41248-20-8

Basic information

• Product Name: Bicyclo[2.2.1]heptane-2-carboxylic acid, 2-hydroxy-
• Synonyms: (+-)-2-hydroxy-norbornane-2endo-carboxylic acid;2-exo-Hydroxy-bicyclo<2.2.1>heptan-2-carbonsaeure;Bicyclo[2.2.1]heptane-2-carboxylic acid,2-hydroxy;Bicyclo-<1.2.2>-heptanol-(2exo)-carbonsaeure-(2endo);(+-)-2-Hydroxy-norbornan-2endo-carbonsaeure;exo-2-Hydroxy-norbornan-endo-2-carbonsaeure
• CAS NO: 41248-20-8
• Molecular Formula: C8H12O3
• Molecular Weight: 156.181
• Mol File: 41248-20-8.mol
• Article Data: 5

Chemical Properties

• Melting Point: 90 °C
• Boiling Point: 323.8±25.0 °C(Predicted)
• Density: 1.383±0.06 g/cm3(Predicted)
• CAS DataBase Reference: Bicyclo[2.2.1]heptane-2-carboxylic acid, 2-hydroxy-(CAS DataBase Reference)
• NIST Chemistry Reference: Bicyclo[2.2.1]heptane-2-carboxylic acid, 2-hydroxy-(41248-20-8)
• EPA Substance Registry System: Bicyclo[2.2.1]heptane-2-carboxylic acid, 2-hydroxy-(41248-20-8)

Safety Data

• Hazardous Substances Data: 41248-20-8(Hazardous Substances Data)

Upstream product

• 934-28-1 norbornane-2-carboxylic acid 
• 75670-50-7 2-Hydroxy-bicyclo<2.2.1>bept-5-en-2-carbonsaeure 
• 101251-10-9 (+/-)-2-bromo-norbornane-2endo-carbonyl chloride 
• 2534-90-9 exo-2-bromobicyclo<2.2.1>heptane-1-carboxylic acid 
• 2534-71-6 (+/-)-2-bromo-norbornane-2endo-carboxylic acid 
• 80452-18-2 6-endo-tosyloxynorbornane-2-carboxylic acid sodium salt 
• 80452-18-2 6-exo-tosyloxynorbornane-2-carboxylic acid sodium salt 
• 2566-59-8 (+)-(1S,2R,4R)-bicyclo<2.2.1>heptane-2-carboxylic acid 
• 2534-71-6 (+/-)-2-bromo-norbornane-2exo-carboxylic acid 
• 153923-33-2 2-endo-hydroxybicyclo[2.2.1]hept-5-ene-2-exo-carboxylic acid 
• 99768-20-4 exo-2-Bromo-bicyclo<2.2.1>hept-5-ene 2-carboxylic acid 

Downstream Products

• 97850-71-0 Tricyclo[2.2.1.0^2,6]heptane-1-carboxylic acid dimethylamide 
• 497-38-1 (1S,4R)-bicyclo[2.2.1]heptan-2-one 
• 497-38-1 Norbornan-2-on 

Relevant articles and documents

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Method for producing optically active 3-substituted-2-norbornanones and their intermediates

The present invention provides a method for producing optically active 3-substituted-2-norbornanones which are useful as starting materials for several kinds of physiologically active materials, and to their intermediates, optically active 2-hydroxy-2-norbornanecarboxylic acid and to a method for producing these intermediates.

Carbon Participation in the Solvolysis of 6-exo-substituted 2-exo- and 2-endo-Norbornyl p-Toluenesulfonates. Norbornanes Part 5

The solvolysis rates and products of the 6-exo-substituted 2-exo- 1a-1u, and 2-endo-norbornyl p-toluenesulfonates 2a-2u, have been determined.In general, the rate constants for 1 and 2 (log k) correlate well with the inductive constants ?qI of the substituents at C(6); however, their sensitivity to ?qI is much larger in the 2-exo-series 1 than in the 2-endo-series 2.This differential transmission of polar effects is the cause of decreasing 2-exo/2-endo rate ratios from 2388 for R=t-C4H9 to 0.37 for R=Br, i.e., with increasing electron attraction by the substituent.The high sensitivity of the rate constants for the 2-exo-p-toluenesulfonates 1 to ?qI indicates an unusually strong inductive interaction between C(6) and the incipient cationic center at C(2).This interaction is ascribed to the participation of the pentacoordinate C(6)-atom, i.e. to 1,3-bridging, a consequence of steric hindrance of nucleophilic solvent participation in norbornanes.Donor substituents enhanche 1,3-bridging, lead to faster reactions and to the formation of 2-exo substitution products.Conversely, acceptor substituents reduce 1,3-bridging, decrease rates and facilitate the formation of 2-endo substitution products.Graded 1,3-bridging is discussed in the light of Winstein's nonclassical ion concept.