482-44-0 Usage
Description
Imperatorin, a furocoumarin and phytochemical, is found in citrus fruits and can be isolated from Urena lobata L. (Malvaceae). It is biosynthesized from Umbelliferae in vivo and has been identified for its anti-hypertrophic and anti-convulsant effects. Imperatorin is also useful in HIV-1 research, as it requires the transcription factor Sp1 to exert its inhibitory effect on the virus. It can inhibit the expression of cyclin D1, causing cell cycle arrest at the G1 stage, and suppress HIV-1 replication in primary T lymphocytes and transformed cell lines. Additionally, Imperatorin has been shown to induce apoptosis in human promyelocytic leukemia cells through the cytochrome c/caspase-9 pathway. It is a white solid and a primary reference substance with assigned absolute purity.
Uses
Used in Organic Synthesis:
Imperatorin is used as a compound in organic synthesis for its unique chemical properties and potential applications in the development of new molecules and compounds.
Used in Pharmaceutical Research:
Imperatorin is used as a research tool in the pharmaceutical industry for its anti-hypertrophic, anti-convulsant, and HIV-1 inhibitory effects. It can be further studied and potentially utilized in the development of drugs targeting these conditions.
Used in HIV-1 Research:
Imperatorin is used as an inhibitor of HIV-1 replication in primary T lymphocytes and transformed cell lines, as well as in HeLa cells. Its inhibitory effect on the virus makes it a valuable compound for research in the development of antiretroviral therapies.
Used in Cancer Research:
Imperatorin has been shown to induce apoptosis in human promyelocytic leukemia cells, making it a potential compound for research in cancer treatment and the development of anti-cancer drugs.
Used in Acetylcholinesterase Inhibition:
Imperatorin acts as an acetylcholinesterase inhibitor, which can be useful in the research and development of drugs targeting neurological disorders related to acetylcholinesterase activity.
References
https://www.scbt.com/scbt/product/imperatorin-482-44-0
https://pubchem.ncbi.nlm.nih.gov/compound/imperatorin#section=Top
https://en.wikipedia.org/wiki/Imperatorin
Biochem/physiol Actions
Imperatorin is a modulator of p38, ERK pathway. Imperatorin increases BMP-2 expression (mRNA) and increases bone density/volume and mineralization in vivo.
Check Digit Verification of cas no
The CAS Registry Mumber 482-44-0 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 4,8 and 2 respectively; the second part has 2 digits, 4 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 482-44:
(5*4)+(4*8)+(3*2)+(2*4)+(1*4)=70
70 % 10 = 0
So 482-44-0 is a valid CAS Registry Number.
InChI:InChI=1/C16H14O4/c1-10(2)5-7-19-16-14-12(6-8-18-14)9-11-3-4-13(17)20-15(11)16/h3-6,8-9H,7H2,1-2H3
482-44-0Relevant articles and documents
Structural modifier of 8-methoxypsoralen as well as preparation method and application of structural modifier
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, (2019/04/04)
The invention discloses a structural modifier of 8-methoxypsoralen as well as a preparation method and application of the . The structural modifier of the 8-methoxypsoralen provided by the invention is a compound B20 shown as a formula 1 or a compound A10 shown as a formula 2. The bacteriostatic activity of the compound B20 for enterotoxigenic escherichia coli at the concentration of 64 mu g/mL is2.3 times of that of the 8-methoxypsoralen; the bacteriostatic activity of the compound A10 for enterotoxigenic escherichia coli at the concentration of 64 mu g/mL is 2.4 times of the 8-methoxypsoralen. The compound B20 and the compound A10 can be applied to the preparation of a medicament for treating and/or preventing piglet diarrhea. The formula 1 and the formula 2 are shown in the description.
A Simple One-step Synthesis of Phenyl Ethers from Phenyl Acetates
Banerjee, Sunil K.,Gupta, Bishan D.,Singh, Kuber
, p. 815 - 816 (2007/10/02)
Phenyl acetates when refluxed with alkyl halides in acetone solution in the presence of a crown ether and anhydrous potassium carbonate undergo alkylation yielding phenyl ethers.