43189-12-4

Basic information

• Product Name: METHYL 2-AMINO-2-(4-HYDROXYPHENYL)ACETATE
• Synonyms: Methyl -amino-4-hydroxybenzene acetate;Methyl p-hydroxyphenylglycinate;Benzeneacetic acid, a-aMino-4-hydroxy-, Methyl ester;D(-)Para-HydroxyphenylglycineMethylEster;METHYL 2-AMINO-2-(4-HYDROXYPHENYL)ACETATE
• CAS NO: 43189-12-4
• Molecular Formula: C₉H₁₁NO₃
• Molecular Weight: 181.19
• Mol File: 43189-12-4.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 303.2±27.0 °C(Predicted)
• Appearance: /
• Density: 1.248±0.06 g/cm3(Predicted)
• PKA: 9.74±0.26(Predicted)
• CAS DataBase Reference: METHYL 2-AMINO-2-(4-HYDROXYPHENYL)ACETATE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL 2-AMINO-2-(4-HYDROXYPHENYL)ACETATE(43189-12-4)
• EPA Substance Registry System: METHYL 2-AMINO-2-(4-HYDROXYPHENYL)ACETATE(43189-12-4)

Safety Data

• Hazardous Substances Data: 43189-12-4(Hazardous Substances Data)

Upstream product

• 263895-06-3 (1-methoxycarbonyloxy-4-oxo-cyclohexa-2,5-dienyl)-acetic acid methyl ester 
• 67-56-1 methanol 
• 6324-01-2 p-hydroxyphenylglycine 
• 22818-40-2 D-4-hydroxyphenylglycine 
• 106-51-4 p-benzoquinone 

Downstream Products

• 1290605-96-7 methyl 2-(dimethylamino)-2-(4-hydroxyphenyl)acetate 
• 1454273-22-3 (R)-2-(4-(1-amino-2-(1-(2-fluoro-6-(trifluoromethyl)benzyl)-2,4-dioxo-1'-((5-(trifluoromethyl)furan-2-yl)methyl)-1H-spiro[furo[3,4-d]pyrimidine-5,4'-piperidin]-3(2H,4H,7H)-yl)ethyl)phenoxy)acetic acid 
• 26787-78-0 amoxicillin 
• 6324-01-2 p-hydroxyphenylglycine 
• 1262633-31-7 methyl 2-(3-(4-(5-(1,2-dithiolan-3-yl)pentanamido)phenyl)-2-(4-chlorobenzamido)-propanamido)-2-(4-hydroxyphenyl)acetate 
• 1262633-21-5 methyl 2-(3-(4-(5-(1,2-dithiolan-3-yl)pentanamido)phenyl)-2-(2-phenylacetamido)-propanamido)-2-(4-hydroxyphenyl)acetate 
• 1262633-11-3 methyl 2-(3-(4-(5-(1,2-dithiolan-3-yl)pentanamido)phenyl)-2-benzamidopropanamido)-2-(4-hydroxyphenyl)acetate 
• 1262633-03-3 methyl 2-(3-(4-(5-(1,2-dithiolan-3-yl)pentanamido)phenyl)-2-(2-cyclopentylacetamido)propanamido)-2-(4-hydroxyphenyl)acetate 
• 287407-57-2 (R)-methyl 2-(fluorenylmethoxycarbonyl)amino-2-(4-hydroxyphenyl)-acetic acid methyl ester 
• 143323-49-3 (R)-methyl 2-((tert-butoxycarbonyl)amino)-2-(4-hydroxyphenyl)acetate 
• 189266-11-3 (S)-{(R)-2-Acetylamino-3-[6-[5-(tert-butoxycarbonylamino-methyl)-2,3-dimethoxy-phenyl]-1-(toluene-4-sulfonyl)-1H-indol-3-yl]-propionylamino}-(3,5-dichloro-4-hydroxy-phenyl)-acetic acid methyl ester 

Relevant articles and documents

NEGATIVE ALLOSTERIC MODULATION OF GLUN3-CONTAINING N-METHYL-D-ASPARTATE RECEPTORS

Disclosed are negative allosteric modulators of GluN3-containing NMDA receptors. In general, these compounds are highly selective for GluN3 (such as GluN3A and/or GluN3B) over GluN1 and/or GluN2. They can function as non-competitive antagonists with activity that is independent of membrane potential, glycine concentration, and extracellular pH. Also disclosed are pharmaceutical formulations of the negative allosteric modulators. These compounds can be used to enhance synaptic function and/or treating a neurological condition or disorder. Exemplary neurological conditions or disorders include, but are not limited to, major mental disorders, conditions that involve basal ganglia or altered dopamine, substance abuse/addiction or predisposition to substance abuse/addiction, pain disorders, developmental delay or situations with impaired learning, memory, and/or cognition, acute neuronal or glial injuries, and circuit disorders.

Preparation method of amino-acid ester

The invention relates to a preparation method of amino-acid ester, and belongs to the field of synthesis of organic compounds. The preparation method of the amino-acid ester comprises the following steps: taking sulfur trioxide as a catalyst and a water-binding agent, catalyzing amino acid and alcohol to react so as to prepare sulfate of the amino-acid ester, then concentrating a reaction system to remove a reaction solvent and then adding water for dissolving, and neutralizing ammonia water to prepare the amino-acid ester. According to the technical scheme, the provided preparation method ofthe amino-acid ester has the advantages of mild reaction process, high yield, good purity, simplicity in operation and low cost. Concentrated condensate water of central mother liquor of the preparation method of the amino-acid ester can be directly subjected to biochemical treatment, solid by-products are high-purity ammonium sulfate, and can serve as chemical fertilizers, a reaction process is green and pollution-free, and thus, environmental protection is facilitated.

GONADOTROPIN RELEASING HORMONE RECEPTOR ANTAGONISTS, METHOD FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME

Disclosed are a gonadotropin releasing hormone receptor antagonist and a pharmaceutical composition including the same, which can be useful in preventing or treating a sex hormone-related disease such as endometriosis, amenorrhea, irregular menstruation, uterine myoma, uterine fibroids, polycystic ovarian disease, lupus erythematous, hypertrichosis, precocious puberty, short stature, acne, alopecia, gonadal steroid-dependent neoplasms, gonadotropin-producing pituitary adenoma, sleep apnea, irritable bowel syndrome, premenstrual syndrome, benign prostatic hyperplasia, contraception, and infertility, as well as Alzheimer disease.