43043-25-0

Basic information

• Product Name: 1-(2,3,4-trihydroxy-phenyl)-pentan-1-one
• Synonyms: 1-(2,3,4-trihydroxy-phenyl)-pentan-1-one
• CAS NO: 43043-25-0
• Molecular Weight: 210.23
• Mol File: 43043-25-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-(2,3,4-trihydroxy-phenyl)-pentan-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2,3,4-trihydroxy-phenyl)-pentan-1-one(43043-25-0)
• EPA Substance Registry System: 1-(2,3,4-trihydroxy-phenyl)-pentan-1-one(43043-25-0)

Safety Data

• Hazardous Substances Data: 43043-25-0(Hazardous Substances Data)

Upstream product

• 87-66-1 2-hydroxyresorcinol 
• 109-52-4 valeric acid 

Relevant articles and documents

Synthesis, antiproliferative, and c-Src kinase inhibitory activities of 4-oxo-4H-1-benzopyran derivatives

A new class of 4-oxo-4H-1-benzopyran derivatives were synthesized and their antiproliferative activity examined against a panel of three human cancer cell lines, that is, breast carcinoma (MDA-MB-468), ovarian adenocarcinoma (SK-OV-3), and colorectal adenocarcinoma (HT-29). Two compounds, that is, 3-hexyl-7,8-dihydroxy-4-oxo-4H-1-benzopyran and (E)-ethyl 3-(7-methoxy-4-oxo-4H-1-benzopyran-3-yl)acrylate were found to be potent against all three cancer cell lines studied at 50 μM concentration. Also, the inhibitory potency of the compounds was evaluated against active Src kinase. A few of these compounds exhibited modest Src kinase inhibitory activity (IC50 = 52-57 μM). Structure-activity relationship studies with respect to the nature and position of substituents on the lead compounds could be further exploited for the design and development of more potent antiproliferative agents and/or Src kinase inhibitors.