452972-08-6

Basic information

• Product Name: 2-BROMOPYRIDIN-3-YLBORONIC ACID
• Synonyms: 2-BROMO-3-PYRIDINEBORONIC ACID;2-BROMO-3-PYRIDYLBORONIC ACID;2-BROMOPYRIDIN-3-YLBORONIC ACID;2-BROMOPYRIDINE-3-BORONIC ACID;2-BROMOPYRIDINE-3-YLBORONIC ACID;AKOS BRN-0505;Boronic acid, (2-bromo-3-pyridinyl)- (9CI);2-Bromopyridine-3-boronic acid 96%
• CAS NO: 452972-08-6
• Molecular Formula: C5H5BBrNO2
• Molecular Weight: 201.81
• EINECS: 1312995-182-4
• Product Categories: BORONICACID;blocks;BoronicAcids;Bromides;Pyridines;Boronic Acids & Esters;Organoborons;Pyridine;Boronic acid;Boronic Acids & Esters;Boronate Ester;Potassium Trifluoroborate
• Mol File: 452972-08-6.mol
• Article Data: 2

Chemical Properties

• Melting Point: 132 °C(dec.)
• Boiling Point: 374.311 °C at 760 mmHg
• Flash Point: 180.177 °C
• Appearance: /
• Density: 1.78 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.602
• Storage Temp.: Keep Cold
• PKA: 6.61±0.58(Predicted)
• Sensitive: Air Sensitive
• CAS DataBase Reference: 2-BROMOPYRIDIN-3-YLBORONIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2-BROMOPYRIDIN-3-YLBORONIC ACID(452972-08-6)
• EPA Substance Registry System: 2-BROMOPYRIDIN-3-YLBORONIC ACID(452972-08-6)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 22-36/37/38
• Safety Statements: 26-36
• HazardClass: IRRITANT
• Hazardous Substances Data: 452972-08-6(Hazardous Substances Data)

Usage

Chemical Properties

White solid

InChI:InChI=1/C5H5BBrNO2/c7-5-4(6(9)10)2-1-3-8-5/h1-3,9-10H

Upstream product

• 19755-53-4 2-bromo-3-nitropyridine 
• 4214-75-9 2-amino-3-nitropyridine 
• 39856-58-1 3-amino-2-bromopyridine 
• 13534-89-9 2,3-dibromopyridine 
• 109-04-6 2-bromo-pyridine 

Relevant articles and documents

DIHYDROXY(3-PYRIDYL)BORANE COMPOUNDS

A dihydroxy(3-pyridyl)borane compound of the formula (1): wherein R1 represents a hydrogen atom, halogen atom or alkoxycarbonylamino group; R2 represents a hydrogen atom, halogen atom, alkyl group or fluoroalkyl group; with the proviso that the case wherein both R1 and R2 are hydrogen atoms is excepted.

Synthesis of novel halopyridinylboronic acids and esters. Part 2: 2,4, or 5-Halopyridin-3-yl-boronic acids and esters

This paper describes a general method for the synthesis and the isolation of novel 2,4, or 5-halopyridin-3-yl-boronic acids and esters 4, 7, 10, 13, 15. These compounds are prepared taking into account a regioselective halogen-metal exchange using nBuLi or a regioselective ortho-lithiation using lithium diisopropylamide and subsequent quenching with triisopropylborate starting from appropriate mono or dihalopyridines. All substrates studied to date provided a single regioisomeric boronic acid or ester product. Additionally, these compounds have been found to undergo Pb-catalyzed coupling with a range of arylhalides and authorize a strategy to produce new pyridines libraries.