49791-37-9

Basic information

• Product Name: OXO-PYRROLIDIN-1-YL-ACETIC ACID
• Synonyms: OXO-PYRROLIDIN-1-YL-ACETIC ACID;OTAVA-BB 1129780;OXO(1-PYRROLIDINYL)ACETIC ACID;oxo(1-pyrrolidinyl)acetic acid(SALTDATA: FREE);2-keto-2-pyrrolidin-1-yl-acetic acid;2-oxo-2-1-pyrrolidinylacetic acid;2-oxo-2-pyrrolidin-1-ylacetic acid;2-oxo-2-pyrrolidin-1-yl-acetic acid
• CAS NO: 49791-37-9
• Molecular Formula: C6H9NO3
• Molecular Weight: 143.14
• Mol File: 49791-37-9.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 281.8°C at 760 mmHg
• Flash Point: 124.3°C
• Appearance: /
• Density: 1.354g/cm³
• Vapor Pressure: 0.000916mmHg at 25°C
• Refractive Index: 1.532
• PKA: 1.97±0.54(Predicted)
• CAS DataBase Reference: OXO-PYRROLIDIN-1-YL-ACETIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: OXO-PYRROLIDIN-1-YL-ACETIC ACID(49791-37-9)
• EPA Substance Registry System: OXO-PYRROLIDIN-1-YL-ACETIC ACID(49791-37-9)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 49791-37-9(Hazardous Substances Data)

Usage

General Description

OXO-PYRROLIDIN-1-YL-ACETIC ACID, also known as Oxiracetam, is a chemical compound that is often used as a nootropic, a type of drug that enhances cognitive function. It is a derivative of the neurotransmitter gamma-aminobutyric acid (GABA) and is believed to improve memory, learning, and focus. Oxiracetam has been studied for its potential to treat cognitive impairment and dementia, as well as its ability to enhance cognitive performance in healthy individuals. It is also thought to have neuroprotective properties and may help protect the brain from damage caused by various toxins and injuries. While the exact mechanisms of action are not fully understood, Oxiracetam is believed to work by modulating the release of certain neurotransmitters in the brain, such as acetylcholine and glutamate, which are important for cognitive function. Overall, Oxiracetam has shown promise as a cognitive enhancer and neuroprotective agent, although more research is needed to fully understand its potential benefits and risks.

InChI:InChI=1/C6H9NO3/c8-5(6(9)10)7-3-1-2-4-7/h1-4H2,(H,9,10)

Upstream product

• 123-75-1 pyrrolidine 
• 17118-74-0 ethyl oxalylchloride 
• 41600-21-9 methyl 2-oxo-2-(pyrrolidin-1-yl)acetate 
• 41600-22-0 Ethyl-α-oxopyrrolidin-1-acetat 

Relevant articles and documents

Direct C-H Functionalization of Phenanthrolines: Metal- And Light-Free Dicarbamoylations

A direct method for C-H dicarbamoylations of phenanthrolines has been developed, which is capable of directly installing primary, secondary as well as tertiary amides. This is a significant improvement on the previous direct method, which was limited to primary amides. The metal-, light-, and catalyst-free Minisci-type reaction is cheap, operationally simple, and scalable. We demonstrate that the step efficiency toward dicarbamoylated phenanthroline targets can now be significantly improved.

DOPAMINE D3 RECEPTOR ANTAGONISTS HAVING A BICYCLO MOIETY

The disclosure provides compounds having formula (I), wherein the substituents are as defined herein. The compounds are useful for modulating the dopamine D3 receptor and for treating conditions associated therewith, such as addictions, drug dependency, and psychiatric conditions.

Design, synthesis, structure, and acaricidal/insecticidal activity of novel spirocyclic tetronic acid derivatives containing an oxalyl moiety

A series of novel spirocyclic tetronic acid derivatives containing an oxalyl moiety was designed and synthesized via the key intermediate 3-(2,4,6-trimethyl)-2-oxo-1-oxaspiro[4.4]-decyl-3-en-4-ol. The target compounds were identified by 1H NMR and elemental analysis or high-resolution mass spectrum (HRMS). The results of bioassays indicated that most of the target compounds possessed excellent acaricidal activities against carmine spider mite larvae and eggs. Especially, diisopropylamino oxalyl compound 7g and piperidine oxalyl compound 7h were 1.4- and 2.3-fold as high as the activities of commercial Spiromesifen, respectively, against spider mite eggs. Moreover, most of the target compounds exhibited insecticidal activities against Lepidoptera pest. Interestingly, compounds containing alkylamino-substituted oxalyl moiety showed obvious selectivity between spider mite larvae and eggs because the activities against spider mite eggs of 7g and 7h were 25-fold those against spider mite larvae, whereas Spiromesifen had no significant differences in these activities. This meant that the introduction of an oxalyl moiety to spirocyclic tetronic acid might lead to novel biological activity characteristics.