514-47-6

Basic information

• Product Name: euphol
• Synonyms: Lanosta-8,24-dien-3-ol,(3b,13a,14b,17a)-;euphol;Euphol, Euphadienol;(13α,14β,17α)-5α-Lanosta-8,24-dien-3β-ol;Euphadienol;alpha-Eupho
• CAS NO: 514-47-6
• Molecular Formula: C30H50O
• Molecular Weight: 426.724
• Mol File: 514-47-6.mol
• Article Data: 3

Chemical Properties

• Melting Point: 116-117℃
• Boiling Point: 498.9°Cat760mmHg
• Flash Point: 221.1°C
• Appearance: /
• Density: 0.98±0.1 g/cm3 (20 ºC 760 Torr)
• Vapor Pressure: 4.83E-12mmHg at 25°C
• Refractive Index: 1.53
• PKA: 15.16±0.70(Predicted)
• CAS DataBase Reference: euphol(CAS DataBase Reference)
• NIST Chemistry Reference: euphol(514-47-6)
• EPA Substance Registry System: euphol(514-47-6)

Safety Data

• Hazardous Substances Data: 514-47-6(Hazardous Substances Data)

Usage

Description

Euphol, also known as Euphadienol, is an alcohol tetracyclic triterpene derived from natural sources. It possesses various biological activities, including anti-inflammatory, antiproliferative, antinociceptive, and anti-neoplastic properties, making it a versatile compound with potential applications in various industries.

Uses

Used in Pharmaceutical Industry:
Euphol is used as an anti-inflammatory agent for its ability to reduce and limit the severity and development of experimental autoimmune encephalomyelitis (EAE), which serves as an established model for Multiple Sclerosis (MS). Its anti-inflammatory action makes it a promising candidate for the development of new treatments for MS and other inflammatory conditions.
Euphol is also used as an anti-neoplastic agent due to its potential to inhibit the growth and proliferation of cancer cells. Its antiproliferative properties make it a candidate for further research and development in the field of oncology.
Used in Veterinary Medicine:
In veterinary medicine, euphol is used as an autonomic pressor and depressor agent. It has been found to inhibit various autonomic responses in dogs and rats, which could be useful in the management of certain conditions in animals.

InChI:InChI=1/C30H50O/c1-20(2)10-9-11-21(3)22-14-18-30(8)24-12-13-25-27(4,5)26(31)16-17-28(25,6)23(24)15-19-29(22,30)7/h10,21-22,25-26,31H,9,11-19H2,1-8H3/t21-,22+,25+,26+,28-,29+,30-/m1/s1

Upstream product

• 64-17-5 ethanol 
• 50719-45-4 24-bromo-euphadien-(8.24)-ol-(3β) 
• 5539-04-8 lanostenone-3 
• 14050-42-1 2,3-Oxidosqualene 

Downstream Products

• 2671-68-3 euphol acetate 
• 106766-75-0 eupha-8,24-dien-3-one-(2,4-dinitro-phenylhydrazon); euphone-(2,4-dinitro-phenylhydrazone) 
• 54411-45-9 euphene-(8)-dione-(7.11) 
• 1724-19-2 Tirucall-8-enyl-acetat 
• 38602-31-2 Euph-8-enylacetat 
• 35963-37-2 (22R)-3β,22-Dihydroxylanosta-8,24-diene 
• 2671-68-3 euphol acetate 
• 13879-05-5 3β-benzoyloxy-eupha-8,24-diene 

Relevant articles and documents

PROCESS FOR THE PREPARATION OF LANOSTA-8-ENE COMPOU

The present invention concerns a process for the preparation of lanosta-8-ene compounds having lanosta-8-ene-7-one or lanosta-8-ene-7-ol compounds as starting material.

Une voie d'acces a la trimethyl-4,4,7a tetrahydro-3aα,4,7,7aα (3H)-benzofurannone-2 a partir des alcoxy-5 trimethyl-4,4,7a hexahydro-3aα,4,5,6,7,7aα (3H)-benzofurannones-2

The 5-hydroxy 4,4,7a-trimethyl 3aα, 4,5,6,7,7aα-hexahydro (3H)-benzofuran-2-ones are obtained by cleavage of the corresponding methyl or ethyl ethers with iodotrimethylsilane.The two hydroxylactones 5 and 6 are transformed into sulfonic esters as a step towards the dehydrated lactone 7, without squeletal rearrangement.Solvolysis of the tosylate and the mesylate of 5, a cis-fused ring lactone, proceeds by completely different ways under analogous experimental procedures.Results are explained and compared to the solvolysis of some triterpenes.Experimental procedures for ether cleavage are discussed and the intermediates or by-products of these reactions are identified.