromo-1-cyano-1-propene(51544-78-6)
• EPA Substance Registry System: Z-3-bromo-1-cyano-1-propene(51544-78-6)

Safety Data

• Hazardous Substances Data: 51544-78-6(Hazardous Substances Data)

Upstream product

• 4786-20-3 but-2-enenitrile 
• 109-75-1 but-3-enenitrile 
• 56-23-5 tetrachloromethane 
• 128-08-5 N-Bromosuccinimide 
• 94-36-0 dibenzoyl peroxide 
• 4786-20-3 crotononitrile 
• 1190-76-7 (Z)-2-butenenitrile 

Downstream Products

• 640737-18-4 C₁₁H₉NO₂ 

Relevant articles and documents

One-Step Synthesis of 3,4-Disubstituted 2-Oxazolidinones by Base-Catalyzed CO2 Fixation and Aza-Michael Addition

2-Oxazolidinones are saturated heterocyclic compounds, which are highly attractive targets in modern drug design. Herein, we describe a new, single-step approach to 3,4-disubstituted 2-oxazolidinones by aza-Michael addition using CO2 as a carbonyl source and 1,1,3,3-tetramethylguanidine (TMG) as a catalyst. The modular reaction, which occurs between a γ-brominated Michael acceptor, CO2 and an arylamine, aliphatic amine or phenylhydrazine, is performed under mild conditions. The regiospecific reaction displays good yields (av. 75 %) and excellent functional-group compatibility. In addition, late-stage functionalization of drug and drug-like molecules is demonstrated. The experimental results suggest a mechanism consisting of several elementary steps: TMG-assisted carboxylation of aniline; generation of an O-alkyl carbamate; and the final ring-forming step through an intramolecular aza-Michael addition.

KRAS G12C INHIBITORS

The present invention relates to compounds that inhibit KRas G12C. In particular, the present invention relates to compounds that irreversibly inhibit the activity of KRas G12C, pharmaceutical compositions comprising the compounds and methods of use therefor.