50638-49-8

Basic information

• Product Name: 4-Bromo-2,N,N-trimethylaniline
• Synonyms: 4-Bromo-2,N,N-trimethylaniline;1-Bromo-4-(dimethylamino)-3-methylbenzene;BenzenaMine, 4-broMo-N,N,2-triMethyl-;(4-Bromo-2-methyl-phenyl)-dimethyl-amine
• CAS NO: 50638-49-8
• Molecular Formula: C₉H₁₂BrN
• Molecular Weight: 214.10228
• Product Categories: Amino;Aryl;Organohalides
• Mol File: 50638-49-8.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 4-Bromo-2,N,N-trimethylaniline(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Bromo-2,N,N-trimethylaniline(50638-49-8)
• EPA Substance Registry System: 4-Bromo-2,N,N-trimethylaniline(50638-49-8)

Safety Data

• Hazardous Substances Data: 50638-49-8(Hazardous Substances Data)

Usage

Description

4-Bromo-2,N,N-trimethylaniline is a chemical compound belonging to the aniline and substituted aniline family, characterized by its molecular formula C9H12BrN. It features an aniline group (a phenyl group attached to an amino group) that has been substituted with three methyl groups and a bromine atom. The presence of the bromine atom suggests that this compound may be involved in coupling reactions, where two hydrocarbon fragments are joined together. As with other anilines, it requires careful handling due to potential harmful or toxic properties.

Uses

Used in Pharmaceutical Industry:
4-Bromo-2,N,N-trimethylaniline is used as an intermediate compound for the synthesis of various drugs. Its unique structure allows it to be a key component in the development of new pharmaceuticals, contributing to the creation of novel therapeutic agents.
Used in Dye Production:
4-Bromo-2,N,N-trimethylaniline is used as a precursor in the production of dyes. Its chemical properties make it suitable for the synthesis of a range of dyes, which can be used in various industries such as textiles, plastics, and printing.
Used in Plastics Industry:
4-Bromo-2,N,N-trimethylaniline is used as a monomer in the production of certain types of plastics. Its chemical structure can be polymerized to form plastics with specific properties, such as improved strength or resistance to certain conditions, making it a valuable component in the development of new materials.
Used in Chemical Research:
4-Bromo-2,N,N-trimethylaniline is used as a research compound in various chemical studies. Its unique structure and reactivity make it an interesting subject for investigation, potentially leading to new discoveries and applications in the field of chemistry.

Upstream product

• 67-66-3 chloroform 
• 609-72-3 N,N-dimethyl-o-toluidine 
• 67-64-1 acetone 
• 7726-95-6 bromine 
• 64-19-7 acetic acid 
• 50-00-0 formaldehyd 
• 583-75-5 4-Bromo-2-methylaniline 
• 6852-47-7 N,N-dimethyl-N-(2'-methylphenyl)amine N-oxide 
• 74-88-4 methyl iodide 
• 64230-27-9 2,4-dibromo-N,N-dimethylaniline 
• 7732-18-5 water 
• 7647-01-0 hydrogenchloride 
• 30273-41-7 2,4-dibromo-6-methylaniline 
• 512-56-1 trimethyl phosphite 

Downstream Products

• 3564-94-1 N⁴,N⁴,N^4',N^4',3,3'-hexamethyl-[1,1'-biphenyl]-4,4'-diamine 
• 1613259-64-5 N,N,2-trimethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline 
• 27751-12-8 2,N,N,N',N'-pentamethyl-p-phenylenediamine 
• 99768-14-6 N-(4-bromo-2-methylphenyl)-N-methylnitrous amide 
• 1070716-56-1 2-[4-(dimethylamino)-3-methylphenyl]hexanal 
• 1070716-58-3 4-(benzyloxy)-2-[4-(dimethylamino)-3-methylphenyl]butanal 
• 106269-97-0 4-dimethylamino-3-methyl-benzoic acid ethyl ester 
• 96818-62-1 bis(n-butylsulfenyl)(N,N-dimethylamino)methylbenzene 
• 96818-61-0 (4,5-Dibromo-2-methyl-phenyl)-dimethyl-amine 
• 103030-89-3 4-(N,N-dimethylamino)-3-methylbenzoic acid 

Relevant articles and documents

Novel monoacylglycerol lipase inhibitor as well as preparation method and application thereof

The invention discloses a novel monoacylglycerol lipase inhibitor as well as a preparation method and application thereof. Specifically, the invention provides a compound shown as a formula I, or a pharmaceutically acceptable salt, a stereoisomer, or a deuterated derivative thereof. Experimental results show that the compound provided by the invention can effectively inhibit MAGL activity, can beused for preparing an MAGL inhibitor and preparing medicines for preventing and/or treating diseases (including endometrial cancer, colorectal cancer, liver cancer, breast cancer, ovarian cancer, neurodegenerative diseases and the like) related to abnormal MAGL activity, and has a wide application prospect.

Synthesis of Halogenated Anilines by Treatment of N, N-Dialkylaniline N-Oxides with Thionyl Halides

The special reactivity of N,N-dialkylaniline N-oxides allows practical and convenient access to electron-rich aryl halides. A complementary pair of reaction protocols allow for the selective para-bromination or ortho-chlorination of N,N-dialkylanilines in up to 69% isolated yield. The generation of a diverse array of halogenated anilines is made possible by a temporary oxidation level increase of N,N-dialkylanilines to the corresponding N,N-dialkylaniline N-oxides and the excision of the resultant weak N-O bond via treatment with thionyl bromide or thionyl chloride at low temperature.

SUBSTITUTED PYRIDOPYRAZINES AS SYK INHIBITORS

The present invention relates to pyridopyrazine compounds of formula (I), pharmaceutical compositions thereof and methods of use therefore, wherein R1, R2, R3, L, m, p and W are as defined in the specification.