514-33-0 Usage
Description
(20S)-3β,16β-Dihydroxy-5α-pregnane-20-carboxylic acid γ-lactone is a chemical compound that belongs to the class of pregnane steroids. It is a derivative of progesterone and is formed by the addition of a carboxylic acid and a lactone group to the steroid backbone. (20S)-3β,16β-Dihydroxy-5α-pregnane-20-carboxylic acid γ-lactone has potential biological activity and may have pharmacological effects, especially in relation to hormone regulation and reproductive function.
Uses
Used in Pharmaceutical Industry:
(20S)-3β,16β-Dihydroxy-5α-pregnane-20-carboxylic acid γ-lactone is used as a pharmaceutical agent for its potential hormone regulation and reproductive function effects. Its ability to modulate hormone levels and influence reproductive processes makes it a promising candidate for the development of medications targeting hormonal imbalances and fertility issues.
Used in Research Applications:
In the field of scientific research, (20S)-3β,16β-Dihydroxy-5α-pregnane-20-carboxylic acid γ-lactone serves as a valuable tool for studying the mechanisms of hormone regulation and the role of steroids in reproductive function. Its unique structure and potential biological activity provide researchers with insights into the complex interactions between hormones and their target tissues, contributing to a better understanding of related physiological processes.
Further research is needed to fully understand the properties and potential uses of (20S)-3β,16β-Dihydroxy-5α-pregnane-20-carboxylic acid γ-lactone in medicine and other fields. Its exploration may lead to the discovery of new therapeutic applications and a deeper comprehension of the underlying biological processes.
Check Digit Verification of cas no
The CAS Registry Mumber 514-33-0 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 5,1 and 4 respectively; the second part has 2 digits, 3 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 514-33:
(5*5)+(4*1)+(3*4)+(2*3)+(1*3)=50
50 % 10 = 0
So 514-33-0 is a valid CAS Registry Number.
InChI:InChI=1/C22H34O3/c1-12-19-18(25-20(12)24)11-17-15-5-4-13-10-14(23)6-8-21(13,2)16(15)7-9-22(17,19)3/h12-19,23H,4-11H2,1-3H3/t12-,13-,14-,15+,16-,17-,18-,19-,21-,22-/m0/s1
514-33-0Relevant articles and documents
Synthesis of "glycospirostanes" via ring-closing metathesis
Czajkowska, Dorota,Morzycki, Jacek W.,Santillan, Rosa,Siergiejczyk, Leszek
, p. 1073 - 1079 (2009)
Syntheses of "glycospirostanes" from 3β-hydroxy-23,24-dinor-5α-cholano-22,16-lactone and 3α-hydroxy-23,24-dinor-5β-cholano-22,16-lactone were performed. The key step of these syntheses was ring-closing metathesis of the corresponding C,O-diallyl derivativ
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Marker,Rohrmann
, p. 1291 (1939)
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Mechanistic studies of the rearrangements of steroidal 16,17-ketols and syntheses of 20→16-cis-γ-carbolactones
Bruttomesso, Andrea C.,Doller, Dario,Gros, Eduardo G.
, p. 943 - 947 (1999)
Utilization of 17-keto-androstanes as starting materials for the synthesis of α- or β-oriented steroidal 20→16-γ-carbolactones has been explored following two different strategies. A highly efficient, stereospecific protocol has been developed for the β-oriented cis-γ-lactone. A different approach, involving prior attachment of a 3-carbon side chain on C-17 of a 17-oxo-16β-acetoxy-androstane led to the epimeric, α-oriented lactone. The mechanism of the rearrangement of epimeric 16β- or 16α-hydroxy-17-keto-androstanes to 17β-hydroxy-16-keto-androstanes was studied by 13C NMR spectroscopy. The former occurs through a 1,2-sigmatropic H-shift, while the latter is likely to take place by simple enolization-reprotonation. Copyright (C) 1999 Elsevier Science Ltd.
Highly efficient and scalable synthesis of clionamine D
Wang, Sha-Sha,Shi, Yong,Tian, Wei-Sheng
supporting information, p. 2177 - 2179 (2014/05/06)
Herein we describe an efficient and scalable synthesis of clionamine D (4), a special member with autophagy bioactivity and an unprecedented spirobislactone side chain in the novel aminosteroid clionamines. This synthesis features a quick access to α-methylene-γ-lactone 8 and a Mn(OAc)3-mediated radical [3 + 2] reaction to assemble the unique spirobislactone unit. Clionamine D (4) can also serve as a key synthetic precursor to other clionamine members.