459871-11-5Relevant articles and documents
Total synthesis of deamido bleomycin A2, the major catabolite of the antitumor agent bleomycin
Zou, Ying,Fahmi, Nour Eddine,Vialas, Corine,Miller, Guy M.,Hecht, Sidney M.
, p. 9476 - 9488 (2007/10/03)
Metabolic inactivation of the antitumor antibiotic bleomycin is believed to be mediated exclusively via the action of bleomycin hydrolase, a cysteine proteinase that is widely distributed in nature. While the spectrum of antitumor activity exhibited by th