423-60-9

Basic information

• Product Name: PERFLUOROOCTANESULPHONYL CHLORIDE
• Synonyms: HEPTADECAFLUORO-1-OCTANESULFONYL CHLORIDE;PERFLUORO-1-OCTANESULFONYL CHLORIDE;PERFLUOROOCTANESULPHONYL CHLORIDE;PERFLUOROOCTANESULFONYL CHLORIDE;Heptadecafluorooctanesulfonylchloride;1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-heptadecafluorooctane-1-sulfonyl chloride;1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-Heptadecafluorooctane-1-sulphonyl chloride;Perfluorooctane-1-sulphonyl chloride
• CAS NO: 423-60-9
• Molecular Formula: C₈ClF₁₇O₂S
• Molecular Weight: 518.58
• Mol File: 423-60-9.mol
• Article Data: 1

Chemical Properties

• Melting Point: 36 °C
• Boiling Point: 188.5 °C at 760 mmHg
• Flash Point: 67.8 °C
• Appearance: /
• Density: 1.813 g/cm³
• Vapor Pressure: 0.825mmHg at 25°C
• Refractive Index: 1.308
• Storage Temp.: Refrigerator, under inert atmosphere
• Solubility: Chloroform (Slightly), Ethyl Acetate (Slightly)
• Stability: Moisture Sensitive
• CAS DataBase Reference: PERFLUOROOCTANESULPHONYL CHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: PERFLUOROOCTANESULPHONYL CHLORIDE(423-60-9)
• EPA Substance Registry System: PERFLUOROOCTANESULPHONYL CHLORIDE(423-60-9)

Safety Data

• Hazard Codes: C,Xi
• Statements: 34
• Safety Statements: 26-36/37/39-45
• RIDADR: UN 3265 8/PG 2
• WGK Germany: 3
• F: 10-21
• Hazardous Substances Data: 423-60-9(Hazardous Substances Data)

Usage

Description

Perfluorooctanesulphonyl chloride, also known as Heptadecafluoro-1-octanesulfonyl chloride, is a fluorinated building block with the chemical formula C8F17SO2Cl. It is a fluoroakylating compound that is widely used in various chemical reactions and applications due to its unique properties.

Uses

Used in Chemical Synthesis:
Perfluorooctanesulphonyl chloride is used as a fluoroakylating agent for the phosphorus-induced fluoroalkylthiolation with fluoroalkylsulfonyl chlorides. This application is particularly important in the synthesis of complex organic molecules and pharmaceutical compounds that require fluorinated moieties for enhanced properties.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, perfluorooctanesulphonyl chloride is used as a key intermediate in the synthesis of various drugs and drug candidates. Its fluorinated nature can improve the pharmacokinetic and pharmacodynamic properties of the resulting compounds, leading to better efficacy and safety profiles.
Used in Material Science:
Perfluorooctanesulphonyl chloride is also utilized in the development of novel materials with unique properties, such as enhanced chemical stability, thermal resistance, and non-stick surfaces. These materials find applications in various industries, including aerospace, automotive, and electronics.
Used in Environmental Applications:
Due to its fluorinated structure, perfluorooctanesulphonyl chloride can be used in the development of environmentally friendly chemicals and processes. For example, it can be employed in the synthesis of compounds that have lower environmental impact or can be used in the treatment of contaminated water and soil.

InChI:InChI=1/C8ClF17O2S/c9-29(27,28)8(25,26)6(20,21)4(16,17)2(12,13)1(10,11)3(14,15)5(18,19)7(22,23)24

Upstream product

• 307-35-7 perfluorooctyl sulfofluorure 
• 423-39-2 1-iodo-2,2,3,3,4,4,5,5,5-nonafluorobutane 

Downstream Products

• 559-05-7 N-phenyl perfluorooctanesulfonamide 
• 307-35-7 perfluorooctyl sulfofluorure 
• 4151-50-2 N-ethyl-1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-heptadecafluorooctane-1-sulfonamide 
• 87988-61-2 N,N-diethyl-perfluorooctane-1-sulfonamide 
• 269746-32-9 (S)-2-[(2-Chloro-benzyl)-(heptadecafluorooctane-1-sulfonyl)-amino]-propionic acid 
• 627874-48-0 (S)-2-[(Heptadecafluorooctane-1-sulfonyl)-(4-nitro-benzyl)-amino]-propionic acid