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50622-09-8

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50622-09-8 Usage

Description

(+)-2,3-O-Isopropylidene-L-threitol is a significant organic compound characterized by its white transparent, adhering, needle-like crystalline structure. It serves as a crucial raw material and intermediate in various industries due to its unique chemical properties and reactivity.

Uses

Used in Organic Synthesis:
(+)-2,3-O-Isopropylidene-L-threitol is used as a key intermediate for the synthesis of various organic compounds. Its unique structure allows it to participate in a range of chemical reactions, making it a valuable component in the creation of new molecules and materials.
Used in Pharmaceuticals:
In the pharmaceutical industry, (+)-2,3-O-Isopropylidene-L-threitol is utilized as a vital building block for the development of new drugs. Its chemical properties enable it to be incorporated into the structures of various medicinal compounds, potentially leading to the discovery of novel therapeutic agents.
Used in Agrochemicals:
(+)-2,3-O-Isopropylidene-L-threitol is employed as a crucial component in the production of agrochemicals, such as pesticides and fertilizers. Its chemical properties make it suitable for use in the development of these products, which are essential for maintaining agricultural productivity and crop protection.
Used in Dyestuff:
In the dyestuff industry, (+)-2,3-O-Isopropylidene-L-threitol is used as an important intermediate for the synthesis of various dyes and pigments. Its unique chemical structure allows it to contribute to the creation of a wide range of colors and shades, enhancing the diversity of dyes available for various applications.

Check Digit Verification of cas no

The CAS Registry Mumber 50622-09-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,0,6,2 and 2 respectively; the second part has 2 digits, 0 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 50622-09:
(7*5)+(6*0)+(5*6)+(4*2)+(3*2)+(2*0)+(1*9)=88
88 % 10 = 8
So 50622-09-8 is a valid CAS Registry Number.
InChI:InChI=1/C7H14O4/c1-7(2)10-5(3-8)6(4-9)11-7/h5-6,8-9H,3-4H2,1-2H3/t5-,6-/m0/s1

50622-09-8 Well-known Company Product Price

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  • TCI America

  • (I0376)  (+)-2,3-O-Isopropylidene-L-threitol  >97.0%(GC)

  • 50622-09-8

  • 1g

  • 510.00CNY

  • Detail
  • TCI America

  • (I0376)  (+)-2,3-O-Isopropylidene-L-threitol  >97.0%(GC)

  • 50622-09-8

  • 5g

  • 1,560.00CNY

  • Detail
  • Alfa Aesar

  • (B23090)  (+)-2,3-O-Isopropylidene-L-threitol, 98%   

  • 50622-09-8

  • 1g

  • 651.0CNY

  • Detail
  • Alfa Aesar

  • (B23090)  (+)-2,3-O-Isopropylidene-L-threitol, 98%   

  • 50622-09-8

  • 5g

  • 1610.0CNY

  • Detail
  • Aldrich

  • (59539)  (4S,5S)-2,2-Dimethyl-1,3-dioxolane-4,5-dimethanol  ≥97.0% (sum of enantiomers, GC)

  • 50622-09-8

  • 59539-5G

  • 1,263.60CNY

  • Detail

50622-09-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name (4S,5S)-(+)-4,5-Bis(hydroxymethyl)-2,2-dimethyl-1,3-dioxolane

1.2 Other means of identification

Product number -
Other names (4S,5S)-(+)-2,2-Dimethyl-1,3-dioxolane-4,5-dimethanol

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:50622-09-8 SDS

50622-09-8Relevant articles and documents

Supramolecular gels from sugar-linked triazole amphiphiles for drug entrapment and release for topical application

Sharma, Komal,Joseph, Jojo P.,Sahu, Adarsh,Yadav, Narender,Tyagi, Mohit,Singh, Ashmeet,Pal, Asish,Kartha, K.P. Ravindranathan

, p. 19819 - 19827 (2019)

A simple molecular framework obtained by cross-linking a hydrophobic chain with S,S- and R,R-tetritol by the copper-catalysed azide-alkyne cycloaddition reaction is found to serve as an excellent bioisostere for self-assembly. The hexadecyl-linked triazolyl tetritol composite spontaneously self-assembles in n-hepane and methanol to form hierarchical organogels. Microscopic analyses and X-ray diffraction studies demonstrate eventual formation of nanotubes through lamellar assembly of the amphiphiles. A rheological investigation shows solvent-dictated mechanical properties that obey power law behavior similar to other low molecular weight gelators (LMOGs). The gel network was then utilized for the entrapment of drugs e.g. ibuprofen and 5-fluorouracil, with tunable mechanical behaviour under applied stress. The differential release profiles of the drugs over a period of a few hours as a result of the relative spatio-temporal location in the supramolecular network can be utilized for topical formulations.

