4468-47-7

Basic information

• Product Name: 2-CYANO-3-BUTANONE
• Synonyms: 2-METHYL-3-OXOBUTANENITRILE;2-CYANO-3-BUTANONE;α-Acetylpropionitrile;3-CYANO-2-BUTANONE;Butanenitrile, 2-methyl-3-oxo-
• CAS NO: 4468-47-7
• Molecular Formula: C₅H₇NO
• Molecular Weight: 97.12
• Mol File: 4468-47-7.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 182-184 °C(Press: 745 Torr)
• Appearance: /
• Density: 0.9794 g/cm3
• CAS DataBase Reference: 2-CYANO-3-BUTANONE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-CYANO-3-BUTANONE(4468-47-7)
• EPA Substance Registry System: 2-CYANO-3-BUTANONE(4468-47-7)

Safety Data

• Hazardous Substances Data: 4468-47-7(Hazardous Substances Data)

Usage

General Description

2-Cyano-3-butanone, also known as ethyl cyanoacetate, is a chemical compound with the molecular formula C5H7NO. It is a colorless liquid with a fruity odor and is commonly used as a flavoring agent in the food industry. 2-Cyano-3-butanone is also used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. It is a versatile building block in organic chemistry and is used in the production of various compounds, including esters, amides, and carboxylic acids. Additionally, it is used as a solvent and as a reagent in organic synthesis reactions. However, it is important to handle this compound with care as it is flammable and can be harmful if ingested or inhaled.

Upstream product

• 141-78-6 ethyl acetate 
• 107-12-0 propiononitrile 
• 123-86-4 acetic acid butyl ester 
• 74-88-4 methyl iodide 
• 143-33-9 sodium cyanide 
• 4091-39-8 3-chloro-2-butanone 
• 64-19-7 acetic acid 
• 64-17-5 ethanol 
• 151-50-8 potassium cyanide 
• 75-36-5 acetyl chloride 
• 13435-20-6 tetraethylammoniumcyanide 
• 814-75-5 3-bromo-butanone 
• 75-05-8 acetonitrile 
• 19481-82-4 2-bromopropionitrile 

Downstream Products

• 51143-42-1 3,4-dimethyl-1-phenyl-1H-pyrazol-5-amine 
• 82471-44-1 2-Acetyl-2-methyl-succinonitrile 
• 1247725-90-1 4'-[(2-propyl-1H-benzimidazol-1-yl)methyl]-N-(3,4-dimethyl-5-isoxazolyl)-[1,1'-biphenyl]-2-sulfonamide 
• 1247725-91-2 4'-[(2-butyl-1H-benzimidazol-1-yl)methyl]-N-(3,4-dimethyl-5-isoxazolyl)-[1,1'-biphenyl]-2-sulfonamide 
• 1393601-31-4 4'-[(2-butyl-6-methyl-1H-benzimidazol-1-yl)methyl]-N-(3,4-dimethyl-5-isoxazolyl)-[1,1'-biphenyl]-2-sulfonamide 
• 1393601-32-5 4'-[(2-butyl-6-methoxy-1H-benzimidazol-1-yl)methyl]-N-(3,4-dimethyl-5-isoxazolyl)-[1,1'-biphenyl]-2-sulfonamide 
• 1393601-46-1 C₃₄H₄₀N₄O₅S 
• 1393601-47-2 C₃₄H₄₀N₄O₆S 
• 1393601-48-3 C₃₃H₃₇ClN₄O₅S 
• 1393601-49-4 C₃₃H₃₇BrN₄O₅S 
• 1393601-50-7 C₃₃H₃₇FN₄O₅S 
• 1393601-51-8 C₃₄H₃₇F₃N₄O₅S 
• 1393601-52-9 C₃₃H₃₇N₅O₇S 
• 1247725-83-2 4'-[(1H-benzimidazol-1-yl)methyl]-N-(3,4-dimethyl-5-isoxazolyl)-[1,1'-biphenyl]-2-sulfonamide 

Relevant articles and documents

Synthesis and biological evaluation of 4′-[(benzimidazole-1-yl) methyl]biphenyl-2-sulfonamide derivatives as dual angiotensin II/endothelin A receptor antagonists

A series of 4′-[(benzimidazole-1-yl)methyl]biphenyl-2-sulfonamide derivatives (Ia-Il) were synthesized and biologically evaluated. It was found that Ig, the most active compound, antagonized both Ang II AT1 and endothelin ETA receptors (AT1 IC50 = 8.5, ETA IC50 = 8.9 nM), and was more potent than losartan in RHRs with no significant effect on heart rate. The preliminary structure-activity relationships were also discussed in the present paper.

Preparation of optically pure α-alkyl β-hydroxy nitriles by the Baker's yeast reduction

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