4395-98-6

Basic information

• Product Name: 4-Cyanopiperidine
• Synonyms: 4-CYANOPIPERIDINE;CHEMBRDG-BB 4009819;PIPERIDINE-4-CARBONITRILE;4-CYANOPIPERIDINE >98%;4-CYANO PIPERIDINE PIPERIDINE-4-CARBONITRILE;5-AMINOPHTHALONITRILE;piperidine-4-carbonitrile(SALTDATA: HCl);4-cyanopiperdine
• CAS NO: 4395-98-6
• Molecular Formula: C₆H₁₀N₂
• Molecular Weight: 110.16
• EINECS: 1308068-626-2
• Product Categories: Amines and Anilines;Boron, Nitrile, Thio,& TM-Cpds;Piperidine;Aromatics
• Mol File: 4395-98-6.mol
• Article Data: 22

Chemical Properties

• Melting Point: 0°C
• Boiling Point: 0°C
• Flash Point: 0°C
• Appearance: Colorless to pale yellow/Liquid
• Density: 0.987 g/mL at 25 °C
• Vapor Pressure: 0.082mmHg at 25°C
• Refractive Index: 1.4755
• Storage Temp.: 2-8°C
• Solubility: Soluble in chloroform.
• PKA: 9.26±0.10(Predicted)
• CAS DataBase Reference: 4-Cyanopiperidine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Cyanopiperidine(4395-98-6)
• EPA Substance Registry System: 4-Cyanopiperidine(4395-98-6)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 20/21/22-36/37/38-41-22
• Safety Statements: 26-36/37/39-36-39
• RIDADR: 3276
• WGK Germany: 3
• HazardClass: 6.1
• PackingGroup: III
• Hazardous Substances Data: 4395-98-6(Hazardous Substances Data)

Usage

Description

4-Cyanopiperidine is an organic compound with the chemical formula C6H10N2. It is a heterocyclic amine that features a piperidine ring with a cyano group attached to the 4-position. 4-Cyanopiperidine is known for its potential applications in the pharmaceutical industry due to its unique chemical structure and reactivity.

Uses

Used in Pharmaceutical Industry:
4-Cyanopiperidine is used as an intermediate for the preparation of pharmaceutical substances such as antidepressants and anti-inflammatory drugs. Its presence in the synthesis process allows for the development of various medications that can help treat a range of conditions, including mood disorders and inflammation.
As a Precursor for Synthesis:
4-Cyanopiperidine serves as a precursor for the synthesis of piperidine derivatives. These derivatives are valuable in the creation of a variety of chemical compounds, including those with potential therapeutic applications. By using 4-Cyanopiperidine as a starting material, chemists can explore new pathways for the development of innovative pharmaceuticals and other useful compounds.

InChI:InChI=1/C6H10N2/c7-5-6-1-3-8-4-2-6/h6,8H,1-4H2

Upstream product

• 39546-32-2 4-carboxamidopiperidine 
• 77940-79-5 4-cyano-1-trifluoroacetylpiperidine 
• 498-94-2 isonipecotic acid 
• 91419-48-6 4-carbamoyl-piperidine-1-carboxylic acid tert-butyl ester 
• 91419-52-2 1-tert-butoxycarbonyl-4-cyanopiperidine 

Downstream Products

• 138522-66-4 1-<2-bis(4-fluorophenyl)methoxyethyl>-4-cyanopiperidine 
• 91419-52-2 1-tert-butoxycarbonyl-4-cyanopiperidine 
• 713147-47-8 1-cyclopropyl piperidine-4-carbonitrile 
• 713147-51-4 1-isopropylpiperidine-4-carbonitrile 
• 1117918-50-9 1-(2-chloro-6-(4-fluorophenyl)-pyrimidin-4-yl)-piperidine-4-carbonitrile 
• 62718-31-4 1-benzylpiperidine-4-carbonitrile 
• 1190979-80-6 1-(3-chloro-4-(1-(5-ethylpyrimidin-2-yl)piperidin-4-yloxy)benzyl)piperidine-4-carbonitrile 
• 1408865-76-8 C₁₂H₂₀N₂O 
• 1231921-26-8 1-(3-(4-(Pyridin-2-ylamino)phenoxy)pyrazin-2-yl)piperidine-4-carbonitrile 
• 1334674-10-0 2-cyclohexyloxy-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-1-(4-cyanopiperidine-1-carbonyl)-2,2-dimethylpropyl]amide 
• 1334675-85-2 2-cyclohexyloxy-5-(2-trimethylsilanylethoxymethyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-1-(4-cyanopiperidine-1-carbonyl)-2,2-dimethylpropyl]amide 
• 1351341-71-3 4-(5-{2-[(3R,4R)-3-tert-butoxycarbonylamino-4-(2,5-difluorophenyl)piperidin-1-yl]pyrimidin-5-yloxymethyl}-[1,2,4]oxadiazol-3-yl)piperidine-1-carboxylic acid isopropyl ester 
• 1351338-63-0 4-(5-{2-[(3R,4S)-3-amino-4-(2-fluorophenyl)pyrrolidin-1-yl]pyrimidin-5-yloxymethyl}-[1,2,4]oxadiazol-3-yl)piperidine-1-carboxylic acid isopropyl ester p-toluenesulfonate 
• 1351338-64-1 4-(5-{2-[(3R,4R)-3-amino-4-(2,5-difluorophenyl)piperidin-1-yl]pyrimidin-5-yloxymethyl}-[1,2,4]oxadiazol-3-yl)piperidine-1-carboxylic acid isopropyl ester hydrochloride 

Relevant articles and documents

Corresponding amine nitrile and method of manufacturing thereof

The invention relates to a manufacturing method of nitrile. Compared with the prior art, the manufacturing method has the characteristics of significantly reduced using amount of an ammonia source, low environmental pressure, low energy consumption, low production cost, high purity and yield of a nitrile product and the like, and nitrile with a more complex structure can be obtained. The invention also relates to a method for manufacturing corresponding amine from nitrile.

SULFONAMIDE DERIVATIVES AND METHODS OF USE THEREOF FOR IMPROVING THE PHARMACOKINETICS OF A DRUG

The present invention relates to Sulfonamide Derivatives of Formula (I): and pharmaceutically acceptable salts thereof, wherein A, W, X, R1, R2, R3, R4 and R5 are as defined herein. The present invention also relates to compositions comprising at least one Sulfonamide Derivative, and methods of using the Sulfonamide Derivatives for improving the pharmacokinetics of a drug.

SULFONAMIDE DERIVATIVES AND METHODS OF USE THEREOF FOR IMPROVING THE PHARMACOKINETICS OF A DRUG

The present invention relates to Sulfonamide Derivatives of Formula (I): and pharmaceutically acceptable salts thereof, wherein A, W, X, R1, R2, R3, R4 and R5 are as defined herein. The present invention also relates to compositions comprising at least one Sulfonamide Derivative, and methods of using the Sulfonamide Derivatives for improving the pharmacokinetics of a drug.