Concise approach to the "higher sugar" core of the nucleoside antibiotic hikizimycin

Fuerstner, Alois,Wuchrer, Margarita

, p. 76 - 89 (2006)

A highly productive synthesis of phenylthio glycoside 33 is described which constitutes a fully functional surrogate for the hikosamine core of hikizimycin 1, a complex nucleoside antibiotic endowed with promising anthelmintic properties. The chosen approach to this undecose derivative starts from mannofuranose 7 which was one-carbon homologated to alkyne 8 in one step on treatment with lithio (trimethylsilyl)diazomethane. Alkynyl iodide 12 derived from 8 was combined with the tartrate-derived aldehyde 17 by a Nozaki-Hiyama-Kishi reaction that can either be performed using overstoichiometric amounts of CrCl2 or by means of a catalytic manifold based on the turnover of a cat. CrCl2/chlorosilane/manganese redox couple. Semi-hydrogenation of the resulting alkyne 18 to (Z)-olefin 19 required the use of Pd/ C as the catalyst, whereas conventional Lindlar reduction was unsatisfactory. Attempted cis-dihydroxylation of alkene 22 (formed from 19 by a Mitsunobu reaction with phthalimide) by using catalytic amounts of OsO4 and NMO as the stoichiometric oxidant essentially failed, whereas a stoichiometric osmylation afforded the stable osmate ester 26 a as a single diastereomer. Since the use of OsO4 in stoichiometric amounts deemed inappropriate for a total synthesis project, recourse was taken to catalytic "Blitz dihydroxylation" with RuO4 in the presence of FeCl2·4 H2O as co-catalyst. Application of these conditions to alkene 30 bearing a free aldehyde function at the terminus of the "higher sugar" chain furnished pyranose 32 in good yield and excellent diastereoselectivity, which was converted into the targeted thioglycoside 33 on treatment with PhSSPh/Et3P. It is particularly noteworthy that the conformational constraints of the acyclic substrate 30 enforce the dihydroxylation to violate Kishi's empirical rule for transformations of this type.

Synthesis of diacylglycerol analogs bearing photoaffinity tags for labelling mammalian diacylglycerol kinase

Eni, Sammy Eni,Rowland, Meng,Best, Michael D.

, p. 25457 - 25461 (2015)

Signaling lipids such as diacylglycerol (DAG), phosphatidic acid, and the phosphatidylinositol polyphosphates are site-specific ligands for protein binding partners. Herein, we report the apotheoses of our initial approach to the development of diverse probes which are vital for understanding lipid-protein interactions. When incorporated into liposomes, these probes reduce mammalian diacylglycerol kinase's (DGK) enzymatic activity in a concentration, time, and light dependent manner. This journal is

Concise synthesis of: N -phosphorylated amides through three-component reactions

Yang, Shang-Dong,Zhang, Tao,Zhou, Linlin,Zhu, Yuan-Yuan

supporting information, p. 9417 - 9421 (2021/12/09)

N-Phosphorylated amides continue to be an unparalleled asset for the development of pharmaceutical molecules, and the importance of this framework has inspired researchers to look for concise and efficient methods for the synthesis of this unit. In this work, a new strategy was developed in which a one-pot synthesis of N-phosphorylated amides was achieved by a three-component reaction with carboxylic acids, phosphorus chlorides and azides under mild reaction conditions. To our knowledge, this is the first study in which this framework was constructed through a multicomponent reaction, which is innovative, efficient and economical. This journal is

A Synthesis Strategy for the Production of a Macrolactone of Gulmirecin A via a Ni(0)-Mediated Reductive Cyclization Reaction

Ichikawa, Satoshi,Katsuyama, Akira,Kitahata, Shun

supporting information, (2020/03/30)

A synthesis strategy for the production of a key synthetic intermediate of gulmirecin A was described. The key reaction in the preparation of the 12-membered macrolactone is the Ni(0)-mediated reductive cyclization reaction of ynal using an N-heterocyclic carbene ligand and silane reductant. In addition, the α-selective glycosylation reaction of the macrolactone was performed to demonstrate the synthesis of gulmirecin and disciformycin precursors.

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