40812-76-8

Basic information

• Product Name: Benzoyl chloride, 3-hydroxy- (9CI)
• Synonyms: Benzoyl chloride, 3-hydroxy- (9CI);Benzoyl chloride, 3-hydroxy-
• CAS NO: 40812-76-8
• Molecular Formula: C₇H₅ClO₂
• Molecular Weight: 156.5664
• Product Categories: ACIDHALIDE
• Mol File: 40812-76-8.mol
• Article Data: 23

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Benzoyl chloride, 3-hydroxy- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoyl chloride, 3-hydroxy- (9CI)(40812-76-8)
• EPA Substance Registry System: Benzoyl chloride, 3-hydroxy- (9CI)(40812-76-8)

Safety Data

• Hazardous Substances Data: 40812-76-8(Hazardous Substances Data)

Usage

Uses

3-Hydroxybenzoyl Chloride is a useful reagent in preparation and the biological activities of substituted 1,3,4-oxadiazole derivatives.

Upstream product

• 99-06-9 3-Carboxyphenol 
• 1700-37-4 3-Benzyloxybenzaldehyde 
• 100-83-4 meta-hydroxybenzaldehyde 
• 75-44-5 phosgene 

Downstream Products

• 618-49-5 3-hydroxybenzamide 
• 13161-32-5 4-hydroxy-3H-isobenzofuran-1-one 
• 4792-33-0 4-methoxyphthalide 
• 62924-93-0 N,N-diethyl-3-methoxybenzamide 
• 70946-15-5 N,N-diethyl 2-formyl-3-methoxybenzamide 
• 1426060-08-3 C₁₅H₁₂ClNO₄ 
• 1426130-86-0 C₁₇H₁₆BrNO₄ 
• 1426059-01-9 C₁₉H₂₀BrNO₄ 
• 926262-01-3 C₁₄H₁₀ClNO₄ 
• 697235-58-8 N-(3-hydroxybenzoyl)anthranilic acid 
• 926251-82-3 C₁₄H₁₀N₂O₆ 
• 668264-65-1 5-bromo-2-[(3-hydroxybenzoyl)amino]benzoic acid 
• 1400173-74-1 C₁₈H₁₈BrNO₄ 
• 1409481-25-9 C₁₄H₁₂N₂O₄ 

Relevant articles and documents

Hydroxybenzoyl Chlorides in the Synthesis of Conjugates with Biologically Active Dipeptides

Abstract: Conjugates of hydroxy- and acetoxybenzoic acids with dipeptides based on 4-aminobutanoic acid and glycine were synthesized through hydroxy(acetoxy)benzoyl chlorides and 4-[hydroxy(acetoxy)benzoyl-amino]butanoyl chlorides as intermediate products. Acyl chlorides were prepared by treatment of the corre-sponding acids with oxalyl chloride in the presence of dimethylformamide at a ratio of 1:1.1:0.07 in boiling benzene. The target N-[hydroxy(acetoxy)benzoyl] derivatives of dipeptides were obtained with high yields, and no further purification of the products was necessary. The synthesized compounds were evaluated as potential neuroprotective agents.

Discovery of novel phenoxybenzamide analogues as Raf/HDAC dual inhibitors

Histone deacetylase (HDAC)inhibitors as an important epigenetic therapeutic strategy affect signaling networks and act synergistically with kinase inhibitors for the treatment of cancer. Herein we presented a series of novel phenoxybenzamide analogues with inhibition of Raf and HDAC. Among them, compound 10e showed potent antiproliferative activities against Hepg2 and MDA-MB-468 in cellular assays. This work may lay the foundation for developing novel dual Raf/HDAC inhibitors as potential anticancer therapeutics.

A synthesis method of benzaldehyde (by machine translation)

The invention provides a synthesis method of benzaldehyde, the method comprises: (1) the hydroxy benzoic acid as the raw material, N, N - dimethyl formamide or N, N - dimethyl acetamide as catalyst, in the presence of acyl, to carry out the following formula 1 shown between the acyl chloride reaction in order to produce hydroxy benzoyl chloride; and (2) in the presence of hydrogen, in the presence of a catalyst, in the step (1) the resulting hydroxy benzoyl chloride of the following carried out 2 is shown between the hydrogenation reduction reaction of benzaldehyde. According to the method of the present invention mild condition, few steps, synthetic high yield, production process has no waste water, compared with the traditional method, the advantages of environmental protection, energy-saving high-efficiency, small equipment footprint, the product quality is in quality. [Formula 1] [Formula 2] (by machine translation)