42302-17-0

Basic information

• Product Name: 3-(Dimethylamino)-1-propanethiol
• Synonyms: 3-(Dimethylamino)-1-propanethiol;1-Propanethiol, 3-(diMethylaMino)-;3-(dimethylamino)propane-1-thiol
• CAS NO: 42302-17-0
• Molecular Formula: C₅H₁₃NS
• Molecular Weight: 119.231
• Mol File: 42302-17-0.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 147.9 °C at 760 mmHg
• Flash Point: 43.2 °C
• Appearance: /
• Density: 0.900
• PKA: 8.83±0.10(Predicted)
• CAS DataBase Reference: 3-(Dimethylamino)-1-propanethiol(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(Dimethylamino)-1-propanethiol(42302-17-0)
• EPA Substance Registry System: 3-(Dimethylamino)-1-propanethiol(42302-17-0)

Safety Data

• Hazardous Substances Data: 42302-17-0(Hazardous Substances Data)

Usage

Description

3-(Dimethylamino)-1-propanethiol is a heterocyclic organic compound belonging to the class of alkaline amines. It is a clear, colorless liquid at room temperature with a strong and sharp smell. The molecular structure of this compound consists of a propyl group (a three-carbon alkyl group), a thiol (-SH) group, and a dimethylamino functional group (-NH(CH3)2). It exhibits high reactivity, readily reacting with acids and bases, making it suitable for various applications in chemical synthesis and pharmaceuticals. However, due to the presence of the thiol group, it can be hazardous, causing skin irritation and severe eye damage upon contact, and should be handled with appropriate protective measures.

Uses

Used in Chemical Synthesis:
3-(Dimethylamino)-1-propanethiol is used as a reagent in chemical synthesis for its high reactivity with acids and bases. Its unique molecular structure allows it to participate in various chemical reactions, making it a valuable component in the synthesis of complex organic compounds.
Used in Pharmaceutical Industry:
3-(Dimethylamino)-1-propanethiol is used as an intermediate in the production of pharmaceuticals. Its reactivity and molecular structure make it a key component in the synthesis of certain drugs, contributing to the development of new medications and therapies.
Used in Research and Development:
3-(Dimethylamino)-1-propanethiol is used as a research compound in the field of organic chemistry. Its properties and reactivity provide valuable insights into the behavior of similar compounds, aiding in the advancement of scientific knowledge and the discovery of new chemical reactions and processes.

Upstream product

• 66338-43-0 S-3-(dimethylamino)propyl ethanethioate 
• 3179-63-3 3-Dimethylamino-1-propanol 
• 23256-33-9 dimaprit dihydrochloride 
• 2155-94-4 N,N-dimethyl-2-propen-1-amine 
• 5407-04-5 3-(dimethylamino)propyl chloride hydrochloride 
• 17356-08-0 thiourea 

Downstream Products

• 166897-55-8 trans-[Ir(μ-S(CH2)3NMe2)(CO)(P(o-MeC6H4)3)]2 
• 166897-54-7 trans-[Ir(μ-S(CH2)3NMe2)(CO)(PCy3)]2 
• 166897-56-9 trans-[Ir(μ-S(CH2)3NMe2)(CO)(P(p-FC6H4)3)]2 
• 143215-12-7 Rh₂(S(CH₂)3N(CH₃)2)2(CO)2(P(CH₃C₆H₄)3)2 
• 88889-13-8 (R)-3-Benzyloxy-5-(3-dimethylamino-propylsulfanyl)-5,6,7,8-tetrahydro-quinoline-4-carbaldehyde 
• 101349-00-2 [(R)-3-Benzyloxy-5-(3-dimethylamino-propylsulfanyl)-5,6,7,8-tetrahydro-quinolin-4-yl]-methanol 
• 101349-01-3 [3-((R)-4-Aminomethyl-3-benzyloxy-5,6,7,8-tetrahydro-quinolin-5-ylsulfanyl)-propyl]-dimethyl-amine 
• 101349-09-1 (R)-3-Benzyloxy-5-(3-dimethylamino-propylsulfanyl)-5,6,7,8-tetrahydro-quinoline-4-carbaldehyde oxime 
• 57616-49-6 {3-[7-chloro-5-(2-chloro-phenyl)-3H-benzo[e][1,4]diazepin-2-ylsulfanyl]-propyl}-dimethyl-amine 
• 101348-98-5 (R)-3-Benzyloxy-5-(3-dimethylamino-propylsulfanyl)-5,6,7,8-tetrahydro-quinoline-4-carboxylic acid ethyl ester 
• 68276-30-2 11-Phenyl-6,11-dihydrodibenzothiepin-11-ol 

Relevant articles and documents

Behaviour of water-soluble dinuclear rhodium complexes in the hydroformylation reaction of oct-1-ene

The biphasic hydroformylation reaction of oct-1-ene, has been investigated by using the water-soluble dinuclear complex tBu)2(CO)2(TPPTS)2> as precursor.Addition of ethanol as a cosolvent dramatically improved the yields but the good regioselectivity in linear aldehyde observed for neat oct-1-ene-water systems (97percent) decreased to 83percent (for 22percent ethanol w/w).It is shown that the dinuclear framework cannot be maintained,that the mononuclear complex is formed, and that thiol and significant amounts of tBu)2(CO)4> move into the organic phase.This reaction from the dinuclear species requires the simultaneous presence of water and carbon monoxide.Introduction of the water-soluble thiol HS(CH2)3NMe2 in the bridging positions affords the complex Cl2 which can be kept in the aqueous phase but has a low level of catalytic activity. Key words: Rhodium; Hydroformylation; Alkenes; Biphasic catalysis

Detection of polycyclic aromatic hydrocarbons using quartz crystal microbalances

PAH are a complex class of hydrocarbons resulting from the incomplete combustion of organic substances such as fossil fuels, coal, fuel oil, gas, etc. A chemical coated piezoelectric sensor was developed to determine PAH (e.g., anthracene, naphthalene) in the liquid phase. The PAH derivative 9-anthracene carboxylic acid was used, which once bound to the alkane thiol functions as the recognition element. Binding of anthracene via π-π interaction was observed as a frequency shift in the quartz crystal microbalance with a detectability of the target analyte of 2 ppb and a response range of 0-50 ppb. Such a sensor could be used to identify key marker compounds and give an indication of total PAH flux in the environment. The mass sensitivity of the acoustic device could be improved by increasing the resonance frequency of the sensor because the sensor response to mass loading is proportional to the square of the operating frequency.

Modified ion exchange resins and use thereof

A modified strongly acidic ion exchange resin of a sulfonic acid type is disclosed. Modification is conducted by ionically binding a particular N,N-di-substituted mercaptoalkylamine to a strongly acidic ion exchange resin of a sulfonic acid type. The N,N-di-substituted mercaptoalkylamine is specifically represented by the following formulae: STR1 wherein R1 represents hydrogen or a C1-6 alkyl group, R2 and R3 independently represent a C1-10 alkyl group, a and b denote 0-3, respectively, a+b denotes 2 or 3, and m denotes 4 or 5. The modified ion exchange resin makes an improved catalyst in the preparation of a bisphenol by the condensation reaction of a phenol with a ketone.