4133-35-1

Basic information

• Product Name: 6-Bromo-2-tetralone
• Synonyms: 6B2T;6-BROMO-2-TETRALONE;6-BROMO-3,4-DIHYDRO-2(1H)-NAPHTHALENONE;6-BROMO-3,4-DIHYDRO-1H-NAPHTHALEN-2-ONE;6-Bromo-3,4-dihydronaphthalen-2(1H)-one;6-BROMO-2-TETRALONE 98%;6-Bromo-2-tetralone, 98 %;6-bromo-2-teralone
• CAS NO: 4133-35-1
• Molecular Formula: C₁₀H₉BrO
• Molecular Weight: 225.08
• EINECS: 207-216-6
• Product Categories: pharmacetical;CHIRAL CHEMICALS
• Mol File: 4133-35-1.mol
• Article Data: 19

Chemical Properties

• Melting Point: 70-76 °C
• Boiling Point: 319.2 °C at 760 mmHg
• Flash Point: 108.7 °C
• Appearance: Pale yellow to brown/Crystalline Powder
• Density: 1.3991 (rough estimate)
• Vapor Pressure: 0.000344mmHg at 25°C
• Refractive Index: 1.5560 (estimate)
• Storage Temp.: 0-6°C
• CAS DataBase Reference: 6-Bromo-2-tetralone(CAS DataBase Reference)
• NIST Chemistry Reference: 6-Bromo-2-tetralone(4133-35-1)
• EPA Substance Registry System: 6-Bromo-2-tetralone(4133-35-1)

Safety Data

• Hazard Codes: Xi
• Safety Statements: 24/25
• WGK Germany: 3
• Hazardous Substances Data: 4133-35-1(Hazardous Substances Data)

Usage

Chemical Properties

pale yellow to brown crystalline powder

InChI:InChI=1/C10H9BrO/c11-9-3-1-8-6-10(12)4-2-7(8)5-9/h1,3,5H,2,4,6H2

Upstream product

• 79-37-8 oxalyl dichloride 
• 74-85-1 ethene 
• 1878-68-8 2-(4-bromophenyl)-acetic acid 
• 37859-24-8 2-(4-bromophenyl)acetyl chloride 

Downstream Products

• 659736-46-6 3',4'-dihydro-6'-bromo-spiro[imidazolidine-4,2'(1'H)-naphthalene]-2,5-dione 
• 912935-60-5 4-(6-dipropylamino-5,6,7,8-tetrahydro-naphthalen-2-ylmethylsulfanyl)-phenol 
• 167355-41-1 6-bromo-1,2,3,4-tetrahydronaphthalen-2-amine 
• 740842-85-7 7-bromo-1,2,4,5-tetrahydro-3H-benzo[c]azepin-3-one 
• 740842-84-6 7-bromo-1,3,4,5-tetrahydro-2H-benzo[d]azepin-2-one 
• 912953-53-8 6-[4-(trifluoromethyl)phenyl]-3,4-dihydro-2(1H)-naphthalenone 
• 113075-66-4 1-(6-bromo-3,4-dihydro-2-naphthyl)pyrrolidine 
• 418772-22-2 1-(1-(RS)-benzyl-6-bromo-3,4-dihydro-1H-naphthalen-2-ylidene)-pyrrolidinium bromide 
• 863925-41-1 N-benzyl-6-bromo-1,2,3,4-tetrahydronaphthalen-2-amine 
• 740842-87-9 7-bromo-2,3,4,5-tetrahydro-1H-benzo[c]azepine 
• 740842-86-8 7-bromo-2,3,4,5-tetrahydro-1H-benzo[d]azepine 
• 740842-89-1 tert-butyl 7-bromo-2,3,4,5-tetrahydro-2H-benzo[c]azepine-2-carboxylate 
• 740842-88-0 tert-butyl 7-bromo-1,2,4,5-tetrahydro-3H-benzo[d]azepine-3-carboxylate 
• 1414795-08-6 2-(6-{4-[(phenylcarbamoyl)amino]phenyl}-1,2,3,4-tetrahydronaphthalen-2-yl)acetic acid 

Relevant articles and documents

Discovery and Development of Metal-Catalyzed Coupling Reactions in the Synthesis of Dasabuvir, an HCV-Polymerase Inhibitor

Dasabuvir (1) is an HCV polymerase inhibitor which has been developed as a part of a three-component direct-acting antiviral combination therapy. During the course of the development of the synthetic route, two novel coupling reactions were developed. First, the copper-catalyzed coupling of uracil with aryl iodides, employing picolinamide 16 as the ligand, was discovered. Later, the palladium-catalyzed sulfonamidation of aryl nonaflate 33 was developed, promoted by electron-rich palladium complexes, including the novel phosphine ligand, VincePhos (50). This made possible a convergent, highly efficient synthesis of dasabuvir that significantly reduced the mutagenic impurity burden of the process.

1-(DIHYDRONAPHTHALENYL)PYRIDONES AS MELANIN-CONCENTRATING HORMONE RECEPTOR 1 ANTAGONISTS

This invention relates to novel 1-(dihydronaphthalenyl)pyridones which are antagonists of the melanin-concentrating hormone receptor 1 (MCHR1), to pharmaceutical compositions containing them, to processes for their preparation, and to their use in therapy

Tricyclic Compound, Compositions, and Methods

The present invention is directed to compounds of Formula I: or salt thereof, which are modulators of the glucocorticoid receptor. The compounds and salts of the invention are useful in the treatment of conditions mediated by glucocorticoid receptor activity.