415932-72-8

Basic information

• Product Name: Morpholine, 4-[(2-chlorophenyl)methyl]-
• CAS NO: 415932-72-8
• Molecular Formula: C11H14ClNO
• Molecular Weight: 211.691
• Mol File: 415932-72-8.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: Morpholine, 4-[(2-chlorophenyl)methyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Morpholine, 4-[(2-chlorophenyl)methyl]-(415932-72-8)
• EPA Substance Registry System: Morpholine, 4-[(2-chlorophenyl)methyl]-(415932-72-8)

Safety Data

• Hazardous Substances Data: 415932-72-8(Hazardous Substances Data)

Upstream product

• 110-91-8 morpholine 
• 611-19-8 1-chloro-2-(chloromethyl)benzene 
• 611-17-6 1-bromomethyl-2-chlorobenzene 
• 4394-85-8 4-morpholinecarboxaldehyde 
• 345-34-6 1-chloro-2-(fluoromethyl)benzene 

Relevant articles and documents

Thiourea-Catalyzed C?F Bond Activation: Amination of Benzylic Fluorides

We describe the first thiourea-catalyzed C?F bond activation. The use of a thiourea catalyst and Ti(OiPr)4 as a fluoride scavenger allows the amination of benzylic fluorides to proceed in moderate to excellent yields. Preliminary results with S- and O-based nucleophiles are also presented. DFT calculations reveal the importance of hydrogen bonds between the catalyst and the fluorine atom of the substrate to lower the activation energy during the transition state.

PREPARATION OF HALOGENATED DI-SUBSTITUTED BENZYLAMINES, PARTICULARLY HALOGENATED DIALKYLBENZYLAMINES

The present invention relates to a novel process for preparing halogenated di-substituted benzylamines, particularly halogenated dialkylbenzylamines.

Highly efficient amination in neat water of benzyl chlorides with dialkylformamides catalysed by N-heterocyclic carbene-palladium(II)-1- methylimidazole complex

Dialkylformamides are excellent N-sources in the amination of benzyl chlorides when catalysed by a NHC-Pd(II)-Im complex. In the presence of NaOH and the catalyst, variously substituted benzyl chlorides and five different dialkylformamides reacted smoothly to afford the corresponding N,N-dialkyl-benzylamines in good to almost quantitative yields in eco-friendly solvent water at 50 °C within 3 h.