51044-11-2

Basic information

• Product Name: (4-FLUOROBENZYL)TRIPHENYLPHOSPHONIUM BROMIDE
• Synonyms: (4-FLUOROBENZYL)TRIPHENYLPHOSPHONIUM BROMIDE;(4-FLUOROBENZYL)TRIPHENYLPHOSP
• CAS NO: 51044-11-2
• Molecular Formula: C25H21BrFP
• Molecular Weight: 451.31
• Mol File: 51044-11-2.mol
• Article Data: 23

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (4-FLUOROBENZYL)TRIPHENYLPHOSPHONIUM BROMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: (4-FLUOROBENZYL)TRIPHENYLPHOSPHONIUM BROMIDE(51044-11-2)
• EPA Substance Registry System: (4-FLUOROBENZYL)TRIPHENYLPHOSPHONIUM BROMIDE(51044-11-2)

Safety Data

• Hazardous Substances Data: 51044-11-2(Hazardous Substances Data)

Usage

General Description

(4-Fluorobenzyl)triphenylphosphonium bromide is a chemical compound with the molecular formula C27H22BrP. It is a phosphonium salt that is commonly used as a phase-transfer catalyst in organic synthesis. (4-FLUOROBENZYL)TRIPHENYLPHOSPHONIUM BROMIDE is a white solid at room temperature and is highly soluble in polar solvents such as water and methanol. It is most commonly used in the preparation of a variety of organic compounds by facilitating the transfer of substrates between two immiscible phases, such as between an aqueous and organic phase. It is also used as a reagent in various chemical reactions and has applications in both academic and industrial research.

InChI:InChI=1/C25H21FP.BrH/c26-22-18-16-21(17-19-22)20-27(23-10-4-1-5-11-23,24-12-6-2-7-13-24)25-14-8-3-9-15-25;/h1-19H,20H2;1H/q+1;/p-1

Upstream product

• 459-56-3 4-fluorobenzylic alcohol 
• 6399-81-1 triphenylphosphine hydrobromide 
• 459-57-4 4-fluorobenzaldehyde 
• 352-32-9 p-fluorotoluene 
• 603-35-0 triphenylphosphine 
• 459-46-1 4-Fluorobenzyl bromide 

Downstream Products

• 141544-88-9 (E,E)-1-(4-fluorophenyl)-4-(4-hexyloxyphenyl)buta-1,3-diene 
• 147425-11-4 1-Bromo-2,4,5-trifluoro-3-[(E)-2-(4-fluoro-phenyl)-vinyl]-benzene 
• 41529-11-7 6-fluoro-2-(4-fluorophenyl)-1H-indole 

Relevant articles and documents

Coupling Photocatalysis and Substitution Chemistry to Expand and Normalize Redox-Active Halides

Photocatalysis can generate radicals in a controlled fashion and has become an important synthetic strategy. However, limitations due to the reducibility of alkyl halides prevent their broader implementation. Herein we explore the use of nucleophiles that can substitute the halide and serve as an electron capture motif that normalize the variable redox potentials across substrates. When used with photocatalysis, bench-stable, commercially available collidinium salts prove to be excellent radical precursors with a broad scope.

Anti-oligomerization sheet molecules: Design, synthesis and evaluation of inhibitory activities against α-synuclein aggregation

Aggregation of α-synuclein (α-Syn) play a key role in the development of Parkinson Disease (PD). One of the effective approaches is to stabilize the native, monomeric protein with suitable molecule ligands. We have designed and synthesized a series of sheet-like conjugated compounds which possess different skeletons and various heteroatoms in the two blocks located at both ends of linker, which have good π-electron delocalization and high ability of hydrogen-bond formation. They have shown anti-aggregation activities in vitro towards α-Syn with IC50 down to 1.09 μM. The molecule is found binding in parallel to the NACore within NAC domain of α-Syn, interfering aggregation of NAC region within different α-Syn monomer, and further inhibiting or slowing down the formation of α-Syn oligomer nuclei at lag phase. The potential inhibitor obtained by our strategy is considered to be highly efficient to inhibit α-Syn aggregation.

One-Step Synthesis of Substituted Benzofurans from ortho- Alkenylphenols via Palladium-Catalyzed C=H Functionalization

A dehydrogenative oxygenation of C(sp2)=H bonds with intramolecular phenolic hydroxy groups has been developed, which provides a straightforward and concise access to structurally diversely benzofurans from ortho-alkenylphenols. The reaction is catalyzed by palladium on carbon (Pd/C) without any oxidants and sacrificing hydrogen acceptors.