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50730-05-7

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50730-05-7 Usage

Description

4'-Chlorophenyl-2-acetamido-2-deoxy-beta-D-glucopyranoside is a complex chemical compound with a molecular formula C16H21ClN2O7. It is a beta-D-glucopyranoside derivative that contains a 4'-chlorophenyl group and an acetamido group. 4'-CHLOROPHENYL-2-ACETAMIDO-2-DEOXY-BETA-D-GLUCOPYRANOSIDE is often used as a substrate in enzymatic reactions for the study of glycosyltransferases and other carbohydrate-modifying enzymes. It may also have potential applications in pharmaceutical research, particularly in the development of new drugs targeting carbohydrate metabolism or glycosylation processes. Additionally, its unique structure and properties make it a valuable tool for studying the structure-function relationships of carbohydrates and glycosides.

Uses

Used in Pharmaceutical Research:
4'-Chlorophenyl-2-acetamido-2-deoxy-beta-D-glucopyranoside is used as a substrate in enzymatic reactions for the study of glycosyltransferases and other carbohydrate-modifying enzymes. Its unique structure and properties make it a valuable tool for studying the structure-function relationships of carbohydrates and glycosides, which can contribute to the development of new drugs targeting carbohydrate metabolism or glycosylation processes.
Used in Biochemical Research:
In the field of biochemical research, 4'-chlorophenyl-2-acetamido-2-deoxy-beta-D-glucopyranoside is used as a substrate to investigate the mechanisms of enzymatic reactions involving glycosyltransferases. Understanding these mechanisms can provide insights into the regulation of carbohydrate metabolism and the role of glycosylation in various biological processes.
Used in Drug Development:
4'-Chlorophenyl-2-acetamido-2-deoxy-beta-D-glucopyranoside may have potential applications in the development of new drugs targeting carbohydrate metabolism or glycosylation processes. Its unique structure and properties can be leveraged to design and synthesize novel compounds with therapeutic potential in treating diseases related to carbohydrate metabolism or glycosylation abnormalities.
Used in Analytical Chemistry:
In analytical chemistry, 4'-chlorophenyl-2-acetamido-2-deoxy-beta-D-glucopyranoside can be used as a reference compound for the development and validation of analytical methods for the detection and quantification of similar compounds in complex biological samples. Its unique structure and properties can help in the optimization of chromatographic, spectroscopic, or mass spectrometric techniques for the analysis of carbohydrates and their derivatives.

Check Digit Verification of cas no

The CAS Registry Mumber 50730-05-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,0,7,3 and 0 respectively; the second part has 2 digits, 0 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 50730-05:
(7*5)+(6*0)+(5*7)+(4*3)+(3*0)+(2*0)+(1*5)=87
87 % 10 = 7
So 50730-05-7 is a valid CAS Registry Number.

50730-05-7Downstream Products

50730-05-7Relevant articles and documents

Probing synergy between two catalytic strategies in the glycoside hydrolase O-GlcNAcase using multiple linear free energy relationships

Greig, Ian R.,Macauley, Matthew S.,Williams, Ian H.,Vocadlo, David J.

supporting information; experimental part, p. 13415 - 13422 (2010/01/16)

Human O-GlcNAcase plays an important role in regulating the post-translational modification of serine and threonine residues with β-O-linked N-acetylglucosamine monosaccharide unit (O-GlcNAc). The mechanism of O-GlcNAcase involves nucleophilic participation of the 2-acetamido group of the substrate to displace a glycosidically linked leaving group. The tolerance of this enzyme for variation in substrate structure has enabled us to characterize O-GlcNAcase transition states using several series of substrates to generate multiple simultaneous free-energy relationships. Patterns revealing changes in mechanism, transition state, and rate-determining step upon concomitant variation of both nucleophilic strength and leaving group abilities are observed. The observed changes in mechanism reflect the roles played by the enzymic general acid and the catalytic nucleophile. Significantly, these results illustrate how the enzyme synergistically harnesses both modes of catalysis; a feature that eludes many small molecule models of catalysis. These studies also suggest the kinetic significance of an oxocarbenium ion intermediate in the O-GlcNAcase-catalyzed hydrolysis of glucosaminides, probing the limits of what may be learned using nonatomistic investigations of enzymic transition-state structure and offering general insights into how the superfamily of retaining glycoside hydrolases act as efficient catalysts.

Carbohydrate protein interactions. Syntheses of agglutination inhibitors of wheat germ agglutinin by phase transfer catalysis

Roy, Rene,Tropper, Francois D.

, p. 817 - 821 (2007/10/02)

Starting from chloride 1, a series of para-substituted aryl 2-acetamido-2-deoxy-β-D-glucopyranosides were prepared using phase transfer catalysis conditions with tetrabutylammonium hydrogen sulfate in 1 M sodium hydroxide and methylene chloride at room temperature.Zemplen de-O-acetylation afforded the unprotected glycosides.Optimization of reaction conditions was evaluated.Several functional group manipulations were effected to widen the number and nature of the para-substituents. Key words: phase transfer catalysis, aryl 2-acetamido-2-deoxy-β-D-glucopyranosides.

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