456-49-5

Basic information

• Product Name: 3-Fluoroanisole
• Synonyms: M-FLUORO METHOXYBENZENE;M-FLUOROANISOLE;1-Fluoro-3-methoxybenzene;1-fluoro-3-methoxy-benzene;Benzene, 1-fluoro-3-methoxy-;3-Fluoroanisole,99%;3-Fluoroanisole 99%;m-Fluorophenyl methyl ether
• CAS NO: 456-49-5
• Molecular Formula: C₇H₇FO
• Molecular Weight: 126.13
• EINECS: 207-267-4
• Product Categories: Other fluorin-contained compounds;AnisoleSeries;Fluorobenzene;Anisoles, Alkyloxy Compounds & Phenylacetates;Fluorine Compounds;Ethers;Organic Building Blocks;Oxygen Compounds
• Mol File: 456-49-5.mol
• Article Data: 47

Chemical Properties

• Melting Point: -35°C
• Boiling Point: 158 °C743 mm Hg(lit.)
• Flash Point: 111 °F
• Appearance: clear colorless to straw yellow liquid
• Density: 1.104 g/mL at 25 °C(lit.)
• Vapor Pressure: 38.3mmHg at 25°C
• Refractive Index: n20/D 1.488(lit.)
• Storage Temp.: Flammables area
• Solubility: Chloroform, Methanol
• BRN: 1858895
• CAS DataBase Reference: 3-Fluoroanisole(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Fluoroanisole(456-49-5)
• EPA Substance Registry System: 3-Fluoroanisole(456-49-5)

Safety Data

• Hazard Codes: F
• Statements: 10
• Safety Statements: 16
• RIDADR: UN 1993 3/PG 3
• WGK Germany: 3
• HazardClass: 3
• PackingGroup: III
• Hazardous Substances Data: 456-49-5(Hazardous Substances Data)

Usage

Description

3-Fluoroanisole is an organic compound that features a fluorine atom attached to a methoxy group, which is connected to a benzene ring. It is known for its unique chemical properties and reactivity, making it a valuable intermediate in various chemical reactions and synthesis processes.

Uses

Used in Pharmaceutical Industry:
3-Fluoroanisole is used as a synthetic intermediate for the preparation of tertiary benzylic nitriles, which are important building blocks in the synthesis of various pharmaceutical compounds. These nitriles can be further converted into amines, amides, and other functional groups, contributing to the development of new drugs with potential therapeutic applications.
Used in Chemical Research:
3-Fluoroanisole is utilized in the synthesis of various organic compounds, such as 4-fluoro-5,6-dihydroxytryptamine, 3-fluoro-, and 5-fluoronoradrenaline. These synthesized compounds are valuable for studying the structure-activity relationships of biologically active molecules and can be used as probes in understanding the mechanisms of various biological processes.

InChI:InChI=1/C7H5F3O/c8-7(9,10)11-6-4-2-1-3-5-6/h1-5H

Upstream product

• 536-90-3 m-Anisidine 
• 79421-99-1 tris(3-methoxyphenyl)-1,3,5,2,4,6-trioxatriborinane 
• 10365-98-7 3-methoxyphenylboronic acid 
• 458-50-4 1-bromo-2-fluoro-4-methoxybenzene 
• 325142-84-5 3-methoxyphenylboronic acid pinacol ester 
• 1250409-81-4 2-methoxyphenyliodonium-(5-[2,2-dimethyl-1,3-dioxane-4,6-dione])ylide 
• 162101-31-7 (2-fluoro-4-methoxyphenyl)boronic acid 
• 150-19-6 O-methylresorcine 
• 115991-13-4 bis(4-methoxyphenyl)iodonium fluoride 
• 104-92-7 1-bromo-4-methoxy-benzene 
• 2398-37-0 3-methoxyphenyl bromide 
• 66107-29-7 4-methoxyphenyl triflate 
• 2386-64-3 ethylmagnesium chloride 
• 16308-14-8 4-methoxy(diacetoxyiodo)benzene 

