457-49-8 Usage
Description
Cyclohexyltrifluoroacetone, with the molecular formula C9H11F3O, is a colorless liquid characterized by a strong, sweet odor. It is a versatile chemical compound known for its high reactivity and ability to form stable complexes with metal ions, which makes it valuable in various industrial and research applications.
Uses
Used in Chemical Synthesis:
Cyclohexyltrifluoroacetone is used as a building block in organic synthesis for its ability to undergo various chemical transformations, contributing to the creation of a wide range of compounds.
Used in Solvent Applications:
As a solvent, Cyclohexyltrifluoroacetone is utilized in numerous chemical reactions due to its compatibility with a variety of substances and its capacity to dissolve many types of compounds.
Used in Metal Extraction and Separation:
Cyclohexyltrifluoroacetone is used as a reagent for the extraction and separation of metals, capitalizing on its ability to form stable complexes with metal ions, which aids in the efficient separation and purification processes.
Used in Pharmaceutical Production:
In the pharmaceutical industry, Cyclohexyltrifluoroacetone plays a role in the production of various drugs, serving as a key intermediate in the synthesis of medicinal compounds.
Overall, Cyclohexyltrifluoroacetone is a multifaceted compound with applications that span across chemical synthesis, solvent usage, metal extraction, and pharmaceutical production, highlighting its significance in both industrial and research settings.
Check Digit Verification of cas no
The CAS Registry Mumber 457-49-8 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 4,5 and 7 respectively; the second part has 2 digits, 4 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 457-49:
(5*4)+(4*5)+(3*7)+(2*4)+(1*9)=78
78 % 10 = 8
So 457-49-8 is a valid CAS Registry Number.
InChI:InChI=1/C9H13F3O/c10-9(11,12)8(13)6-7-4-2-1-3-5-7/h7H,1-6H2
457-49-8Relevant articles and documents
Stereoconvergent negishi arylations of racemic secondary alkyl electrophiles: Differentiating between a CF3 and an alkyl group
Liang, Yufan,Fu, Gregory C.
supporting information, p. 9523 - 9526 (2015/08/18)
In this report, we establish that a readily available nickel/bis(oxazoline) catalyst accomplishes a wide array of enantioconvergent cross-couplings of arylzinc reagents with CF3-substituted racemic secondary alkyl halides, a process that necessitates that the chiral catalyst be able to effectively distinguish between a CF3 and an alkyl group in order to provide good ee. We further demonstrate that this method can be applied without modification to the catalytic asymmetric synthesis of other families of fluorinated organic compounds.
Oxidation of α-trifluoromethyl alcohols using a recyclable oxoammonium salt
Kelly, Christopher B.,Mercadante, Michael A.,Hamlin, Trevor A.,Fletcher, Madison H.,Leadbeater, Nicholas E.
, p. 8131 - 8141 (2013/01/15)
A simple, mild method for the oxidation of α-trifluoromethyl alcohols to trifluoromethyl ketones (TFMKs) using the oxoammonium salt 4-acetylamino-2,2,6,6-tetramethylpiperidine-1-oxoammonium tetrafluoroborate (1) is described. Under basic conditions, oxidation proceeds rapidly and affords good to excellent yields of TFMKs, without concomitant formation of the hydrate. The byproduct of the oxidation, 4-acetylamino-2,2,6,6-tetramethyl-1- piperidinyloxy (1c), is easily recovered and can be conveniently reoxidized to regenerate the oxoammonium salt.
