4499-83-6Relevant articles and documents
Iodine-Promoted Metal-Free Aromatization: Synthesis of Biaryls, Oligo p-Phenylenes and A-Ring Modified Steroids
Domingo, Victoriano,Prieto, Consuelo,Castillo, Alexis,Silva, Lucia,Quílez Del Moral, José F.,Barrero, Alejandro F.
, p. 3359 - 3364 (2015/11/03)
We describe efficient procedures based on the use of iodine for the synthesis of biaryls from arylcyclohexenols or arylcyclohexanols using sub-stoichiometric/catalytic iodine and dimethyl sulfoxide (DMSO) as oxidant. Heteroarylcyclohexanols also produced the corresponding biaryl products. It was proven that biphenyl can also be efficiently obtained when the quantity of iodine was reduced to 0.05 equiv. The method is compatible with different functional groups in the aromatic ring (either electron-donating or electron-withdrawing groups). For substrate scope, apart from cyclohexanone and cyclohexenone, some substituted cyclohexanones were also used to synthesize the starting arylcyclohexanols. The process was applied to the synthesis of oligo p-phenylenes and A-ring aromatized steroids, where the combined use of I2/DMSO not only provoked the necessary migration of the methyl group at C-10, but also further extended the conjugation.
Easy synthesis of phenyl oligomers using a Ni complex
Peres, Laura O.,Guillet, Francoise,Froyer, Gerard
, p. 452 - 454 (2007/10/03)
In this work are described the syntheses of p-sexiphenyl and p-octiphenyl starting from 4-bromo-p-terphenyl and 4-bromo-p-quaterphenyl, respectively, by using a nickel complex in the presence of bipyridine with DMF as solvent. This type of synthesis was shown to give an improved yield as well as easy preparation and purification of these phenylene oligomers.
One Pot Synthesis of p-Polyphenyls via the Intramolecular Cyclization of 3-Dimethylaminohex-5-en-1-ynes
Unroe, Marilyn R.,Reinhardt, Bruce A.
, p. 981 - 986 (2007/10/02)
Para linked polyphenyls of various molecular weights are conveniently synthesized from p-bis(3-dimethylamino-1-propynyl)arenes and 1-aryl-2-propenyl bromides in moderate yields using a three step, one-pot procedure.