Downstream Products

• 129448-63-1 1-(2-fluoro-4-methoxyphenyl)-2-phenylethanone 
• 40586-05-8 7-(3-methoxyphenyl)heptan-1-ol 
• 192443-25-7 3-(4-bromo-phenyl)-6-methoxy-benzo[b]thiophene 
• 192436-87-6 (4-bromophenyl)(4-methoxy-2-methylsulfanylphenyl)methanone 
• 423161-73-3 3-(4-bromo-phenyl)-benzo[b]thiophen-6-ol 
• 192437-40-4 (4-bromophenyl)(4-hydroxy-2-methylsulfanylphenyl)methanone 
• 1026316-32-4 6-(6-bromo-hexyloxy)-3-(4-bromo-phenyl)-benzo[b]thiophene 
• 192437-42-6 [4-[6-(bromo)hexyloxy]-2-methylsulfanylphenyl](4-bromophenyl)methanone 
• 192443-17-7 3-(4-bromophenyl)benzo[d]isothiazol-6-ol 
• 79418-78-3 3-fluoro-4-hydroxy-5-methoxybenzaldehyde 
• 1089186-95-7 1-(3-fluoro-4-hydroxy-5-methoxyphenyl)-N,N,N-trimethylmethanaminium iodide 
• 99424-78-9 3,4-dimethoxy-5-fluorophenethylamine 
• 71924-61-3 3-fluoro-4,5-dimethoxybenzaldehyde 

Relevant articles and documents

A Convenient and Stable Heterogeneous Nickel Catalyst for Hydrodehalogenation of Aryl Halides Using Molecular Hydrogen

Hydrodehalogenation is an effective strategy for transforming persistent and potentially toxic organohalides into their more benign congeners. Common methods utilize Pd/C or Raney-nickel as catalysts, which are either expensive or have safety concerns. In this study, a nickel-based catalyst supported on titania (Ni-phen@TiO2-800) is used as a safe alternative to pyrophoric Raney-nickel. The catalyst is prepared in a straightforward fashion by deposition of nickel(II)/1,10-phenanthroline on titania, followed by pyrolysis. The catalytic material, which was characterized by SEM, TEM, XRD, and XPS, consists of nickel nanoparticles covered with N-doped carbon layers. By using design of experiments (DoE), this nanostructured catalyst is found to be proficient for the facile and selective hydrodehalogenation of a diverse range of substrates bearing C?I, C?Br, or C?Cl bonds (>30 examples). The practicality of this catalyst system is demonstrated by the dehalogenation of environmentally hazardous and polyhalogenated substrates atrazine, tetrabromobisphenol A, tetrachlorobenzene, and a polybrominated diphenyl ether (PBDE).

Efficient synthesis method of meta-fluoranisole (by machine translation)

The method is characterized by comprising the following steps: taking m-chloronitrobenzene as a raw material, carrying out high-temperature chlorination reaction, nitration reaction and fluorination reaction to obtain 2,4 - 2,4 -difluorobenzene and carrying out a methoxylation reaction with m-difluorobenzene as a raw material and carrying out methoxylation reaction to obtain m-fluorobenzyl ether; and the hydrogenation catalyst is a porous alumina loaded NiO-Co222O3-MoOO3 composite catalyst. The method disclosed by the invention is simple in process and high in product yield. (by machine translation)

Application of trivalent iodine compounds as catalysts in Bal-Schiemann reaction

The invention discloses an application of trivalent iodine compounds shown in formula I and/or II in the description and used as catalysts in Bal-Schiemann reaction. The trivalent iodine compounds areused as the catalysts in the Bal-Schiemann reaction, so that the Bal-Schiemann reaction can be conducted at room temperature or near room temperature when a thermochemical method is used, and the reaction has mild reaction conditions, wide substrate use range and short reaction time, and is safe and easy to operate, products are easy to separate, and raw materials are simple and low in toxicity.