41879-39-4 Usage
Description
O-(tert-Butyldimethylsilyl)hydroxylamine, also known as tert-butyldimethylsilyl-O-hydroxylamine, is an organic compound with the molecular formula (t-Bu)2Si(OH)NH2. It is characterized by its physical properties, including a melting point of 62-65°C and a boiling point of 87-90°C at 40 mmHg. O-(tert-Butyldimethylsilyl)hydroxylamine is known for its reactivity and is commonly utilized in various chemical processes and industries.
Uses
Used in Chemical Synthesis:
O-(tert-Butyldimethylsilyl)hydroxylamine is used as a reagent in the solid-supported synthesis of hydroxamic acids. It plays a crucial role in inducing the cleavage of these compounds, which are essential in various pharmaceutical and chemical applications.
Used as a Chemical Additive:
O-(tert-Butyldimethylsilyl)hydroxylamine also serves as a chemical additive, enhancing the properties of other substances in various industries. Its unique reactivity allows it to improve the performance of products in which it is incorporated.
Used as an Intermediate:
O-(tert-Butyldimethylsilyl)hydroxylamine is utilized as an intermediate in the synthesis of more complex organic compounds. Its ability to participate in various chemical reactions makes it a valuable component in the development of new materials and products.
Preparation
the reagents are most conveniently prepared
by treatment of hydroxylamine hydrochloride with
ethylenediamine in dichloromethane, followed by the appropriate
chlorosilane.A two-step procedure using ammonia in
place of ethylenediamine has also been reported.
Check Digit Verification of cas no
The CAS Registry Mumber 41879-39-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 4,1,8,7 and 9 respectively; the second part has 2 digits, 3 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 41879-39:
(7*4)+(6*1)+(5*8)+(4*7)+(3*9)+(2*3)+(1*9)=144
144 % 10 = 4
So 41879-39-4 is a valid CAS Registry Number.
InChI:InChI=1/C6H17NOSi/c1-6(2,3)9(4,5)8-7/h7H2,1-5H3
41879-39-4Relevant articles and documents
PENICILLIN-BINDING PROTEIN INHIBITORS
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Paragraph 00295, (2018/12/13)
Described herein are certain boron-containing compounds, compositions, preparations and their use as modulators of the transpeptidase function of bacterial penicillin-binding proteins and as antibacterial agents. In some embodiments, the compounds described herein inhibit penicillin-binding proteins. In certain embodiments, the compounds described herein are useful in the treatment of bacterial infections.
O-TBS-N-tosylhydroxylamine: A reagent for facile conversion of alcohols to oximes
Kitahara, Katsushi,Toma, Tatsuya,Shimokawa, Jun,Fukuyama, Tohru
supporting information; experimental part, p. 2259 - 2261 (2009/05/26)
(Chemical Equation Presented) A variety of oximes were synthesized from the corresponding alcohols, alkyl halides, or alkyl sulfonates without using external oxidants. With this simple two-step procedure involving substitution with readily available TsNHOTBS and subsequent treatment with CsF, a range of oximes were prepared including the ones hardly preparable with conventional procedures.
New C-3′ hydroxamate-substituted and more lipophilic cyclic hydroxamate cephalosporin derivatives as a potential new generation of selective antimicrobial agents
Miller, Marvin J.,Zhao, Gaiying,Vakulenko, Sergei,Franzblau, Scott,Moellmann, Ute
, p. 4178 - 4185 (2008/09/20)
Syntheses of a series of new C-3′ hydroxamate-substituted cephalosporin derivatives with potent antibacterial and media-dependent anti-TB activity are described. The Royal Society of Chemistry 2006.
