4491-47-8

Basic information

• Product Name: 4-ISOPROPYLIDENE-2-PHENYL-5(4H)-OXAZOLE
• Synonyms: 4-ISOPROPYLIDENE-2-PHENYL-5(4H)-OXAZOLE;2-phenyl-4-(propan-2-ylidene)oxazol-5(4H)-one;2-phenyl-4-propan-2-ylidene-1,3-oxazol-5-one
• CAS NO: 4491-47-8
• Molecular Formula: C₁₂H₁₁NO₂
• Molecular Weight: 201.22124
• Mol File: 4491-47-8.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 291.6°Cat760mmHg
• Flash Point: 127.7°C
• Appearance: /
• Density: 1.14g/cm³
• Vapor Pressure: 0.00193mmHg at 25°C
• Refractive Index: 1.571
• CAS DataBase Reference: 4-ISOPROPYLIDENE-2-PHENYL-5(4H)-OXAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-ISOPROPYLIDENE-2-PHENYL-5(4H)-OXAZOLE(4491-47-8)
• EPA Substance Registry System: 4-ISOPROPYLIDENE-2-PHENYL-5(4H)-OXAZOLE(4491-47-8)

Safety Data

• Hazardous Substances Data: 4491-47-8(Hazardous Substances Data)

Usage

Description

4-ISOPROPYLIDENE-2-PHENYL-5(4H)-OXAZOLE is an organic compound that belongs to the oxazole group. It is a colorless, flammable liquid with a molecular formula of C12H11NO. This chemical is known for its unique chemical properties and reactivity, making it a valuable component in various applications.

Uses

Used in Pharmaceutical Industry:
4-ISOPROPYLIDENE-2-PHENYL-5(4H)-OXAZOLE is used as a building block for the synthesis of various pharmaceuticals. Its unique chemical properties and reactivity contribute to the development of new and innovative medications.
Used in Chemical Industry:
4-ISOPROPYLIDENE-2-PHENYL-5(4H)-OXAZOLE is used as a reagent in organic synthesis. Its ability to participate in various chemical reactions makes it a useful component in the creation of different organic compounds.
Used as a Solvent:
In chemical reactions, 4-ISOPROPYLIDENE-2-PHENYL-5(4H)-OXAZOLE is utilized as a solvent. Its properties allow it to effectively dissolve and facilitate reactions between other compounds, making it a valuable asset in the chemical industry.

InChI:InChI=1/C12H11NO2/c1-8(2)10-12(14)15-11(13-10)9-6-4-3-5-7-9/h3-7H,1-2H3

Upstream product

• 1199-01-5 2-phenylazlactone 
• 67-64-1 acetone 
• 14598-98-2 α-benzoylamino-β-hydroxy-isovaleric acid 
• 108-24-7 acetic anhydride 
• 110-86-1 pyridine 
• 19746-96-4 2-benzoylamino-3-methyl-but-2-enoyl azide 
• 495-69-2 Hippuric Acid 
• 13166-10-4 isopropylidenemalonodinitrile 
• 186581-53-3 diazomethane 
• 37791-41-6 4-ethylidene-2-phenyl-5-oxazolone 
• 1738-64-3 2-benzoylamino-3-methyl-crotonic acid 
• 93-97-0 benzoic acid anhydride 
• 52-66-4 DL-Penicillamin 
• 98-88-4 benzoyl chloride 

Downstream Products

• 26924-22-1 methyl 2-benzamido-3-methylbut-2-enoate 
• 34297-28-4 S-methyl-DL-penicillamine 
• 5398-45-8 N-benzoyl-S-benzyl-DL-penicillamine 
• 123102-62-5 2-benzoylamino-3-methyl-crotonohydroxamic acid 
• 60676-53-1 2-benzoylamino-3-methyl-crotonic acid anilide 
• 102010-56-0 N,S-dibenzyl-penicillamine 
• 172798-59-3 N-(2-benzoylamino-3-methyl-crotonoyl)-β-alanine 
• 51932-22-0 2-Phenyl-5,5-dimethyl-2-thiazoline-4-carboxylic acid 
• 91641-20-2 α-benzoylamino-β-mercapto-thioisovaleric acid 
• 19739-55-0 2-benzoylamino-3-methyl-crotonic acid hydrazide 
• 1738-64-3 2-benzoylamino-3-methyl-crotonic acid 
• 61131-42-8 N-benzoyl-valine ethyl ester 
• 88612-31-1 2-benzoylamino-3-methyl-thiocrotonic acid 
• 35352-73-9 4-isopropylidene-2-phenyl-4H-thiazol-5-one 

Relevant articles and documents

A simple and convenient synthesis of 4-ylidene-5(4H)oxazolone derivatives: Oxazolone ring transformation leading to other heterocyclic structures

Simple, effective, and high yield synthetic procedure for the synthesis of 4-ylidene-5(4H)-oxazolones 2a-m from arylidene-malononitriles under solvent-free conditions is described. The scope of this reaction was investigated, and it was found that the presence of anhydrous sodium acetate gave the corresponding oxazolones in excellent yields. The newly generated oxazolone derivative 2m underwent ring transformation into pyrroles, imidazoles, pyridazine, and triazines.