503468-95-9 Usage
Description
KU57788 (NU7441) is a potent and selective DNA-dependent protein kinase (DNA-PK) inhibitor with an IC50 value of 14 nM. It is a novel compound that has been developed as an antitumor agent, specifically targeting DNA-PK, which plays a crucial role in the repair of lethal DNA double-strand breaks. By inhibiting DNA-PK, KU57788 (NU7441) can potentially enhance the sensitivity of cancer cells to radiation or chemotherapeutic treatments.
Uses
Used in Anticancer Applications:
KU57788 (NU7441) is used as an antitumor agent for its ability to inhibit DNA-PK, a key enzyme involved in the repair of DNA double-strand breaks. This inhibition can lead to increased sensitivity of cancer cells to radiation and chemotherapeutic treatments, making it a promising candidate for cancer therapy.
Used in Drug Delivery Systems:
KU57788 (NU7441) is used as a component in drug delivery systems to improve the delivery, bioavailability, and therapeutic outcomes of cancer treatments. By incorporating this potent DNA-PK inhibitor into various organic and metallic nanoparticles, researchers aim to enhance the efficacy of cancer treatments and overcome limitations associated with traditional drug delivery methods.
Used in Pharmaceutical Research:
KU57788 (NU7441) is used as a potent and selective DNA-PK inhibitor in the development of novel cancer treatment strategies. Its ability to inhibit DNA-PK and other members of the PI3K-related kinase family, such as mTOR, PI3K, ATM, and ATR, makes it a valuable tool for researchers in the field of oncology.
Used in Cancer Cell Research:
KU57788 (NU7441) is used as a research tool in the study of cancer cell biology, particularly in the context of DNA double-strand break repair and the role of DNA-PK in this process. By understanding the effects of this inhibitor on cancer cells, researchers can gain insights into the development of more effective cancer treatments.
Used in Preclinical Cancer Models:
KU57788 (NU7441) is used in preclinical cancer models to evaluate its potential as a therapeutic agent. By testing its efficacy in human colon cancer cell lines and mice bearing human colon cancer xenograft tumors, researchers can assess the compound's ability to potentiate the effects of etoposide and other chemotherapeutic agents in vivo.
References
1) Leahy?et al.?(2004),?Identification of a highly potent and selective DNA-dependent protein kinase (DNA-PK) inhibitor (NU7441) by screening of chromenone libraries; Bioorg. Med. Chem. Lett.,?14?6083
2) Hardcastle?et al.?(2005),?Discovery of potent chromen-4-one inhibitors of the DNA-dependent protein kinase (DNA-PK) using a small-molecule library approach: J. Med. Chem.,?48?7829
3) Zhao?et al.?(2006),?Preclinical evaluation of a potent novel DNA-dependent protein kinase inhibitor NU7441: Cancer Res.?66?5354
4) Ciszewski?et al.?(2014),?DNA-PK inhibition by NU7441 sensitizes breast cancer cells to ionizing radiation and doxorubicin: Breast Cancer Res. Treat.,?143?83
5) Yang?et al.?(2016),?NU7441 Enhances the Radiosensitivity of Liver Cancer Cells: Cell Physiol. Biochem.,?38?1897
6) Geng?et al.?(2019),?DNA-PKcs inhibitor increases the sensitivity of gastric cancer cells to radiotherapy: Oncol. Rep.,?42?561
Check Digit Verification of cas no
The CAS Registry Mumber 503468-95-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 5,0,3,4,6 and 8 respectively; the second part has 2 digits, 9 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 503468-95:
(8*5)+(7*0)+(6*3)+(5*4)+(4*6)+(3*8)+(2*9)+(1*5)=149
149 % 10 = 9
So 503468-95-9 is a valid CAS Registry Number.
InChI:InChI=1/C25H19NO3S/c27-21-15-23(26-11-13-28-14-12-26)29-24-17(6-3-9-20(21)24)19-8-4-7-18-16-5-1-2-10-22(16)30-25(18)19/h1-10,15H,11-14H2
