41687-30-3Relevant articles and documents
Preparation method of dye intermediate 3-(beta-hydroxyethyl sulfonyl) aniline
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, (2020/04/17)
The invention discloses a preparation method of dye intermediate 3-(beta-hydroxyethyl sulfonyl) aniline. The preparation method comprises the following steps: carrying out chlorosulfonation reaction on nitrobenzene and chlorosulfonic acid to obtain m-nitrobenzenesulfonyl chloride; reducing m-nitrobenzenesulfonyl chloride by using sodium pyrosulfite, and regulating the pH value of a reaction solution to 7.4-7.7 in the reaction process; adding sodium chloride after the reaction is finished, and salting out to obtain a reduction product; wherein the molar ratio of sodium pyrosulfite to m-nitrobenzenesulfonyl chloride to sodium chloride is (0.68-0.685): 1: (0.54-0.58); adding ethylene oxide into the reduction product, controlling the PH value to be 7-7.5, and reacting to obtain a condensationproduct; adopting stannous chloride and a Pd/C catalyst for reducing the condensation product to obtain 3-(beta-hydroxyethyl sulfonyl) aniline, wherein the molar ratio of the condensation product to the Pd/C catalyst is (0.45-0.46): 1: 0.0012. The preparation method provided by the invention can effectively inhibit the generation of byproducts in each process link, not only can improve the productquality, but also reduce environmental pollutants, and has a green and environment-friendly effect.
Preparation method of dye intermediate 3-(beta-hydroxyethyl sulfonyl)-nitrobenzene
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, (2020/05/14)
The invention discloses a preparation method of a dye intermediate 3-(beta-hydroxyethyl sulfonyl)-nitrobenzene. The preparation method comprises the following steps: S1, carrying out chlorosulfonationreaction on nitrobenzene and chlorosulfonic acid to obtain m-nitrobenzenesulfonyl chloride; S2, reducing the m-nitrobenzenesulfonyl chloride by using sodium pyrosulfite, and adjusting the pH value ofthe reaction solution to 7.4-7.7 in the reaction process; adding sodium chloride after the reaction is finished, and salting out to obtain a reduction product, wherein the molar ratio of the sodium pyrosulfite to the m-nitrobenzenesulfonyl chloride to the sodium chloride is (0.68-0.685) : 1 : (0.54-0.58); and S3, adding ethylene oxide and sodium phosphate into the reduction product, controlling the pH value to be 7-7.5, and reacting to obtain 3-(beta-hydroxyethyl sulfonyl)-nitrobenzene, wherein the molar ratio of the reduction product to the ethylene oxide to the sodium phosphate is 1: (0.52-0.63): 0.00.12. The preparatio method effectively inhibits the generation of byproducts in each process link, not only improves the product quality, but also reduces environmental pollutants and has agreen and environment-friendly effect.
Pteridinone derivatives as PI3-kinases inhibitors
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Page/Page column 17, (2008/12/07)
New compounds of formula 1 are provided which by virtue of their pharmaceutical activity as PI3-kinase modulators may be used in the therapeutic field for the treatment of inflammatory or allergic diseases. Examples of these include inflammatory and allergic respiratory complaints, inflammatory diseases of the gastro-intestinal tract and motor apparatus, inflammatory and allergic skin diseases, inflammatory eye diseases, diseases of the nasal mucosa, inflammatory or allergic conditions involving autoimmune reactions or inflammations of the kidney.