45791-36-4

Basic information

• Product Name: (R)-(+)-1-(4-BROMOPHENYL)ETHYLAMINE
• Synonyms: Benzenemethanamine, 4-bromo-α-methyl-, (αR)-;(R)-(+)-1-(4-Bromophenyl)ethylamine, ChiPros, 98%, ee 98+%;(R)-(+)-1-(4-BROMOPHENYL)ETHYLAMINE, 95%, 98% EE;(R)-(+)-1-(4-Bromophenyl)ethylamine, 98% ee;(1R)-1-(4-Bromophenyl)ethaneamine;(R)-α-Methyl-4-bromobenzylamine;(αR)-α-Methyl-4-bromobenzenemethanamine;[R,(+)]-p-Bromo-α-methylbenzenemethanamine
• CAS NO: 45791-36-4
• Molecular Formula: C₈H₁₀BrN
• Molecular Weight: 200.08
• EINECS: 256-245-0
• Product Categories: Amines;Asymmetric Synthesis;Building Blocks;C8;Chemical Synthesis;New Products for Chemical Synthesis;Nitrogen Compounds;Organic Building Blocks
• Mol File: 45791-36-4.mol
• Article Data: 27

Chemical Properties

• Melting Point: -25°C
• Boiling Point: 140-145 °C (30 mmHg)
• Flash Point: >110°C
• Appearance: clear colorless liquid
• Density: 1.390 g/mL at 20 °C(lit.)
• Vapor Pressure: 0.0134mmHg at 25°C
• Refractive Index: n20/D 1.566
• Storage Temp.: 0-10°C
• PKA: 8.82±0.10(Predicted)
• Sensitive: Air Sensitive
• BRN: 2412319
• CAS DataBase Reference: (R)-(+)-1-(4-BROMOPHENYL)ETHYLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-(+)-1-(4-BROMOPHENYL)ETHYLAMINE(45791-36-4)
• EPA Substance Registry System: (R)-(+)-1-(4-BROMOPHENYL)ETHYLAMINE(45791-36-4)

Safety Data

• Hazard Codes: C,N
• Statements: 34-51/53-22
• Safety Statements: 26-28-36/37/39-45-61
• RIDADR: UN 2735 8/PG 3
• WGK Germany: 3
• F: 10-23
• HazardClass: 8
• PackingGroup: II
• Hazardous Substances Data: 45791-36-4(Hazardous Substances Data)

Usage

Chemical Properties

clear colorless liquid

InChI:InChI=1/C8H10BrN/c1-6(10)7-2-4-8(9)5-3-7/h2-6H,10H2,1H3/t6-/m1/s1

Upstream product

• 24358-62-1 1-(4-bromophenyl)ethylamine 
• 3886-69-9 (R)-1-phenyl-ethyl-amine 
• 1585-07-5 1-bromo-4-ethylbenzene 
• 1434603-04-9 (Z)-1-(4-bromophenyl)ethanone O-benzyloxime 
• 71426-51-2 anti-α,4'-dibromoacetophenone oxime 
• 99-73-0 para-bromophenacyl bromide 
• 99-90-1 para-bromoacetophenone 
• 1122-91-4 4-bromo-benzaldehyde 
• 220441-76-9 (R)-2-(4-Bromo-phenyl)-4-phenyl-oxazolidine 
• 871720-04-6 (R)-N-(1-(4-bromophenyl)ethyl)-2,2,2-trifluoroacetamide 
• 131214-13-6 (2R,1'R)-2-<<1'-(4-bromophenyl)ethyl>amino>-2-phenylethanol 

Downstream Products

• 656237-73-9 N-[(1R)-1-(4-bromophenyl)ethyl]-4-methyl-3-nitropyridin-2-amine 
• 578729-21-2 [(R)-1-(4-bromo-phenyl)-ethyl]-carbamic acid tert-butyl ester 
• 618461-78-2 (R)-1-(4-bromophenyl)ethyl isocyanate 
• 177750-53-7 N-[(1R)-1-(4-bromophenyl)ethyl]acetamide 
• 871676-32-3 (R)-5-[1-(4-bromo-phenyl)-ethylcarbamoyl]-thiophene-2-carboxylic acid methyl ester 
• 1134776-30-9 (R)-4-(1-tert-butoxycarbonylaminoethyl)benzoic acid 
• 210488-53-2 4-[(1R)-1-aminoethyl]benzonitrile 
• 943152-85-0 (R)-2-[1-(4-bromo-phenyl)-ethyl]-isoindole-1,3-dione 
• 877131-04-9 (R)-ethanesulfonic acid [1-(4-bromo-phenyl)-ethyl]-amide 
• 863782-76-7 (R,R)-N,N'-bis[1-(4-bromophenyl)ethyl]oxalylamide 
• 749928-16-3 N-[(1R)-1-(4-bromophenyl)ethyl]methanesulfonamide 

Relevant articles and documents

Synthesis method of garafloxacin intermediate

The invention discloses a synthesis method of a garafloxacin intermediate (1R)-5-bromo-2, 3-dihydro-1-methyl-1H-isoindole; the synthesis method comprises the following steps of: taking a garafloxacin intermediate as a raw material; the method comprises the following steps: step 1, by taking R(+)-alpha-phenylethylamine as a raw material and lewis acid as a catalyst, carrying out bromine bromination reaction to obtain a compound 2; 2, placing the compound 2 in a solvent, adding hydrochloric acid, paraformaldehyde and a catalyst, and carrying out chloromethylation reaction to obtain a compound 3; 3, dissolving the compound 3 in a solvent, adding alkali, and heating the mixture for reaction to obtain a compound 1. The method is simple in reaction, short in route, less in three wastes, environment-friendly, high in yield of each step, less in waste of raw materials and reagents, and especially suitable for industrial production.

Asymmetric Synthesis of Chiral Primary Amines by Ruthenium-Catalyzed Direct Reductive Amination of Alkyl Aryl Ketones with Ammonium Salts and Molecular H2

A ruthenium/C3-TunePhos catalytic system has been identified for highly efficient direct reductive amination of simple ketones. The strategy makes use of ammonium acetate as the amine source and H2 as the reductant and is a user-friendly and operatively simple access to industrially relevant primary amines. Excellent enantiocontrol (>90% ee for most cases) was achieved with a wide range of alkyl aryl ketones. The practicability of this methodology has been highlighted by scalable synthesis of key intermediates of three drug molecules. Moreover, an improved synthetic route to the optimal diphosphine ligand C3-TunePhos is also presented.

Synthesis and pKa determination of new enantiopure dimethyl-substituted acridino-crown ethers containing a carboxyl group: Useful candidates for enantiomeric recognition studies

New enantiopure dimethyl-substituted acridino-18-crown-6 and acridino-21-crown-7 ethers containing a carboxyl group at position 9 of the acridine ring [(S,S)-8, (S,S)-9, (R,R)-10] were synthesized. The pKa values of the new crown ethers [(S,S)-8, (S,S)-9, (R,R)-10] and of an earlier reported macrocycle [(R,R)-2] were determined by UV-pH titrations. Crown ether (S,S)-8 was attached to silica gel by covalent bonds and the enantiomeric separation ability of the newly prepared chiral stationary phase [(S,S)-CSP-12] was studied by high-performance liquid chromatography (HPLC). Homochiral preference was observed and the best separation was achieved for the enantiomers of 1-NEA. Ligands (S,S)-9 and (R,R)-10 are precursors of enantioselective sensor and selector molecules for the enantiomers of protonated primary amines, amino acids, and their derivatives.