482-25-7 Usage
Description
BYAKANGELICIN, also known as (+)-Byakangelicin, is a naturally occurring compound derived from plants in the genus Angelica. It possesses various biological activities and has been found to have potential applications in the pharmaceutical and medical fields due to its unique properties.
Uses
Used in Pharmaceutical Applications:
BYAKANGELICIN is used as an inhibitor of sex hormones, affecting the catabolism of endogenous hormones. This property makes it a potential candidate for the development of drugs targeting hormone-related conditions.
Used in Hepatocyte Applications:
BYAKANGELICIN directly affects the cytochrome P450 isoform (CY) P3A4 in human hepatocytes, which is an essential enzyme involved in the metabolism of various drugs and substances in the liver. This interaction with CYP3A4 can be utilized in the development of drugs that modulate the activity of this enzyme, potentially improving the efficacy and safety of certain medications.
Used in Diabetic Complications Treatment:
BYAKANGELICIN is used as an inhibitor of aldose reductase, an enzyme involved in the development of diabetic cataract. By inhibiting this enzyme, BYAKANGELICIN can help in the treatment and prevention of diabetic cataract, a common complication in patients with diabetes.
Check Digit Verification of cas no
The CAS Registry Mumber 482-25-7 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 4,8 and 2 respectively; the second part has 2 digits, 2 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 482-25:
(5*4)+(4*8)+(3*2)+(2*2)+(1*5)=67
67 % 10 = 7
So 482-25-7 is a valid CAS Registry Number.
InChI:InChI=1/C17H18O7/c1-17(2,20)11(18)8-23-16-14-10(6-7-22-14)13(21-3)9-4-5-12(19)24-15(9)16/h4-7,11,18,20H,8H2,1-3H3
482-25-7Relevant articles and documents
Benzofuran and coumarin derivatives from the root of Angelica dahurica and their PPAR-γ ligand-binding activity
Matsuo, Yukiko,Yamaguchi, Emi,Hakamata, Ryo,Ootomo, Kanae,Takatori, Kazuhiro,Fukaya, Haruhiko,Mimaki, Yoshihiro
, (2020/02/26)
A phytochemical investigation of the root of Angelica dahurica led to the isolation of benzofuran and coumarin derivatives. This is the first report of the isolation and identification of three furanocoumarin sulfates from A. dahurica root. The structures of a total of twelve undescribed compounds were determined by extensive spectroscopic analysis, including 2D NMR data, hydrolysis, and solvolysis, followed by either physicochemical and spectroscopic data or X-ray crystallographic analysis. The isolated compounds were evaluated for their PPAR-γ ligand-binding activity, and six compounds showed significant PPAR-γ ligand-binding activity. In particular, the undescribed benzofuran derivative, 3-[6,7-furano-9-hydroxy-4-(2″,3″-dihydroxy-3″-methylbutyloxy)]-phenyl propionic acid, exhibited the most potent PPAR-γ ligand-binding activity and accumulated intracellular lipid in 3T3-L1 cells.