455-15-2

Basic information

• Product Name: 4-FLUOROPHENYL METHYL SULFONE
• Synonyms: Sulfone, p-fluorophenyl methyl;4-FLUOROPHENYL METHYL SULPHONE;4-FLUOROPHENYL METHYL SULFONE;1-FLUORO-4-(METHYLSULFONYL)BENZENE;1-fluoro-4-(methylsulphonyl)benzene;4-Fluorophenylmethylsulfone,97%;4-Fluorobenzenesulfinic Acid Methyl Este;4-Fluorophenyl
• CAS NO: 455-15-2
• Molecular Formula: C₇H₇FO₂S
• Molecular Weight: 174.19
• EINECS: 207-237-0
• Product Categories: Aromatics Compounds;Aromatics;Sulfur & Selenium Compounds;Organic Building Blocks;Sulfones;Sulfur Compounds
• Mol File: 455-15-2.mol
• Article Data: 73

Chemical Properties

• Melting Point: 78-81 °C(lit.)
• Boiling Point: 95-97°C 7mm
• Flash Point: 132.8 °C
• Appearance: Almost white/Adhering Crystalline Powder
• Density: 1.2768 (estimate)
• Vapor Pressure: 0.00261mmHg at 25°C
• Refractive Index: 1.507
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: Chloroform, Dichloromethane, Dimethyl Sulfoxide, Methanol
• BRN: 2045674
• CAS DataBase Reference: 4-FLUOROPHENYL METHYL SULFONE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-FLUOROPHENYL METHYL SULFONE(455-15-2)
• EPA Substance Registry System: 4-FLUOROPHENYL METHYL SULFONE(455-15-2)

Safety Data

• Hazard Codes: Xn,Xi
• Statements: 22
• Safety Statements: 24/25
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 455-15-2(Hazardous Substances Data)

Usage

Description

4-Fluorophenyl methyl sulfone is an organic compound characterized by its white solid appearance. It is a derivative of phenyl methyl sulfone with a fluorine atom substitution at the 4th position, which imparts unique chemical properties to the molecule.

Uses

Used in Pharmaceutical Industry:
4-Fluorophenyl methyl sulfone is used as a key intermediate in the synthesis of various pharmaceutical compounds. Its unique chemical structure allows it to be a versatile building block for the development of new drugs with potential therapeutic applications.
1. Preparation of Substituted Indazole Amides:
In the pharmaceutical industry, 4-Fluorophenyl methyl sulfone is used as a starting material for the preparation of substituted indazole amides. These compounds serve as glucokinase activators, which play a crucial role in regulating blood glucose levels and have potential applications in the treatment of type 2 diabetes.
2. Synthesis of 4-(4′-Trifluoromethoxyphenoxy)Phenyl Methyl Sulfone:
Another application of 4-Fluorophenyl methyl sulfone in the pharmaceutical industry is its use in the preparation of 4-(4′-trifluoromethoxyphenoxy)phenyl methyl sulfone. 4-FLUOROPHENYL METHYL SULFONE has potential applications in the development of new drugs targeting various diseases and conditions.

InChI:InChI=1/C7H7FO2S/c1-11(9,10)7-4-2-6(8)3-5-7/h2-5H,1H3

Upstream product

• 462-06-6 fluorobenzene 
• 7143-01-3 Methanesulfonic anhydride 
• 74-88-4 methyl iodide 
• 67-56-1 methanol 
• 824-80-6 sodium 4-fluorobenzenesulfinate 
• 459-45-0 4-fluorobenzenediazonium tetrafluoroborate 
• 349-88-2 4-Fluorobenzenesulfonyl chloride 
• 2266-41-3 4-fluorobenzenesulfonylhydrazide 
• 405-31-2 bis(4-fluorophenyl)disulfide 
• 371-42-6 4-Fluorothiophenol 
• 402-46-0 4-fluorophenylsulphonamide 
• 868-85-9 Dimethyl phosphite 
• 4052-30-6 4-methylsulfonylbenzoic acid 
• 616-42-2 dimethylsulfite 

Downstream Products

• 752242-45-8 3-hydroxy-5-(4-methanesulfonylphenoxy)benzoic acid methyl ester 
• 401564-98-5 3-[(2S,4S)-1-tert-butoxycarbonyl-4-(4-methanesulfonylphenyl)amino-2-pyrrolidinylcarbonyl]-1,3-thiazolidine 
• 190200-82-9 1-[4-(methylsulfonyl)phenyl]-1H-imidazole 

Relevant articles and documents

High Chemoselectivity in the Construction of Aryl Methyl Sulfones via an Unexpected C-S Bond Formation between Sulfonylhydrazides and Dimethyl Phosphite

A highly chemoselective route to aryl methyl sulfones via an unexpected C S bond formation between sulfonylhydrazides and dimethyl phosphite catalyzed by NaI under mild conditions has been established. This transformation provides an alternative and metal-free pathway to acquire various aryl methyl sulfones in good to excellent yields. Notably, dimethyl phosphite was employed as a stable and readily available alkyl source.

Synergistic cooperative effect of CF3SO2Na and bis(2-butoxyethyl)ether towards selective oxygenation of sulfides with molecular oxygen under visible-light irradiation

A safe, practical and eco-friendly method for the switchable synthesis of sulfoxides and sulfones through visible-light-initiated oxygenation of sulfides at ambient temperature under transition-metal-, additives-free and minimal solvent conditions. The synergistic catalytic efforts between CF3SO2Na and 2-butoxyethyl ether represents the key promoting factor for the reaction. This journal is

PROTEIN-MACROMOLECULE CONJUGATES AND METHODS OF USE THEREOF

The present disclosure provides protein-macromolecule conjugates, releasable linkers, and macromolecules, as defined herein. The disclosed conjugates provide unique properties that are based at least upon the properties of linker and number of linker-Macromolecule moieties. Also provided herein are a method of synthesis and use of conjugates in treating diseases and disorders.