5049-61-6Relevant articles and documents
Green Synthesis and Antimicrobial Activity of Some Novel N-Arylimidazo[1,2-a]pyrazine-2-Carboxamide Derivatives
Jyothi, Boggavarapu,Madhavi, Nannapaneni
, p. 84 - 90 (2020)
The article deals with the synthesis of some novel N-arylimidazo[1,2-a]pyrazine-2-carboxamides (7a-l) by condensation reaction of imidazo[1,2-a]pyrazine-2-carboxylic acid (5) with different aliphatic/aromatic amines (6a-l) by using 1-methylimidazole, Mukaiyama’s reagent and 2-chloro-1-methylpyridinium iodide under microwave irradiation conditions. A new series of compounds 7 have been prepared from 2-iodopyrazine (1). Compound 1 on purged with ammonia gas in the presence of Cu2O and K2CO3 furnishes pyrazin-2-amine (2), which is treated with ethyl 3-bromo-2-oxopropanoate (3) to produce ethyl imidazo[1,2-a]pyrazine-2-carboxylate (4), which on hydrolysis with NaOH yields imidazo[1,2-a]pyrazine-2-carboxylic acid (5). The structures of the newly synthesized compounds have been elucidated on the basis of spectral (IR, 1H and 13C NMR and MS) and analytical data. Compounds 7a-l have also been screened for their antimicrobial activity. Some of the compounds exhibit promising antimicrobial activity.
Novel method for synthesizing 2- amino -3,5- dibromopyrazine as well as product and application thereof
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Paragraph 0042; 0060-0061; 0066; 0071; 0077; 0078, (2020/03/25)
The invention discloses a novel method 2 - for synthesizing, amino - 333355-dibromopyrazine by reacting, with,aminopyrazine 2 - sodium hypochlorite as a raw material, and adding, amino-pyrazino,dibromopyrazine 2 - in ;amino - 3333,5-dibromopyrazine as a raw material by, hours N,N - to obtain,aminopypyrazine 1,3 - in step, as a solvent 2 - and dropping under reduced pressure. N,N - The present invention provides a novel method for synthesizing, amino-3,5-dibromopyrazine as a crude product 15 - 20 in a reduced pressure distillation condition . The present invention. discloses a process 2 - for the preparation of the product. 2 - The present invention discloses 2 - N - 3333,5-dibromopyrazino, crude, obtained by the present, invention is added dropwise to prepare 2 - lamino - 3333.5-dibromopyrazine.
Copper-catalyzed arene amination in pure aqueous ammonia
Takagi, Mio,Watanabe, Ayako,Murata, Shigeo,Takita, Ryo
supporting information, p. 1791 - 1795 (2019/02/20)
A simple protocol for copper-catalyzed arene amination using aqueous ammonia without any additional ligands and organic coordinating solvents has been developed. The reaction pathway via a Cu(i)/Cu(iii) mechanism is proposed based on the results of control experiments as well as DFT calculations.