4621-66-3Relevant articles and documents
Water Mediated Direct Thioamidation of Aldehydes at Room Temperature
Gupta, Ankush,Vankar, Jigarkumar K.,Jadav, Jaydeepbhai P.,Gururaja, Guddeangadi N.
, p. 2410 - 2420 (2022/02/23)
A mild, greener approach toward thioamide synthesis has been developed. Its unique features include water-mediated reaction with no input energy, additives, or catalysts as well. The presented protocol is attractive with readily available starting materials and the use of different array amines, along with a scaled-up method. Biologically active molecules such as thionicotinamide and thioisonicotinamide can be synthesized from this procedure.
Synthesis and herbicidal activities of novel thiazole PPO inhibitors
Chen, Shu,Liu, Jie,Pei, Dan,Ren, Guihua,Shi, Jianjun,Tan, Chengxia,Xu, Tianming,Yang, Ren,Zhang, Donglin,Zhang, Fan
, p. 192 - 198 (2020/02/29)
Background: Protoporphyrinogen oxidase (PPO, EC 1.3.3.4) is a key enzyme in the biosynthesis of chlorophyll and heme, also the target of different types of herbicides. Thiazole compounds shown excellent biological activity, can be designed by using active groups docking for new PPO inhibitors. Objective: The objective of this study was to synthsize a series of aryl thiazole compounds as PPO inhibitors. Methods: In this study, a series of aryl thiazole compounds derivatives 11a-l were obtained from 2-chloro-5-nitrobenzoic acid as the starting material via esterification, Iron powder reduction, diazoti-zation, Hantzsch reaction and final acylation. All synthesized compounds have been tested for their herbicidal activities as a PPO inhibitors. Results: The Petri dish test indicated that all compounds exhibited good herbicidal activities at 200 mg/L using culture dish. And the post-emergence tests showed that at 150g.ai/ha on weed stem leaf spray treatment, some of the title compounds exhibited 80% inhibition rate against the dicotyle-donou weeds Amaranthus retroflexus and Eclipta prostrate. Conclusion: Good activity was noted for some compounds that compounds 11a, 11b, 11c, 11g, 11h had 80% inhibition on stems and leaves of Amaranthus retroflexus at 150g.ai/ha.
Production method for 2-pyridyl-4-methylthiazole-5-formic acid bisabolene ester spice
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Paragraph 0036-0040; 0052, (2020/04/06)
The invention discloses a production method for synthesizing 2-pyridyl-4-methylthiazole-5-formic acid bisabolene ester spice through solid acid catalysis. The production method comprises the steps: taking nicotinamide as a starting material, and carrying out a reaction with P2S5 to obtain thionicotinamide; carrying out a cyclization reaction on thionicotinamide and ethyl 2-chloroacetoacetate to obtain 2-pyridyl-4-methylthiazole-5-ethyl formate; and hydrolyzing to obtain 2-pyridyl-4-methylthiazole-5-formic acid, condensing with bisabolol under the action of a solid acid catalyst, and carrying out industrial column chromatography separation to efficiently synthesize the 2-pyridyl-4-methylthiazole-5-formic acid bisabolene ester spice.
