500288-66-4

Basic information

• Product Name: 2-Propenamide, 3-[4-[[2-[(4-cyanophenyl)amino]-4-pyrimidinyl]amino]-3,5-dimethylphenyl ]-, (2E)-
• CAS NO: 500288-66-4
• Molecular Formula: C22H20N6O
• Molecular Weight: 384.44
• Mol File: 500288-66-4.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2-Propenamide, 3-[4-[[2-[(4-cyanophenyl)amino]-4-pyrimidinyl]amino]-3,5-dimethylphenyl ]-, (2E)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Propenamide, 3-[4-[[2-[(4-cyanophenyl)amino]-4-pyrimidinyl]amino]-3,5-dimethylphenyl ]-, (2E)-(500288-66-4)
• EPA Substance Registry System: 2-Propenamide, 3-[4-[[2-[(4-cyanophenyl)amino]-4-pyrimidinyl]amino]-3,5-dimethylphenyl ]-, (2E)-(500288-66-4)

Safety Data

• Hazardous Substances Data: 500288-66-4(Hazardous Substances Data)

Usage

Type of Compound

Propenamide

Chemical Structure

Contains a carbon-carbon double bond and an amide functional group

Functional Groups

Aromatic rings
Amino groups

Configuration

(2E) designation indicates cis configuration with respect to the double bond

Potential Applications

Chemical synthesis
Pharmaceutical applications

Interest for Further Study

Unique arrangement and functional groups make it suitable for research and potential applications in various fields

Upstream product

• 24596-19-8 4-bromo-2,6-dimethylphenylamine 
• 244768-32-9 4-[(4-chloro-2-pyrimidinyl)amino]benzonitrile 
• 79-06-1 2-propenamide 
• 374067-85-3 4-((4-((4-bromo-2,6-dimethylphenyl)amino)pyrimidin-2-yl)amino)benzonitrile 

Downstream Products

• 500287-72-9 rilpivirine 

Relevant articles and documents

Method for preparing high-purity ribavirin intermediate by one-pot method (by machine translation)

The invention relates to the technical field of chemical medicine, in particular to a method for preparing a high-purity ribavirin intermediate by a one-pot method. The method comprises the following steps: (1) replacing the compound I with the compound II to obtain the reaction liquid of the compound III. (2) Acrylamide was added to III reaction liquid of the compound, and the reaction liquid of compound IV was obtained under Heck reaction conditions. (3) In the reaction solution of Compound IV, activated carbon is first added for decolorization treatment, and then a poor solvent is added for crystallization to obtain a white compound IV, i.e. a ripe intermediate. The method for preparing the high-purity ribavirin intermediate by one-pot method is scientific, reasonable, simple and feasible, improves product purity and yield, and is suitable for large-scale production. (by machine translation)

PROCESSES FOR THE PREPARATION OF 4-[[4-[[4-(2-CYANOETHENYL)-2,6-DIMETHYLPHENYL]AMINO]-2-PYRIMIDINYL]AMINO]BENZONITRILE

Processes for the preparation of 4-[[4-[[4-(2-cyanoethenyl)-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino]benzonitrile of formula (I), a N-oxide, a pharmaceutically acceptable acid addition salt, a quaternary amine or a stereochemically isomeric form thereof are provided, said processes comprise a) reacting 4-(2-cyanoethenyl)-2,6-dimethylbenzenamine with an intermediate of formula (III) in the presence of a suitable solvent; b) reacting an intermediate of formula (IV) with acrylonitrile in the presence of a suitable palladium catalyst, a suitable base and a suitable solvent; c) dehydrating the corresponding amide of the compound of formula (I).